Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau

Olga Bengård Hansen, Amabelia Rodrigues, Cesario Martins, Andreas Rieckmann, Christine Stabell Benn, Peter Aaby, Ane Bærent Fisker

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau.

METHODS: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status.

RESULTS: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect.

CONCLUSION: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.

OriginalsprogEngelsk
TidsskriftJournal of Tropical Pediatrics
Vol/bind65
Udgave nummer5
Sider (fra-til)446-456
ISSN0142-6338
DOI
StatusUdgivet - 1. okt. 2019

Fingeraftryk

Guinea-Bissau
Human Influenza
Referral and Consultation
Influenza Vaccines
Health
Proportional Hazards Models
Confidence Intervals

Bibliografisk note

© The Author(s) [2018]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Citer dette

Hansen, Olga Bengård ; Rodrigues, Amabelia ; Martins, Cesario ; Rieckmann, Andreas ; Benn, Christine Stabell ; Aaby, Peter ; Fisker, Ane Bærent. / Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau. I: Journal of Tropical Pediatrics. 2019 ; Bind 65, Nr. 5. s. 446-456.
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title = "Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau",
abstract = "BACKGROUND: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau.METHODS: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status.RESULTS: Among 10 290 children eligible for the campaign, 60{\%} had participated, 18{\%} had not and for 22{\%} no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95{\%} confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95{\%} CI: 0.58; 0.79)], p = 0.06 for same effect.CONCLUSION: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.",
author = "Hansen, {Olga Beng{\aa}rd} and Amabelia Rodrigues and Cesario Martins and Andreas Rieckmann and Benn, {Christine Stabell} and Peter Aaby and Fisker, {Ane B{\ae}rent}",
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Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau. / Hansen, Olga Bengård; Rodrigues, Amabelia; Martins, Cesario; Rieckmann, Andreas; Benn, Christine Stabell; Aaby, Peter; Fisker, Ane Bærent.

I: Journal of Tropical Pediatrics, Bind 65, Nr. 5, 01.10.2019, s. 446-456.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Impact of H1N1 Influenza Vaccination on Child Morbidity in Guinea-Bissau

AU - Hansen, Olga Bengård

AU - Rodrigues, Amabelia

AU - Martins, Cesario

AU - Rieckmann, Andreas

AU - Benn, Christine Stabell

AU - Aaby, Peter

AU - Fisker, Ane Bærent

N1 - © The Author(s) [2018]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - BACKGROUND: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau.METHODS: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status.RESULTS: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect.CONCLUSION: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.

AB - BACKGROUND: In addition to vaccines' specific effects, vaccines may have non-specific effects (NSEs) altering the susceptibility to unrelated infections. Non-live vaccines have been associated with negative NSEs. In 2010, a campaign with the non-live H1N1-influenza vaccine targeted children 6-59 months in Guinea-Bissau.METHODS: Bandim Health Project runs a health and demographic surveillance system site in Guinea-Bissau. Using a Cox proportional hazards model, we compared all-cause consultation rates after vs. before the campaign, stratified by participation status.RESULTS: Among 10 290 children eligible for the campaign, 60% had participated, 18% had not and for 22% no information was obtained. After the H1N1 campaign, the consultation rates tended to decline less for participants [HR = 0.80 (95% confidence interval, CI: 0.75; 0.85)] than for non-participants [HR = 0.68 (95% CI: 0.58; 0.79)], p = 0.06 for same effect.CONCLUSION: The decline in the vaccinated group may have been smaller than the decline in the non-vaccinated group consistent with H1N1-vaccine increasing susceptibility to unrelated infections.

U2 - 10.1093/tropej/fmy075

DO - 10.1093/tropej/fmy075

M3 - Journal article

C2 - 30590828

VL - 65

SP - 446

EP - 456

JO - Journal of Tropical Pediatrics

JF - Journal of Tropical Pediatrics

SN - 0142-6338

IS - 5

ER -