Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark

C Torp-Pedersen, P Hildebrandt, L Køber, F E Nielsen, G Jensen, T Melchior, T Joen, V Ringsdal, U Nielsen, M Ege

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The aim of this investigation was to study secular trends in long-term survival following myocardial infarction (MI). Five thousand one hundred and fifty-seven consecutive cases of MI in 3942 patients were recorded in a well-defined region in the study period 1977-1988. The study period ended before thrombolytic therapy was introduced in the hospital. One and 5-year survival (+/- 95% confidence limits) was 61 +/- 2% and 42 +/- 2% in 1977-1980. These figures changed to 61 +/- 2% and 44 +/- 2% in 1981-1984, and to 64 +/- 2 and 46 +/- 2% in 1985-1988. The improvement with time was statistically significant (P < 0.001). In a Cox proportional hazard model, time of infarction was an independent predictor of survival. Patients were subdivided into a high risk group suffering from either congestive heart failure or cardiac arrest during hospitalization, and a low risk group without these complications. Year of infarction was without importance in the high risk group but highly significant in the low risk group. Long-term survival following MI gradually improved prior to the introduction of thrombolytic therapy. The improvement was confined to low risk patients without cardiac arrest or congestive heart failure.

OriginalsprogEngelsk
TidsskriftEuropean Heart Journal
Vol/bind16
Udgave nummer1
Sider (fra-til)14-20
ISSN0195-668X
StatusUdgivet - jan. 1995
Udgivet eksterntJa

Fingeraftryk

Denmark
Infarction
Proportional Hazards Models

Citer dette

Torp-Pedersen, C., Hildebrandt, P., Køber, L., Nielsen, F. E., Jensen, G., Melchior, T., ... Ege, M. (1995). Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark. European Heart Journal, 16(1), 14-20.
Torp-Pedersen, C ; Hildebrandt, P ; Køber, L ; Nielsen, F E ; Jensen, G ; Melchior, T ; Joen, T ; Ringsdal, V ; Nielsen, U ; Ege, M. / Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark. I: European Heart Journal. 1995 ; Bind 16, Nr. 1. s. 14-20.
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abstract = "The aim of this investigation was to study secular trends in long-term survival following myocardial infarction (MI). Five thousand one hundred and fifty-seven consecutive cases of MI in 3942 patients were recorded in a well-defined region in the study period 1977-1988. The study period ended before thrombolytic therapy was introduced in the hospital. One and 5-year survival (+/- 95{\%} confidence limits) was 61 +/- 2{\%} and 42 +/- 2{\%} in 1977-1980. These figures changed to 61 +/- 2{\%} and 44 +/- 2{\%} in 1981-1984, and to 64 +/- 2 and 46 +/- 2{\%} in 1985-1988. The improvement with time was statistically significant (P < 0.001). In a Cox proportional hazard model, time of infarction was an independent predictor of survival. Patients were subdivided into a high risk group suffering from either congestive heart failure or cardiac arrest during hospitalization, and a low risk group without these complications. Year of infarction was without importance in the high risk group but highly significant in the low risk group. Long-term survival following MI gradually improved prior to the introduction of thrombolytic therapy. The improvement was confined to low risk patients without cardiac arrest or congestive heart failure.",
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Torp-Pedersen, C, Hildebrandt, P, Køber, L, Nielsen, FE, Jensen, G, Melchior, T, Joen, T, Ringsdal, V, Nielsen, U & Ege, M 1995, 'Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark', European Heart Journal, bind 16, nr. 1, s. 14-20.

Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark. / Torp-Pedersen, C; Hildebrandt, P; Køber, L; Nielsen, F E; Jensen, G; Melchior, T; Joen, T; Ringsdal, V; Nielsen, U; Ege, M.

I: European Heart Journal, Bind 16, Nr. 1, 01.1995, s. 14-20.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark

AU - Torp-Pedersen, C

AU - Hildebrandt, P

AU - Køber, L

AU - Nielsen, F E

AU - Jensen, G

AU - Melchior, T

AU - Joen, T

AU - Ringsdal, V

AU - Nielsen, U

AU - Ege, M

PY - 1995/1

Y1 - 1995/1

N2 - The aim of this investigation was to study secular trends in long-term survival following myocardial infarction (MI). Five thousand one hundred and fifty-seven consecutive cases of MI in 3942 patients were recorded in a well-defined region in the study period 1977-1988. The study period ended before thrombolytic therapy was introduced in the hospital. One and 5-year survival (+/- 95% confidence limits) was 61 +/- 2% and 42 +/- 2% in 1977-1980. These figures changed to 61 +/- 2% and 44 +/- 2% in 1981-1984, and to 64 +/- 2 and 46 +/- 2% in 1985-1988. The improvement with time was statistically significant (P < 0.001). In a Cox proportional hazard model, time of infarction was an independent predictor of survival. Patients were subdivided into a high risk group suffering from either congestive heart failure or cardiac arrest during hospitalization, and a low risk group without these complications. Year of infarction was without importance in the high risk group but highly significant in the low risk group. Long-term survival following MI gradually improved prior to the introduction of thrombolytic therapy. The improvement was confined to low risk patients without cardiac arrest or congestive heart failure.

AB - The aim of this investigation was to study secular trends in long-term survival following myocardial infarction (MI). Five thousand one hundred and fifty-seven consecutive cases of MI in 3942 patients were recorded in a well-defined region in the study period 1977-1988. The study period ended before thrombolytic therapy was introduced in the hospital. One and 5-year survival (+/- 95% confidence limits) was 61 +/- 2% and 42 +/- 2% in 1977-1980. These figures changed to 61 +/- 2% and 44 +/- 2% in 1981-1984, and to 64 +/- 2 and 46 +/- 2% in 1985-1988. The improvement with time was statistically significant (P < 0.001). In a Cox proportional hazard model, time of infarction was an independent predictor of survival. Patients were subdivided into a high risk group suffering from either congestive heart failure or cardiac arrest during hospitalization, and a low risk group without these complications. Year of infarction was without importance in the high risk group but highly significant in the low risk group. Long-term survival following MI gradually improved prior to the introduction of thrombolytic therapy. The improvement was confined to low risk patients without cardiac arrest or congestive heart failure.

KW - Acute Disease

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Denmark

KW - Humans

KW - Middle Aged

KW - Myocardial Infarction

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Risk Factors

KW - Survival Rate

KW - Thrombolytic Therapy

KW - Journal Article

M3 - Journal article

VL - 16

SP - 14

EP - 20

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 1

ER -

Torp-Pedersen C, Hildebrandt P, Køber L, Nielsen FE, Jensen G, Melchior T et al. Improving long-term survival of patients with acute myocardial infarction from 1977-1988 in a region of Denmark. European Heart Journal. 1995 jan;16(1):14-20.