Impaired renal allograft function is associated with increased arterial stiffness in renal transplant recipients

M Kneifel, A Scholze, A Burkert, G Offermann, L Rothermund, W Zidek, Martin Tepel

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

It is important whether impairment of renal allograft function may deteriorate arterial stiffness in renal transplant recipients. In a cross-sectional study, arterial vascular characteristics were non-invasively determined in 48 patients with renal allograft using applanation tonometry and digital photoplethysmography. Mean age was 51 +/- 2 years (mean +/- SEM), and studies were performed 17 +/- 1 months after transplantation. The stage of chronic kidney disease was based on the glomerular filtration rate. We observed a significant association between the stage of chronic kidney disease and arterial stiffness of large arteries S1 and small arteries S2 in renal transplant recipients (each p <0.05 by non-parametric Kruskal-Wallis test between groups). Multivariate linear regression analysis showed that male gender of patients with renal allograft (p <0.01) reduced glomerular filtration rate (p = 0.01), and older age of kidney donor (p = 0.04) were independently associated with an increase of large artery stiffness S1. Furthermore, a significant association between the stage of chronic kidney disease and arterial vascular reactivity during reactive hyperemia was observed (p <0.05 by non-parametric Kruskal-Wallis test between groups). It is concluded that impairment of renal allograft function is associated with an increased arterial stiffness in renal transplant recipients.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Transplantation
Vol/bind6
Udgave nummer7
Sider (fra-til)1624-30
Antal sider7
ISSN1600-6135
DOI
StatusUdgivet - 2006

Fingeraftryk

Vascular Stiffness
Allografts
Kidney
Glomerular Filtration Rate
Photoplethysmography
Hyperemia
Manometry
Linear Models
Cross-Sectional Studies
Regression Analysis

Citer dette

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title = "Impaired renal allograft function is associated with increased arterial stiffness in renal transplant recipients",
abstract = "It is important whether impairment of renal allograft function may deteriorate arterial stiffness in renal transplant recipients. In a cross-sectional study, arterial vascular characteristics were non-invasively determined in 48 patients with renal allograft using applanation tonometry and digital photoplethysmography. Mean age was 51 +/- 2 years (mean +/- SEM), and studies were performed 17 +/- 1 months after transplantation. The stage of chronic kidney disease was based on the glomerular filtration rate. We observed a significant association between the stage of chronic kidney disease and arterial stiffness of large arteries S1 and small arteries S2 in renal transplant recipients (each p <0.05 by non-parametric Kruskal-Wallis test between groups). Multivariate linear regression analysis showed that male gender of patients with renal allograft (p <0.01) reduced glomerular filtration rate (p = 0.01), and older age of kidney donor (p = 0.04) were independently associated with an increase of large artery stiffness S1. Furthermore, a significant association between the stage of chronic kidney disease and arterial vascular reactivity during reactive hyperemia was observed (p <0.05 by non-parametric Kruskal-Wallis test between groups). It is concluded that impairment of renal allograft function is associated with an increased arterial stiffness in renal transplant recipients.",
keywords = "Adult, Cross-Sectional Studies, Female, Humans, Kidney, Kidney Transplantation, Male, Middle Aged, Transplantation, Homologous",
author = "M Kneifel and A Scholze and A Burkert and G Offermann and L Rothermund and W Zidek and Martin Tepel",
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Impaired renal allograft function is associated with increased arterial stiffness in renal transplant recipients. / Kneifel, M; Scholze, A; Burkert, A; Offermann, G; Rothermund, L; Zidek, W; Tepel, Martin.

I: American Journal of Transplantation, Bind 6, Nr. 7, 2006, s. 1624-30.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Impaired renal allograft function is associated with increased arterial stiffness in renal transplant recipients

AU - Kneifel, M

AU - Scholze, A

AU - Burkert, A

AU - Offermann, G

AU - Rothermund, L

AU - Zidek, W

AU - Tepel, Martin

PY - 2006

Y1 - 2006

N2 - It is important whether impairment of renal allograft function may deteriorate arterial stiffness in renal transplant recipients. In a cross-sectional study, arterial vascular characteristics were non-invasively determined in 48 patients with renal allograft using applanation tonometry and digital photoplethysmography. Mean age was 51 +/- 2 years (mean +/- SEM), and studies were performed 17 +/- 1 months after transplantation. The stage of chronic kidney disease was based on the glomerular filtration rate. We observed a significant association between the stage of chronic kidney disease and arterial stiffness of large arteries S1 and small arteries S2 in renal transplant recipients (each p <0.05 by non-parametric Kruskal-Wallis test between groups). Multivariate linear regression analysis showed that male gender of patients with renal allograft (p <0.01) reduced glomerular filtration rate (p = 0.01), and older age of kidney donor (p = 0.04) were independently associated with an increase of large artery stiffness S1. Furthermore, a significant association between the stage of chronic kidney disease and arterial vascular reactivity during reactive hyperemia was observed (p <0.05 by non-parametric Kruskal-Wallis test between groups). It is concluded that impairment of renal allograft function is associated with an increased arterial stiffness in renal transplant recipients.

AB - It is important whether impairment of renal allograft function may deteriorate arterial stiffness in renal transplant recipients. In a cross-sectional study, arterial vascular characteristics were non-invasively determined in 48 patients with renal allograft using applanation tonometry and digital photoplethysmography. Mean age was 51 +/- 2 years (mean +/- SEM), and studies were performed 17 +/- 1 months after transplantation. The stage of chronic kidney disease was based on the glomerular filtration rate. We observed a significant association between the stage of chronic kidney disease and arterial stiffness of large arteries S1 and small arteries S2 in renal transplant recipients (each p <0.05 by non-parametric Kruskal-Wallis test between groups). Multivariate linear regression analysis showed that male gender of patients with renal allograft (p <0.01) reduced glomerular filtration rate (p = 0.01), and older age of kidney donor (p = 0.04) were independently associated with an increase of large artery stiffness S1. Furthermore, a significant association between the stage of chronic kidney disease and arterial vascular reactivity during reactive hyperemia was observed (p <0.05 by non-parametric Kruskal-Wallis test between groups). It is concluded that impairment of renal allograft function is associated with an increased arterial stiffness in renal transplant recipients.

KW - Adult

KW - Cross-Sectional Studies

KW - Female

KW - Humans

KW - Kidney

KW - Kidney Transplantation

KW - Male

KW - Middle Aged

KW - Transplantation, Homologous

U2 - 10.1111/j.1600-6143.2006.01341.x

DO - 10.1111/j.1600-6143.2006.01341.x

M3 - Journal article

C2 - 16827863

VL - 6

SP - 1624

EP - 1630

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 7

ER -