Importance of the main chain of lysine for histone lysine methyltransferase catalysis

Abbas H. K. Al Temimi, Ruben S. Teeuwen, Vu Tran, Arthur J. Altunc, Danny C. Lenstra, Wansheng Ren, Ping Qian, Hong Guo, Jasmin Mecinović*

*Kontaktforfatter for dette arbejde

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Abstrakt

Histone lysine methyltransferases (KMTs) are biomedicinally important class of epigenetic enzymes that catalyse methylation of lysine residues in histones and other proteins. Enzymatic and computational studies on the simplest lysine analogues that possess a modified main chain demonstrate that the lysine's backbone contributes significantly to functional KMT binding and catalysis.
OriginalsprogEngelsk
TidsskriftOrganic & Biomolecular Chemistry
Vol/bind17
Udgave nummer23
Sider (fra-til)5693-5697
Antal sider5
ISSN1477-0520
DOI
StatusUdgivet - 2019

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