Improving health profile of blood donors as a consequence of transfusion safety efforts

Gustaf Edgren, Trung Nam Tran, Henrik Hjalgrim, Klaus Rostgaard, Agneta Shanwell, Kjell Titlestad, Agneta Wikman, Rut Norda, Casper Jersild, Louise Wideroff, Gloria Gridley, Johanna Adami, Mads Melbye, Olof Nyrén, Marie Reilly

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Transfusion safety rests heavily on the health of blood donors. Although they are perceived as being healthier than average, little is known about their long-term disease patterns and to which extent the blood banks' continuous efforts to optimize donor selection has resulted in improvements. Mortality and cancer incidence among blood donors in Sweden and Denmark was investigated. STUDY DESIGN AND METHODS: All computerized blood bank databases were compiled into one database, which was linked to national population and health data registers. With a retrospective cohort study design, 1,110,329 blood donors were followed for up to 35 years from first computer-registered blood donation to death, emigration, or December 31, 2002. Standardized mortality and incidence ratios expressed relative risk of death and cancer comparing blood donors to the general population. RESULTS: Blood donors had an overall mortality 30 percent lower (99% confidence interval [CI] 29%-31%) and cancer incidence 4 percent lower (99% CI 2%-5%) than the background population. Mortality rates and cancer incidence were lowest for outcomes that are recognized as being related to lifestyle factors such as smoking or to the selection criteria for blood donation. Blood donors recruited in more recent years exhibited a lower relative mortality than those who started earlier. CONCLUSION: Blood donors enjoy better than average health. Explicit and informal requirements for blood donation in Scandinavia, although mostly of a simple nature, have successfully refined the selection of a particularly healthy subpopulation
Udgivelsesdato: 2007-Nov
OriginalsprogEngelsk
TidsskriftTransfusion
Vol/bind47
Udgave nummer11
Sider (fra-til)2017-24
Antal sider8
ISSN0041-1132
DOI
StatusUdgivet - 1. nov. 2007

Citer dette

Edgren, G., Tran, T. N., Hjalgrim, H., Rostgaard, K., Shanwell, A., Titlestad, K., ... Reilly, M. (2007). Improving health profile of blood donors as a consequence of transfusion safety efforts. Transfusion, 47(11), 2017-24. https://doi.org/10.1111/j.1537-2995.2007.01425.x
Edgren, Gustaf ; Tran, Trung Nam ; Hjalgrim, Henrik ; Rostgaard, Klaus ; Shanwell, Agneta ; Titlestad, Kjell ; Wikman, Agneta ; Norda, Rut ; Jersild, Casper ; Wideroff, Louise ; Gridley, Gloria ; Adami, Johanna ; Melbye, Mads ; Nyrén, Olof ; Reilly, Marie. / Improving health profile of blood donors as a consequence of transfusion safety efforts. I: Transfusion. 2007 ; Bind 47, Nr. 11. s. 2017-24.
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title = "Improving health profile of blood donors as a consequence of transfusion safety efforts",
abstract = "BACKGROUND: Transfusion safety rests heavily on the health of blood donors. Although they are perceived as being healthier than average, little is known about their long-term disease patterns and to which extent the blood banks' continuous efforts to optimize donor selection has resulted in improvements. Mortality and cancer incidence among blood donors in Sweden and Denmark was investigated. STUDY DESIGN AND METHODS: All computerized blood bank databases were compiled into one database, which was linked to national population and health data registers. With a retrospective cohort study design, 1,110,329 blood donors were followed for up to 35 years from first computer-registered blood donation to death, emigration, or December 31, 2002. Standardized mortality and incidence ratios expressed relative risk of death and cancer comparing blood donors to the general population. RESULTS: Blood donors had an overall mortality 30 percent lower (99{\%} confidence interval [CI] 29{\%}-31{\%}) and cancer incidence 4 percent lower (99{\%} CI 2{\%}-5{\%}) than the background population. Mortality rates and cancer incidence were lowest for outcomes that are recognized as being related to lifestyle factors such as smoking or to the selection criteria for blood donation. Blood donors recruited in more recent years exhibited a lower relative mortality than those who started earlier. CONCLUSION: Blood donors enjoy better than average health. Explicit and informal requirements for blood donation in Scandinavia, although mostly of a simple nature, have successfully refined the selection of a particularly healthy subpopulation Udgivelsesdato: 2007-Nov",
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author = "Gustaf Edgren and Tran, {Trung Nam} and Henrik Hjalgrim and Klaus Rostgaard and Agneta Shanwell and Kjell Titlestad and Agneta Wikman and Rut Norda and Casper Jersild and Louise Wideroff and Gloria Gridley and Johanna Adami and Mads Melbye and Olof Nyr{\'e}n and Marie Reilly",
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Edgren, G, Tran, TN, Hjalgrim, H, Rostgaard, K, Shanwell, A, Titlestad, K, Wikman, A, Norda, R, Jersild, C, Wideroff, L, Gridley, G, Adami, J, Melbye, M, Nyrén, O & Reilly, M 2007, 'Improving health profile of blood donors as a consequence of transfusion safety efforts', Transfusion, bind 47, nr. 11, s. 2017-24. https://doi.org/10.1111/j.1537-2995.2007.01425.x

Improving health profile of blood donors as a consequence of transfusion safety efforts. / Edgren, Gustaf; Tran, Trung Nam; Hjalgrim, Henrik; Rostgaard, Klaus; Shanwell, Agneta; Titlestad, Kjell; Wikman, Agneta; Norda, Rut; Jersild, Casper; Wideroff, Louise; Gridley, Gloria; Adami, Johanna; Melbye, Mads; Nyrén, Olof; Reilly, Marie.

I: Transfusion, Bind 47, Nr. 11, 01.11.2007, s. 2017-24.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Improving health profile of blood donors as a consequence of transfusion safety efforts

AU - Edgren, Gustaf

AU - Tran, Trung Nam

AU - Hjalgrim, Henrik

AU - Rostgaard, Klaus

AU - Shanwell, Agneta

AU - Titlestad, Kjell

AU - Wikman, Agneta

AU - Norda, Rut

AU - Jersild, Casper

AU - Wideroff, Louise

AU - Gridley, Gloria

AU - Adami, Johanna

AU - Melbye, Mads

AU - Nyrén, Olof

AU - Reilly, Marie

PY - 2007/11/1

Y1 - 2007/11/1

N2 - BACKGROUND: Transfusion safety rests heavily on the health of blood donors. Although they are perceived as being healthier than average, little is known about their long-term disease patterns and to which extent the blood banks' continuous efforts to optimize donor selection has resulted in improvements. Mortality and cancer incidence among blood donors in Sweden and Denmark was investigated. STUDY DESIGN AND METHODS: All computerized blood bank databases were compiled into one database, which was linked to national population and health data registers. With a retrospective cohort study design, 1,110,329 blood donors were followed for up to 35 years from first computer-registered blood donation to death, emigration, or December 31, 2002. Standardized mortality and incidence ratios expressed relative risk of death and cancer comparing blood donors to the general population. RESULTS: Blood donors had an overall mortality 30 percent lower (99% confidence interval [CI] 29%-31%) and cancer incidence 4 percent lower (99% CI 2%-5%) than the background population. Mortality rates and cancer incidence were lowest for outcomes that are recognized as being related to lifestyle factors such as smoking or to the selection criteria for blood donation. Blood donors recruited in more recent years exhibited a lower relative mortality than those who started earlier. CONCLUSION: Blood donors enjoy better than average health. Explicit and informal requirements for blood donation in Scandinavia, although mostly of a simple nature, have successfully refined the selection of a particularly healthy subpopulation Udgivelsesdato: 2007-Nov

AB - BACKGROUND: Transfusion safety rests heavily on the health of blood donors. Although they are perceived as being healthier than average, little is known about their long-term disease patterns and to which extent the blood banks' continuous efforts to optimize donor selection has resulted in improvements. Mortality and cancer incidence among blood donors in Sweden and Denmark was investigated. STUDY DESIGN AND METHODS: All computerized blood bank databases were compiled into one database, which was linked to national population and health data registers. With a retrospective cohort study design, 1,110,329 blood donors were followed for up to 35 years from first computer-registered blood donation to death, emigration, or December 31, 2002. Standardized mortality and incidence ratios expressed relative risk of death and cancer comparing blood donors to the general population. RESULTS: Blood donors had an overall mortality 30 percent lower (99% confidence interval [CI] 29%-31%) and cancer incidence 4 percent lower (99% CI 2%-5%) than the background population. Mortality rates and cancer incidence were lowest for outcomes that are recognized as being related to lifestyle factors such as smoking or to the selection criteria for blood donation. Blood donors recruited in more recent years exhibited a lower relative mortality than those who started earlier. CONCLUSION: Blood donors enjoy better than average health. Explicit and informal requirements for blood donation in Scandinavia, although mostly of a simple nature, have successfully refined the selection of a particularly healthy subpopulation Udgivelsesdato: 2007-Nov

KW - Blood Donors

KW - Blood Transfusion

KW - Cohort Studies

KW - Denmark

KW - Health

KW - Humans

KW - Retrospective Studies

KW - Safety

KW - Sweden

U2 - 10.1111/j.1537-2995.2007.01425.x

DO - 10.1111/j.1537-2995.2007.01425.x

M3 - Journal article

C2 - 17958530

VL - 47

SP - 2017

EP - 2024

JO - Transfusion

JF - Transfusion

SN - 0041-1132

IS - 11

ER -