Incidence of benign prostate hypertrophy in Danish men with and without HIV infection

Magnus Glindvad Ahlström, Gitte Kronborg, Carsten S Larsen, Court Pedersen, Gitte Pedersen, Jan Gerstoft, Niels Obel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Information on risk of benign prostate hypertrophy (BPH) in HIV-infected men is sparse. We aimed to estimate the incidence of being diagnosed with BPH among HIV-infected men compared with an age and sex-matched comparison cohort from the background population. To exclude that family-associated risk factors influence risk of BPH diagnoses in families of HIV-infected individuals, we estimated risk of BPH in fathers of HIV-infected men and fathers of the comparison cohort.

METHODS: In a nationwide, population-based, matched cohort study, we calculated incidence rates and used Poisson regression models to calculate incidence rate ratios (IRRs) of being diagnosed with BPH, defined as the earliest of date of the second redeemed prescription of a drug used to treat BPH, the first registration of a BPH diagnosis in the Danish National Hospital Registry (DNHR) or the first registration of a surgical procedure for BPH in DNHR.

RESULTS: We identified 4633 HIV-infected men, 46 330 comparison cohort individuals, 1585 fathers of HIV-infected men and 20 449 fathers of the comparison cohort. Incidence rate of being diagnosed with BPH was 37.0 [95% confidence interval (95% CI) 31.5-43.1] per 10 000 person-years of follow-up among HIV-infected men and was not increased compared with the comparison cohort (IRR 1.04, 95% CI 0.88-1.22). Risk was not increased for fathers of HIV-infected men vs. fathers of the comparison cohort (IRR 0.99, 95% CI 0.87-1.12). Stratified analyses did not change the above results markedly.

CONCLUSION: HIV-infected individuals do not have an increased risk of being diagnosed with BPH.

OriginalsprogEngelsk
TidsskriftAIDS
Vol/bind29
Udgave nummer17
Sider (fra-til)2315-22
Antal sider8
ISSN0269-9370
DOI
StatusUdgivet - nov. 2015

Fingeraftryk

Prostate
HIV
Fathers
Incidence
Confidence Intervals
Registries
Population
Cohort Studies

Citer dette

Ahlström, M. G., Kronborg, G., Larsen, C. S., Pedersen, C., Pedersen, G., Gerstoft, J., & Obel, N. (2015). Incidence of benign prostate hypertrophy in Danish men with and without HIV infection. AIDS, 29(17), 2315-22. https://doi.org/10.1097/QAD.0000000000000804
Ahlström, Magnus Glindvad ; Kronborg, Gitte ; Larsen, Carsten S ; Pedersen, Court ; Pedersen, Gitte ; Gerstoft, Jan ; Obel, Niels. / Incidence of benign prostate hypertrophy in Danish men with and without HIV infection. I: AIDS. 2015 ; Bind 29, Nr. 17. s. 2315-22.
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title = "Incidence of benign prostate hypertrophy in Danish men with and without HIV infection",
abstract = "BACKGROUND: Information on risk of benign prostate hypertrophy (BPH) in HIV-infected men is sparse. We aimed to estimate the incidence of being diagnosed with BPH among HIV-infected men compared with an age and sex-matched comparison cohort from the background population. To exclude that family-associated risk factors influence risk of BPH diagnoses in families of HIV-infected individuals, we estimated risk of BPH in fathers of HIV-infected men and fathers of the comparison cohort.METHODS: In a nationwide, population-based, matched cohort study, we calculated incidence rates and used Poisson regression models to calculate incidence rate ratios (IRRs) of being diagnosed with BPH, defined as the earliest of date of the second redeemed prescription of a drug used to treat BPH, the first registration of a BPH diagnosis in the Danish National Hospital Registry (DNHR) or the first registration of a surgical procedure for BPH in DNHR.RESULTS: We identified 4633 HIV-infected men, 46 330 comparison cohort individuals, 1585 fathers of HIV-infected men and 20 449 fathers of the comparison cohort. Incidence rate of being diagnosed with BPH was 37.0 [95{\%} confidence interval (95{\%} CI) 31.5-43.1] per 10 000 person-years of follow-up among HIV-infected men and was not increased compared with the comparison cohort (IRR 1.04, 95{\%} CI 0.88-1.22). Risk was not increased for fathers of HIV-infected men vs. fathers of the comparison cohort (IRR 0.99, 95{\%} CI 0.87-1.12). Stratified analyses did not change the above results markedly.CONCLUSION: HIV-infected individuals do not have an increased risk of being diagnosed with BPH.",
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Ahlström, MG, Kronborg, G, Larsen, CS, Pedersen, C, Pedersen, G, Gerstoft, J & Obel, N 2015, 'Incidence of benign prostate hypertrophy in Danish men with and without HIV infection', AIDS, bind 29, nr. 17, s. 2315-22. https://doi.org/10.1097/QAD.0000000000000804

Incidence of benign prostate hypertrophy in Danish men with and without HIV infection. / Ahlström, Magnus Glindvad; Kronborg, Gitte; Larsen, Carsten S; Pedersen, Court; Pedersen, Gitte; Gerstoft, Jan; Obel, Niels.

I: AIDS, Bind 29, Nr. 17, 11.2015, s. 2315-22.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Incidence of benign prostate hypertrophy in Danish men with and without HIV infection

AU - Ahlström, Magnus Glindvad

AU - Kronborg, Gitte

AU - Larsen, Carsten S

AU - Pedersen, Court

AU - Pedersen, Gitte

AU - Gerstoft, Jan

AU - Obel, Niels

PY - 2015/11

Y1 - 2015/11

N2 - BACKGROUND: Information on risk of benign prostate hypertrophy (BPH) in HIV-infected men is sparse. We aimed to estimate the incidence of being diagnosed with BPH among HIV-infected men compared with an age and sex-matched comparison cohort from the background population. To exclude that family-associated risk factors influence risk of BPH diagnoses in families of HIV-infected individuals, we estimated risk of BPH in fathers of HIV-infected men and fathers of the comparison cohort.METHODS: In a nationwide, population-based, matched cohort study, we calculated incidence rates and used Poisson regression models to calculate incidence rate ratios (IRRs) of being diagnosed with BPH, defined as the earliest of date of the second redeemed prescription of a drug used to treat BPH, the first registration of a BPH diagnosis in the Danish National Hospital Registry (DNHR) or the first registration of a surgical procedure for BPH in DNHR.RESULTS: We identified 4633 HIV-infected men, 46 330 comparison cohort individuals, 1585 fathers of HIV-infected men and 20 449 fathers of the comparison cohort. Incidence rate of being diagnosed with BPH was 37.0 [95% confidence interval (95% CI) 31.5-43.1] per 10 000 person-years of follow-up among HIV-infected men and was not increased compared with the comparison cohort (IRR 1.04, 95% CI 0.88-1.22). Risk was not increased for fathers of HIV-infected men vs. fathers of the comparison cohort (IRR 0.99, 95% CI 0.87-1.12). Stratified analyses did not change the above results markedly.CONCLUSION: HIV-infected individuals do not have an increased risk of being diagnosed with BPH.

AB - BACKGROUND: Information on risk of benign prostate hypertrophy (BPH) in HIV-infected men is sparse. We aimed to estimate the incidence of being diagnosed with BPH among HIV-infected men compared with an age and sex-matched comparison cohort from the background population. To exclude that family-associated risk factors influence risk of BPH diagnoses in families of HIV-infected individuals, we estimated risk of BPH in fathers of HIV-infected men and fathers of the comparison cohort.METHODS: In a nationwide, population-based, matched cohort study, we calculated incidence rates and used Poisson regression models to calculate incidence rate ratios (IRRs) of being diagnosed with BPH, defined as the earliest of date of the second redeemed prescription of a drug used to treat BPH, the first registration of a BPH diagnosis in the Danish National Hospital Registry (DNHR) or the first registration of a surgical procedure for BPH in DNHR.RESULTS: We identified 4633 HIV-infected men, 46 330 comparison cohort individuals, 1585 fathers of HIV-infected men and 20 449 fathers of the comparison cohort. Incidence rate of being diagnosed with BPH was 37.0 [95% confidence interval (95% CI) 31.5-43.1] per 10 000 person-years of follow-up among HIV-infected men and was not increased compared with the comparison cohort (IRR 1.04, 95% CI 0.88-1.22). Risk was not increased for fathers of HIV-infected men vs. fathers of the comparison cohort (IRR 0.99, 95% CI 0.87-1.12). Stratified analyses did not change the above results markedly.CONCLUSION: HIV-infected individuals do not have an increased risk of being diagnosed with BPH.

U2 - 10.1097/QAD.0000000000000804

DO - 10.1097/QAD.0000000000000804

M3 - Journal article

C2 - 26544703

VL - 29

SP - 2315

EP - 2322

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 17

ER -