Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women

Nils Koch-Henriksen*, Lau Caspar Thygesen, Egon Stenager, Bjarne Laursen, Melinda Magyari

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective: To describe the pattern of development of incidence of multiple sclerosis (MS) over 60 years in Denmark with age-period-cohort analyses and seasonality of birth. Methods: Data on virtually all patients with onset of MS have since 1950 been prospectively recorded and kept in the Danish Multiple Sclerosis Registry with multiple sources of notification. Annualized incidence rates per 100,000 were directly standardized to the European Standard Population. Results: We have registered 19,536 cases with clinical onset of confirmed MS in Denmark from 1950 to 2009. From the 1950-1959 to the 2000-2009 onset period, incidence more than doubled in women, with an increase from 5.91 (95% confidence interval [CI]: 5.60-6.24) to 12.33 (95% CI: 11.91-12.75) per 100,000 per year compared with a modest 24% increase in men from 4.52 (95% CI: 4.24-4.81) to 6.08 (95% CI: 5.79-6.38). With age at onset of 50 years and older, incidence increased with a factor 4.30 in women and 2.72 in men. The female/male sex ratio increased over time and with year of birth. Age-period-cohort analysis revealed a significant birth cohort effect in addition to the age and period effect. We found no statistically significant seasonality of births. Conclusion: The incidence of MS has doubled in women, most pronounced with late onset, and has only modestly increased in men. Lifestyle changes in the female population that could include fewer childbirths, increased occurrence of obesity, and increased cigarette consumption may have a role.

OriginalsprogEngelsk
TidsskriftNeurology
Vol/bind90
Udgave nummer22
Sider (fra-til)e1954-e1963
ISSN0028-3878
DOI
StatusUdgivet - 29. maj 2018

Fingeraftryk

Denmark
Confidence Intervals
Incidence
Cohort Studies
Cohort Effect
Sex Ratio
Age of Onset
Population
Registries

Citer dette

@article{4981dd25eefc46f5a4460b1c057d432e,
title = "Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women",
abstract = "Objective: To describe the pattern of development of incidence of multiple sclerosis (MS) over 60 years in Denmark with age-period-cohort analyses and seasonality of birth. Methods: Data on virtually all patients with onset of MS have since 1950 been prospectively recorded and kept in the Danish Multiple Sclerosis Registry with multiple sources of notification. Annualized incidence rates per 100,000 were directly standardized to the European Standard Population. Results: We have registered 19,536 cases with clinical onset of confirmed MS in Denmark from 1950 to 2009. From the 1950-1959 to the 2000-2009 onset period, incidence more than doubled in women, with an increase from 5.91 (95{\%} confidence interval [CI]: 5.60-6.24) to 12.33 (95{\%} CI: 11.91-12.75) per 100,000 per year compared with a modest 24{\%} increase in men from 4.52 (95{\%} CI: 4.24-4.81) to 6.08 (95{\%} CI: 5.79-6.38). With age at onset of 50 years and older, incidence increased with a factor 4.30 in women and 2.72 in men. The female/male sex ratio increased over time and with year of birth. Age-period-cohort analysis revealed a significant birth cohort effect in addition to the age and period effect. We found no statistically significant seasonality of births. Conclusion: The incidence of MS has doubled in women, most pronounced with late onset, and has only modestly increased in men. Lifestyle changes in the female population that could include fewer childbirths, increased occurrence of obesity, and increased cigarette consumption may have a role.",
author = "Nils Koch-Henriksen and Thygesen, {Lau Caspar} and Egon Stenager and Bjarne Laursen and Melinda Magyari",
year = "2018",
month = "5",
day = "29",
doi = "10.1212/WNL.0000000000005612",
language = "English",
volume = "90",
pages = "e1954--e1963",
journal = "Neurology",
issn = "0028-3878",
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Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women. / Koch-Henriksen, Nils; Thygesen, Lau Caspar; Stenager, Egon; Laursen, Bjarne; Magyari, Melinda.

I: Neurology, Bind 90, Nr. 22, 29.05.2018, s. e1954-e1963.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women

AU - Koch-Henriksen, Nils

AU - Thygesen, Lau Caspar

AU - Stenager, Egon

AU - Laursen, Bjarne

AU - Magyari, Melinda

PY - 2018/5/29

Y1 - 2018/5/29

N2 - Objective: To describe the pattern of development of incidence of multiple sclerosis (MS) over 60 years in Denmark with age-period-cohort analyses and seasonality of birth. Methods: Data on virtually all patients with onset of MS have since 1950 been prospectively recorded and kept in the Danish Multiple Sclerosis Registry with multiple sources of notification. Annualized incidence rates per 100,000 were directly standardized to the European Standard Population. Results: We have registered 19,536 cases with clinical onset of confirmed MS in Denmark from 1950 to 2009. From the 1950-1959 to the 2000-2009 onset period, incidence more than doubled in women, with an increase from 5.91 (95% confidence interval [CI]: 5.60-6.24) to 12.33 (95% CI: 11.91-12.75) per 100,000 per year compared with a modest 24% increase in men from 4.52 (95% CI: 4.24-4.81) to 6.08 (95% CI: 5.79-6.38). With age at onset of 50 years and older, incidence increased with a factor 4.30 in women and 2.72 in men. The female/male sex ratio increased over time and with year of birth. Age-period-cohort analysis revealed a significant birth cohort effect in addition to the age and period effect. We found no statistically significant seasonality of births. Conclusion: The incidence of MS has doubled in women, most pronounced with late onset, and has only modestly increased in men. Lifestyle changes in the female population that could include fewer childbirths, increased occurrence of obesity, and increased cigarette consumption may have a role.

AB - Objective: To describe the pattern of development of incidence of multiple sclerosis (MS) over 60 years in Denmark with age-period-cohort analyses and seasonality of birth. Methods: Data on virtually all patients with onset of MS have since 1950 been prospectively recorded and kept in the Danish Multiple Sclerosis Registry with multiple sources of notification. Annualized incidence rates per 100,000 were directly standardized to the European Standard Population. Results: We have registered 19,536 cases with clinical onset of confirmed MS in Denmark from 1950 to 2009. From the 1950-1959 to the 2000-2009 onset period, incidence more than doubled in women, with an increase from 5.91 (95% confidence interval [CI]: 5.60-6.24) to 12.33 (95% CI: 11.91-12.75) per 100,000 per year compared with a modest 24% increase in men from 4.52 (95% CI: 4.24-4.81) to 6.08 (95% CI: 5.79-6.38). With age at onset of 50 years and older, incidence increased with a factor 4.30 in women and 2.72 in men. The female/male sex ratio increased over time and with year of birth. Age-period-cohort analysis revealed a significant birth cohort effect in addition to the age and period effect. We found no statistically significant seasonality of births. Conclusion: The incidence of MS has doubled in women, most pronounced with late onset, and has only modestly increased in men. Lifestyle changes in the female population that could include fewer childbirths, increased occurrence of obesity, and increased cigarette consumption may have a role.

UR - http://www.scopus.com/inward/record.url?scp=85052750229&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000005612

DO - 10.1212/WNL.0000000000005612

M3 - Journal article

C2 - 29720546

AN - SCOPUS:85052750229

VL - 90

SP - e1954-e1963

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 22

ER -