Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training

B F Vind, C Pehmøller, J T Treebak, J B Birk, M Hey-Mogensen, H Beck-Nielsen, J R Zierath, Jørgen Wojtaszewski, K Højlund

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Insulin-mediated glucose disposal rates (R(d)) are reduced in type 2 diabetic patients, a process in which intrinsic signalling defects are thought to be involved. Phosphorylation of TBC1 domain family, member 4 (TBC1D4) is at present the most distal insulin receptor signalling event linked to glucose transport. In this study, we examined insulin action on site-specific phosphorylation of TBC1D4 and the effect of exercise training on insulin action and signalling to TBC1D4 in skeletal muscle from type 2 diabetic patients.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind54
Udgave nummer1
Sider (fra-til)157-167
ISSN0012-186X
DOI
StatusUdgivet - 2011

Fingeraftryk

Type 2 Diabetes Mellitus
Skeletal Muscle
Exercise
Insulin
Insulin Receptor

Citer dette

Vind, B F ; Pehmøller, C ; Treebak, J T ; Birk, J B ; Hey-Mogensen, M ; Beck-Nielsen, H ; Zierath, J R ; Wojtaszewski, Jørgen ; Højlund, K. / Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training. I: Diabetologia. 2011 ; Bind 54, Nr. 1. s. 157-167.
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title = "Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training",
abstract = "Insulin-mediated glucose disposal rates (R(d)) are reduced in type 2 diabetic patients, a process in which intrinsic signalling defects are thought to be involved. Phosphorylation of TBC1 domain family, member 4 (TBC1D4) is at present the most distal insulin receptor signalling event linked to glucose transport. In this study, we examined insulin action on site-specific phosphorylation of TBC1D4 and the effect of exercise training on insulin action and signalling to TBC1D4 in skeletal muscle from type 2 diabetic patients.",
keywords = "Blood Glucose, Blotting, Western, C-Peptide, Diabetes Mellitus, Type 2, Electrophoresis, Polyacrylamide Gel, Exercise, GTPase-Activating Proteins, Glucose Clamp Technique, Glycogen Synthase, Hemoglobin A, Glycosylated, Humans, Insulin, Male, Middle Aged, Muscle, Skeletal, Phosphorylation",
author = "Vind, {B F} and C Pehm{\o}ller and Treebak, {J T} and Birk, {J B} and M Hey-Mogensen and H Beck-Nielsen and Zierath, {J R} and J{\o}rgen Wojtaszewski and K H{\o}jlund",
year = "2011",
doi = "10.1007/s00125-010-1924-4",
language = "English",
volume = "54",
pages = "157--167",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Heinemann",
number = "1",

}

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training. / Vind, B F; Pehmøller, C; Treebak, J T; Birk, J B; Hey-Mogensen, M; Beck-Nielsen, H; Zierath, J R; Wojtaszewski, Jørgen; Højlund, K.

I: Diabetologia, Bind 54, Nr. 1, 2011, s. 157-167.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training

AU - Vind, B F

AU - Pehmøller, C

AU - Treebak, J T

AU - Birk, J B

AU - Hey-Mogensen, M

AU - Beck-Nielsen, H

AU - Zierath, J R

AU - Wojtaszewski, Jørgen

AU - Højlund, K

PY - 2011

Y1 - 2011

N2 - Insulin-mediated glucose disposal rates (R(d)) are reduced in type 2 diabetic patients, a process in which intrinsic signalling defects are thought to be involved. Phosphorylation of TBC1 domain family, member 4 (TBC1D4) is at present the most distal insulin receptor signalling event linked to glucose transport. In this study, we examined insulin action on site-specific phosphorylation of TBC1D4 and the effect of exercise training on insulin action and signalling to TBC1D4 in skeletal muscle from type 2 diabetic patients.

AB - Insulin-mediated glucose disposal rates (R(d)) are reduced in type 2 diabetic patients, a process in which intrinsic signalling defects are thought to be involved. Phosphorylation of TBC1 domain family, member 4 (TBC1D4) is at present the most distal insulin receptor signalling event linked to glucose transport. In this study, we examined insulin action on site-specific phosphorylation of TBC1D4 and the effect of exercise training on insulin action and signalling to TBC1D4 in skeletal muscle from type 2 diabetic patients.

KW - Blood Glucose

KW - Blotting, Western

KW - C-Peptide

KW - Diabetes Mellitus, Type 2

KW - Electrophoresis, Polyacrylamide Gel

KW - Exercise

KW - GTPase-Activating Proteins

KW - Glucose Clamp Technique

KW - Glycogen Synthase

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

KW - Phosphorylation

U2 - 10.1007/s00125-010-1924-4

DO - 10.1007/s00125-010-1924-4

M3 - Journal article

C2 - 20938636

VL - 54

SP - 157

EP - 167

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 1

ER -