Improvement of brain tissue oxygenation by inhalation of carbogen

M Ashkanian, P Borghammer, A Gjedde, L Ostergaard, M Vafaee

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Hyperoxic therapy for cerebral ischemia is suspected to reduce cerebral blood flow (CBF), due to the vasoconstrictive effect of oxygen on cerebral arterioles. We hypothesized that vasodilation predominates when 5% CO(2) is added to the inhaled oxygen (carbogen). Therefore, we used positron emission tomography (PET) to measure CBF and cerebral metabolic rate of oxygen (CMRO(2)) during inhalation of test gases (O(2), CO(2), carbogen and atmospheric air) in 10 healthy volunteers. Arterial blood gases were recorded during administration of each gas. The data were analyzed with volume-of-interest and voxel-based statistical methods. Inhalation of CO(2) or carbogen significantly increased global CBF, whereas pure oxygen decreased global CBF. The CMRO(2) generally remained unchanged, except in white matter during oxygen inhalation relative to condition of atmospheric air inhalation. The volume-of-interest results were confirmed by statistical cluster analysis. Oxygen and carbogen were equally potent in increasing oxygen saturation of arterial blood (Sa(O2)). The present data demonstrate that inhalation of carbogen increases both CBF and Sa(O2) in healthy adults. In conclusion we speculate that carbogen inhalation is sufficient for optimal oxygenation of healthy brain tissue, whereas carbogen induces concomitant increases of CBF and Sa(O2).

OriginalsprogEngelsk
TidsskriftNeuroscience
Vol/bind156
Udgave nummer4
Sider (fra-til)932-8
Antal sider7
ISSN0306-4522
DOI
StatusUdgivet - 28. okt. 2008

Fingeraftryk

Oxygen
Gases
carbogen
Vasodilation
Cluster Analysis

Citer dette

Ashkanian, M ; Borghammer, P ; Gjedde, A ; Ostergaard, L ; Vafaee, M. / Improvement of brain tissue oxygenation by inhalation of carbogen. I: Neuroscience. 2008 ; Bind 156, Nr. 4. s. 932-8.
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abstract = "Hyperoxic therapy for cerebral ischemia is suspected to reduce cerebral blood flow (CBF), due to the vasoconstrictive effect of oxygen on cerebral arterioles. We hypothesized that vasodilation predominates when 5{\%} CO(2) is added to the inhaled oxygen (carbogen). Therefore, we used positron emission tomography (PET) to measure CBF and cerebral metabolic rate of oxygen (CMRO(2)) during inhalation of test gases (O(2), CO(2), carbogen and atmospheric air) in 10 healthy volunteers. Arterial blood gases were recorded during administration of each gas. The data were analyzed with volume-of-interest and voxel-based statistical methods. Inhalation of CO(2) or carbogen significantly increased global CBF, whereas pure oxygen decreased global CBF. The CMRO(2) generally remained unchanged, except in white matter during oxygen inhalation relative to condition of atmospheric air inhalation. The volume-of-interest results were confirmed by statistical cluster analysis. Oxygen and carbogen were equally potent in increasing oxygen saturation of arterial blood (Sa(O2)). The present data demonstrate that inhalation of carbogen increases both CBF and Sa(O2) in healthy adults. In conclusion we speculate that carbogen inhalation is sufficient for optimal oxygenation of healthy brain tissue, whereas carbogen induces concomitant increases of CBF and Sa(O2).",
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Improvement of brain tissue oxygenation by inhalation of carbogen. / Ashkanian, M; Borghammer, P; Gjedde, A; Ostergaard, L; Vafaee, M.

I: Neuroscience, Bind 156, Nr. 4, 28.10.2008, s. 932-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Improvement of brain tissue oxygenation by inhalation of carbogen

AU - Ashkanian, M

AU - Borghammer, P

AU - Gjedde, A

AU - Ostergaard, L

AU - Vafaee, M

PY - 2008/10/28

Y1 - 2008/10/28

N2 - Hyperoxic therapy for cerebral ischemia is suspected to reduce cerebral blood flow (CBF), due to the vasoconstrictive effect of oxygen on cerebral arterioles. We hypothesized that vasodilation predominates when 5% CO(2) is added to the inhaled oxygen (carbogen). Therefore, we used positron emission tomography (PET) to measure CBF and cerebral metabolic rate of oxygen (CMRO(2)) during inhalation of test gases (O(2), CO(2), carbogen and atmospheric air) in 10 healthy volunteers. Arterial blood gases were recorded during administration of each gas. The data were analyzed with volume-of-interest and voxel-based statistical methods. Inhalation of CO(2) or carbogen significantly increased global CBF, whereas pure oxygen decreased global CBF. The CMRO(2) generally remained unchanged, except in white matter during oxygen inhalation relative to condition of atmospheric air inhalation. The volume-of-interest results were confirmed by statistical cluster analysis. Oxygen and carbogen were equally potent in increasing oxygen saturation of arterial blood (Sa(O2)). The present data demonstrate that inhalation of carbogen increases both CBF and Sa(O2) in healthy adults. In conclusion we speculate that carbogen inhalation is sufficient for optimal oxygenation of healthy brain tissue, whereas carbogen induces concomitant increases of CBF and Sa(O2).

AB - Hyperoxic therapy for cerebral ischemia is suspected to reduce cerebral blood flow (CBF), due to the vasoconstrictive effect of oxygen on cerebral arterioles. We hypothesized that vasodilation predominates when 5% CO(2) is added to the inhaled oxygen (carbogen). Therefore, we used positron emission tomography (PET) to measure CBF and cerebral metabolic rate of oxygen (CMRO(2)) during inhalation of test gases (O(2), CO(2), carbogen and atmospheric air) in 10 healthy volunteers. Arterial blood gases were recorded during administration of each gas. The data were analyzed with volume-of-interest and voxel-based statistical methods. Inhalation of CO(2) or carbogen significantly increased global CBF, whereas pure oxygen decreased global CBF. The CMRO(2) generally remained unchanged, except in white matter during oxygen inhalation relative to condition of atmospheric air inhalation. The volume-of-interest results were confirmed by statistical cluster analysis. Oxygen and carbogen were equally potent in increasing oxygen saturation of arterial blood (Sa(O2)). The present data demonstrate that inhalation of carbogen increases both CBF and Sa(O2) in healthy adults. In conclusion we speculate that carbogen inhalation is sufficient for optimal oxygenation of healthy brain tissue, whereas carbogen induces concomitant increases of CBF and Sa(O2).

KW - Adult

KW - Aged

KW - Blood Flow Velocity

KW - Blood Gas Analysis

KW - Brain/anatomy & histology

KW - Brain Chemistry

KW - Brain Mapping

KW - Carbon Dioxide/administration & dosage

KW - Cerebrovascular Circulation/physiology

KW - Female

KW - Humans

KW - Inhalation

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Middle Aged

KW - Oxygen/administration & dosage

KW - Oxygen Radioisotopes/metabolism

KW - Positron-Emission Tomography

KW - Radiation-Sensitizing Agents/administration & dosage

U2 - 10.1016/j.neuroscience.2008.08.016

DO - 10.1016/j.neuroscience.2008.08.016

M3 - Journal article

C2 - 18786619

VL - 156

SP - 932

EP - 938

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 4

ER -