Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomised controlled trials

Alessio Bricca, Carsten B Juhl, Martijn Steultjens, Wolfgang Wirth, Ewa M Roos

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Resumé

OBJECTIVE: To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs).

DESIGN: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.

DATA SOURCES: We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials and Web of Science up to September 2017.

ELIGIBILITY CRITERIA: RCTs investigating the impact of exercise on MRI-assessed articular cartilage in people over 18 years of age.

RESULTS: We included nine trials, including a total of 14 comparisons of cartilage morphometry, morphology and composition outcomes, of which two included participants at increased risk of knee OA and 12 included participants with knee OA. In participants at increased risk, one study comparison reported no effect on cartilage defects and one had positive effects on glycosaminoglycans (GAG). In participants with OA, six study comparisons reported no effect on cartilage thickness, volume or defects; one reported a negative effect and one no effect on GAG; two reported a positive effect and two no effect on collagen.

CONCLUSIONS: Knee joint loading exercise seems to not be harmful for articular cartilage in people at increased risk of, or with, knee OA. However, the quality of evidence was low, including some interventions studying activities considered outside the therapeutic loading spectrum to promote cartilage health.

OriginalsprogEngelsk
TidsskriftBritish Journal of Sports Medicine
Vol/bind53
Udgave nummer15
Sider (fra-til)940-947
ISSN0306-3674
DOI
StatusUdgivet - aug. 2019

Fingeraftryk

Knee Osteoarthritis
Randomized Controlled Trials
Knee Joint
MEDLINE
Publications
Meta-Analysis
Language
Guidelines
Health

Citer dette

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title = "Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomised controlled trials",
abstract = "OBJECTIVE: To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs).DESIGN: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.DATA SOURCES: We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials and Web of Science up to September 2017.ELIGIBILITY CRITERIA: RCTs investigating the impact of exercise on MRI-assessed articular cartilage in people over 18 years of age.RESULTS: We included nine trials, including a total of 14 comparisons of cartilage morphometry, morphology and composition outcomes, of which two included participants at increased risk of knee OA and 12 included participants with knee OA. In participants at increased risk, one study comparison reported no effect on cartilage defects and one had positive effects on glycosaminoglycans (GAG). In participants with OA, six study comparisons reported no effect on cartilage thickness, volume or defects; one reported a negative effect and one no effect on GAG; two reported a positive effect and two no effect on collagen.CONCLUSIONS: Knee joint loading exercise seems to not be harmful for articular cartilage in people at increased risk of, or with, knee OA. However, the quality of evidence was low, including some interventions studying activities considered outside the therapeutic loading spectrum to promote cartilage health.",
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pages = "940--947",
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Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis : a systematic review of randomised controlled trials. / Bricca, Alessio; Juhl, Carsten B; Steultjens, Martijn; Wirth, Wolfgang; Roos, Ewa M.

I: British Journal of Sports Medicine, Bind 53, Nr. 15, 08.2019, s. 940-947.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis

T2 - a systematic review of randomised controlled trials

AU - Bricca, Alessio

AU - Juhl, Carsten B

AU - Steultjens, Martijn

AU - Wirth, Wolfgang

AU - Roos, Ewa M

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2019/8

Y1 - 2019/8

N2 - OBJECTIVE: To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs).DESIGN: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.DATA SOURCES: We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials and Web of Science up to September 2017.ELIGIBILITY CRITERIA: RCTs investigating the impact of exercise on MRI-assessed articular cartilage in people over 18 years of age.RESULTS: We included nine trials, including a total of 14 comparisons of cartilage morphometry, morphology and composition outcomes, of which two included participants at increased risk of knee OA and 12 included participants with knee OA. In participants at increased risk, one study comparison reported no effect on cartilage defects and one had positive effects on glycosaminoglycans (GAG). In participants with OA, six study comparisons reported no effect on cartilage thickness, volume or defects; one reported a negative effect and one no effect on GAG; two reported a positive effect and two no effect on collagen.CONCLUSIONS: Knee joint loading exercise seems to not be harmful for articular cartilage in people at increased risk of, or with, knee OA. However, the quality of evidence was low, including some interventions studying activities considered outside the therapeutic loading spectrum to promote cartilage health.

AB - OBJECTIVE: To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs).DESIGN: We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.DATA SOURCES: We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials and Web of Science up to September 2017.ELIGIBILITY CRITERIA: RCTs investigating the impact of exercise on MRI-assessed articular cartilage in people over 18 years of age.RESULTS: We included nine trials, including a total of 14 comparisons of cartilage morphometry, morphology and composition outcomes, of which two included participants at increased risk of knee OA and 12 included participants with knee OA. In participants at increased risk, one study comparison reported no effect on cartilage defects and one had positive effects on glycosaminoglycans (GAG). In participants with OA, six study comparisons reported no effect on cartilage thickness, volume or defects; one reported a negative effect and one no effect on GAG; two reported a positive effect and two no effect on collagen.CONCLUSIONS: Knee joint loading exercise seems to not be harmful for articular cartilage in people at increased risk of, or with, knee OA. However, the quality of evidence was low, including some interventions studying activities considered outside the therapeutic loading spectrum to promote cartilage health.

KW - cartilage

KW - collagen

KW - evidence based review

KW - exercise

KW - load

U2 - 10.1136/bjsports-2017-098661

DO - 10.1136/bjsports-2017-098661

M3 - Review

C2 - 29934429

VL - 53

SP - 940

EP - 947

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

IS - 15

ER -