Impact of particulate matter on mothers and babies in Antwerp (IPANEMA)

a prospective cohort study on the impact of pollutants and particulate matter in pregnancy

Lena Van den Eeden, Nathalie Lambrechts, Veerle Verheyen, Mario Berth, Greet Schoeters, Yves Jacquemyn

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

INTRODUCTION: Air pollution is a hot topic and is known to cause multiple health issues. Especially pregnant women seem to be vulnerable to environmental issues. There are data suggesting that exposure contributes to hypertensive disorders.This study aims to evaluate the effects of exposure to particulate matter (PM) and outdoor air pollutants on the clinical pregnancy outcome for mother and child and to determine which biochemical changes in maternal, placental and cord blood best explain this effect.

METHODS AND ANALYSIS: This study is a prospective cohort study. We aim to recruit 200 pregnant women. The outcome measurements will include maternal parameters, labour parameters and neonatal parameters.Multiple samples will be analysed such as maternal urine samples (8-oxo-deoxyguanosine), maternal blood samples (routine blood sampling, biomarkers of pre-eclampsia and transcript markers), maternal hair samples, neonatal blood samples (transcript markers) combined with extensive questionnaires.

ETHICS AND DISSEMINATION: We obtain informed consent from each participant prior to enrolment in the study.The study has received approval by the Ethical Committee of the Antwerp University Hospital (14/40/411).IPANEMA is the first prospective study to assess the impact of PM on mothers and babies in Antwerp, Belgium.Findings from this study will contribute to improve knowledge on the impact of exposure to air pollution on mothers and babies and will also define biomarkers as predictors for pregnant women at risk.

TRIAL REGISTRATION: ClinicalTrials.gov: 14/40/411. Registered 22-10-2015.

OriginalsprogEngelsk
Artikelnummere020028
TidsskriftBMJ Open
Vol/bind8
Udgave nummer3
Antal sider6
ISSN2044-6055
DOI
StatusUdgivet - 2018

Fingeraftryk

Particulate Matter
Cohort Studies
Mothers
Prospective Studies
Pregnant Women
Air Pollution
Air Pollutants
Deoxyguanosine
Pre-Eclampsia
Informed Consent
Fetal Blood
Hair
Urine
Health

Citer dette

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title = "Impact of particulate matter on mothers and babies in Antwerp (IPANEMA): a prospective cohort study on the impact of pollutants and particulate matter in pregnancy",
abstract = "INTRODUCTION: Air pollution is a hot topic and is known to cause multiple health issues. Especially pregnant women seem to be vulnerable to environmental issues. There are data suggesting that exposure contributes to hypertensive disorders.This study aims to evaluate the effects of exposure to particulate matter (PM) and outdoor air pollutants on the clinical pregnancy outcome for mother and child and to determine which biochemical changes in maternal, placental and cord blood best explain this effect.METHODS AND ANALYSIS: This study is a prospective cohort study. We aim to recruit 200 pregnant women. The outcome measurements will include maternal parameters, labour parameters and neonatal parameters.Multiple samples will be analysed such as maternal urine samples (8-oxo-deoxyguanosine), maternal blood samples (routine blood sampling, biomarkers of pre-eclampsia and transcript markers), maternal hair samples, neonatal blood samples (transcript markers) combined with extensive questionnaires.ETHICS AND DISSEMINATION: We obtain informed consent from each participant prior to enrolment in the study.The study has received approval by the Ethical Committee of the Antwerp University Hospital (14/40/411).IPANEMA is the first prospective study to assess the impact of PM on mothers and babies in Antwerp, Belgium.Findings from this study will contribute to improve knowledge on the impact of exposure to air pollution on mothers and babies and will also define biomarkers as predictors for pregnant women at risk.TRIAL REGISTRATION: ClinicalTrials.gov: 14/40/411. Registered 22-10-2015.",
author = "{Van den Eeden}, Lena and Nathalie Lambrechts and Veerle Verheyen and Mario Berth and Greet Schoeters and Yves Jacquemyn",
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Impact of particulate matter on mothers and babies in Antwerp (IPANEMA) : a prospective cohort study on the impact of pollutants and particulate matter in pregnancy. / Van den Eeden, Lena; Lambrechts, Nathalie; Verheyen, Veerle; Berth, Mario; Schoeters, Greet; Jacquemyn, Yves.

I: BMJ Open, Bind 8, Nr. 3, e020028, 2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Impact of particulate matter on mothers and babies in Antwerp (IPANEMA)

T2 - a prospective cohort study on the impact of pollutants and particulate matter in pregnancy

AU - Van den Eeden, Lena

AU - Lambrechts, Nathalie

AU - Verheyen, Veerle

AU - Berth, Mario

AU - Schoeters, Greet

AU - Jacquemyn, Yves

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018

Y1 - 2018

N2 - INTRODUCTION: Air pollution is a hot topic and is known to cause multiple health issues. Especially pregnant women seem to be vulnerable to environmental issues. There are data suggesting that exposure contributes to hypertensive disorders.This study aims to evaluate the effects of exposure to particulate matter (PM) and outdoor air pollutants on the clinical pregnancy outcome for mother and child and to determine which biochemical changes in maternal, placental and cord blood best explain this effect.METHODS AND ANALYSIS: This study is a prospective cohort study. We aim to recruit 200 pregnant women. The outcome measurements will include maternal parameters, labour parameters and neonatal parameters.Multiple samples will be analysed such as maternal urine samples (8-oxo-deoxyguanosine), maternal blood samples (routine blood sampling, biomarkers of pre-eclampsia and transcript markers), maternal hair samples, neonatal blood samples (transcript markers) combined with extensive questionnaires.ETHICS AND DISSEMINATION: We obtain informed consent from each participant prior to enrolment in the study.The study has received approval by the Ethical Committee of the Antwerp University Hospital (14/40/411).IPANEMA is the first prospective study to assess the impact of PM on mothers and babies in Antwerp, Belgium.Findings from this study will contribute to improve knowledge on the impact of exposure to air pollution on mothers and babies and will also define biomarkers as predictors for pregnant women at risk.TRIAL REGISTRATION: ClinicalTrials.gov: 14/40/411. Registered 22-10-2015.

AB - INTRODUCTION: Air pollution is a hot topic and is known to cause multiple health issues. Especially pregnant women seem to be vulnerable to environmental issues. There are data suggesting that exposure contributes to hypertensive disorders.This study aims to evaluate the effects of exposure to particulate matter (PM) and outdoor air pollutants on the clinical pregnancy outcome for mother and child and to determine which biochemical changes in maternal, placental and cord blood best explain this effect.METHODS AND ANALYSIS: This study is a prospective cohort study. We aim to recruit 200 pregnant women. The outcome measurements will include maternal parameters, labour parameters and neonatal parameters.Multiple samples will be analysed such as maternal urine samples (8-oxo-deoxyguanosine), maternal blood samples (routine blood sampling, biomarkers of pre-eclampsia and transcript markers), maternal hair samples, neonatal blood samples (transcript markers) combined with extensive questionnaires.ETHICS AND DISSEMINATION: We obtain informed consent from each participant prior to enrolment in the study.The study has received approval by the Ethical Committee of the Antwerp University Hospital (14/40/411).IPANEMA is the first prospective study to assess the impact of PM on mothers and babies in Antwerp, Belgium.Findings from this study will contribute to improve knowledge on the impact of exposure to air pollution on mothers and babies and will also define biomarkers as predictors for pregnant women at risk.TRIAL REGISTRATION: ClinicalTrials.gov: 14/40/411. Registered 22-10-2015.

U2 - 10.1136/bmjopen-2017-020028

DO - 10.1136/bmjopen-2017-020028

M3 - Journal article

VL - 8

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 3

M1 - e020028

ER -