Incidence and regional variation of Ankylosing Spondylitis and Spondyloarthritis 2000-2013: A nationwide cohort study

Publikation: Konferencebidrag uden forlag/tidsskriftPosterFormidling


Background: Spondyloarthritis is a group of inflammatory rheumatic diseases with Ankylosing Spondylitis (AS) as the major subgroup. Only a few studies worldwide have reported incidences of AS and their trend over time.

Objectives: To describe the incidences of Ankylosing Spondylitis (AS) and spondyloarthritis (SpA) in the Danish population in 2000–2013, at both national and regional level. To establish if there is a trend in incident cases over time and test if such a trend may be explained by use of MRI scans for diagnostic evaluation.

Methods: In the Danish National Patient Registry, we identified all patients with a valid Danish civil registration number who received an AS (ICD10:DM45) or SpA (ICD10:DM46) diagnosis during the time period from 1 January 2000 until 31 December 2013. Incident cases were identified and incidence rates described as rates per 1/100.000 of AS and SpA were calculated for each year. Variation among the five Danish regions were evaluated and correlated to the diagnostic use of MRI.

Results: We identified 3620 incident cases (AS: 2116, SpA: 1504). Males are overrepresented among AS incidents (58%–80%), both nationwide and regionally. The percentages of males with an AS diagnosis are stable throughout the time period (65%–69%). Females are overrepresented among SpA incidents nationwide and in most regions. In the Region of Southern Denmark, there is a small overrepresentation of males for both SpA and AS diagnoses (58%).

The number of nationwide AS incident cases increases between 2005 and 2009 from 534 (rate: 0.52) to 828 cases (0.82). During 2010–2013 the AS incidence decreased to 754 (0.94).

The number of SpA incident cases increased from 220 (0.21) in 2009 to 430 (0.43) in 2009 with an additional increase in incidence to 854 (1.06) in 2010–2013. The trend is the same throughout the five regions.

MRI was used for diagnostic purposes in only 10%–15% of the patients in 2002. In 2013 the number had increased to 95.0% of male patients and 94.3% of female patients diagnosed with AS and 98.5/98.1% of patients diagnosed with SpA.
Publikationsdato15. jun. 2018
StatusUdgivet - 15. jun. 2018
BegivenhedEULAR 2018 - Amsterdam, Holland
Varighed: 13. jun. 201816. jun. 2018


KonferenceEULAR 2018