Incorporation of raloxifene-impregnated allograft around orthopedic titanium implants impairs early fixation but improves new bone formation: A 4-week study in 12 dogs

Lars L Hermansen, Mette Sørensen, Jeppe Barckman, Joan E Bechtold, Kjeld Søballe, Jørgen Baas

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

BACKGROUND: The anti-osteoporotic drug raloxifene reduces the risk of vertebral fractures by increasing bone mass density. We investigated whether raloxifene offers any benefits in augmenting early fixation of orthopedic implants in the setting of impaction bone grafting.

METHODS: 24 non-weight-bearing grafted gap implants were inserted bilaterally into the tibia of 12 dogs. The 2.5-mm peri-implant gap was filled with either raloxifene-impregnated or untreated bone allograft. Implants were harvested after 28 days. Implant fixation was assessed by mechanical testing and histomorphometric evaluation.

RESULTS: Raloxifene-treated allograft reduced early implant fixation compared to untreated allograft, as measured by inferior maximum shear strength (p < 0.001) and apparent shear stiffness (p = 0.001). We found that the raloxifene group had more newly formed bone in the gap around the implant (p = 0.02), but also less allograft (p = 0.03).

INTERPRETATION: The accelerated allograft resorption in the raloxifene group explained the impaired early fixation, despite its stimulation of new bone formation. Our results with local and possible high-dose treatment are not consistent with current theory regarding the mechanism of how systemic raloxifene administration counteracts the decrease in BMD in postmenopausal women. Instead of being solely anti-resorptive as generally held, our results indicate a possible anabolic side of raloxifene.

OriginalsprogEngelsk
TidsskriftActa Orthopaedica (Print Edition)
Vol/bind86
Udgave nummer1
Sider (fra-til)127-33
ISSN1745-3674
DOI
StatusUdgivet - feb. 2015
Udgivet eksterntJa

Fingeraftryk Dyk ned i forskningsemnerne om 'Incorporation of raloxifene-impregnated allograft around orthopedic titanium implants impairs early fixation but improves new bone formation: A 4-week study in 12 dogs'. Sammen danner de et unikt fingeraftryk.

  • Citationsformater