Important options available - from start to finish -for translating proteomics results to clinical chemistry

Niels H H Heegaard, Ole Ostergaard, Justyna M C Bahl, Martin Overgaard, Hans Christian Beck, Lars Melholt Rasmussen, Martin R Larsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

In the realm of clinical chemistry the field of clinical proteomics, i.e., the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feed assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftProteomics - Clinical Applications
Vol/bind9
Udgave nummer1-2
Sider (fra-til)235-252
ISSN1862-8346
DOI
StatusUdgivet - 2015

Fingeraftryk

Clinical Chemistry
Assays
Stretching
Proteomics
Planning
Research

Citer dette

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title = "Important options available - from start to finish -for translating proteomics results to clinical chemistry",
abstract = "In the realm of clinical chemistry the field of clinical proteomics, i.e., the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feed assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry. This article is protected by copyright. All rights reserved.",
author = "Heegaard, {Niels H H} and Ole Ostergaard and Bahl, {Justyna M C} and Martin Overgaard and Beck, {Hans Christian} and Rasmussen, {Lars Melholt} and Larsen, {Martin R}",
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year = "2015",
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Important options available - from start to finish -for translating proteomics results to clinical chemistry. / Heegaard, Niels H H; Ostergaard, Ole; Bahl, Justyna M C; Overgaard, Martin; Beck, Hans Christian; Rasmussen, Lars Melholt; Larsen, Martin R.

I: Proteomics - Clinical Applications, Bind 9, Nr. 1-2, 2015, s. 235-252.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Important options available - from start to finish -for translating proteomics results to clinical chemistry

AU - Heegaard, Niels H H

AU - Ostergaard, Ole

AU - Bahl, Justyna M C

AU - Overgaard, Martin

AU - Beck, Hans Christian

AU - Rasmussen, Lars Melholt

AU - Larsen, Martin R

N1 - This article is protected by copyright. All rights reserved.

PY - 2015

Y1 - 2015

N2 - In the realm of clinical chemistry the field of clinical proteomics, i.e., the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feed assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry. This article is protected by copyright. All rights reserved.

AB - In the realm of clinical chemistry the field of clinical proteomics, i.e., the application of proteomic methods for understanding mechanisms and enabling diagnosis, prediction, measurement of activity, and treatment response in disease, is first and foremost a discovery and research tool that feed assay development downstream. Putative new assay candidates generated by proteomics discovery projects compete with well-established assays with known indications, well-described performance, and of known value in specific clinical settings. Careful attention to the many options available in the design, execution, and interpretation of clinical proteomics studies is thus necessary for translation into clinical practice. We here review and discuss important options associated with clinical proteomics endeavors stretching from the planning phases to the final use in clinical chemistry. This article is protected by copyright. All rights reserved.

U2 - 10.1002/prca.201400137

DO - 10.1002/prca.201400137

M3 - Journal article

C2 - 25472910

VL - 9

SP - 235

EP - 252

JO - Proteomics - Clinical Applications

JF - Proteomics - Clinical Applications

SN - 1862-8346

IS - 1-2

ER -