Impact of age on the association between 24-h ambulatory blood pressure measurements and target organ damage

Thomas B Olesen, Manan Pareek, Jacob V Stidsen, Marie K Blicher, Susanne Rasmussen, Julie K K Vishram-Nielsen, Kathrine Kjaer-Hansen, Michael H Olsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective: The aim of this study was to evaluate the impact of age on the associations between hemodynamic components derived from 24-h ambulatory blood pressure (24-h ABPM) and target organ damage, in apparently healthy, nonmedicated individuals. Methods: Twenty-four-hour ABPM and target organ damage (left ventricular mass index, pulse wave velocity, urine albumin : Creatinine ratio and carotid atherosclerotic plaques) were evaluated in 1408 individuals. Associations were examined in regression models, stratified for age [middle-aged (41 or 51 years) or elderly (61 or 71 years)], and adjusted for sex, smoking status, and total-cholesterol. Results: In middle-aged individuals, an increase of 10mmHg in 24-h SBP was independently associated with an increase of 3.8 (2.7-4.8) g/m2 in LVMI. The effect was nearly doubled in the elderly subgroup, where the same increase resulted in an increase in LVMI of 6.3 (5.0-7.6) g/ m2 (P for interaction <0.01). An increase of 10mmHg of 24-h SBP was associated with a 6.7% increase in pulse wave velocity in middle-aged individuals and with an 9.1% increase in elderly individuals (P for interaction <0.01). An independent association between 24-h ABPM and urine albumin : Creatinine ratio was only observed in the elderly subgroup. Associations between the presence of atherosclerotic plaques and components from 24-h ABPM except 24-h DBP were not modified by age (all P for interaction >0.26). Conclusion: Age enhances the associations between hemodynamic components obtained from 24-h ABPM and measures of arterial stiffness, microvascular damage, and cardiac structure, but not atherosclerosis.

OriginalsprogEngelsk
TidsskriftJournal of Hypertension
Vol/bind36
Udgave nummer9
Sider (fra-til)1895-1901
ISSN0263-6352
DOI
StatusUdgivet - 1. sep. 2018

Fingeraftryk

Vascular Stiffness
Atherosclerotic Plaques
Albumins
Creatinine
Smoking
Urine

Citer dette

Olesen, Thomas B ; Pareek, Manan ; Stidsen, Jacob V ; Blicher, Marie K ; Rasmussen, Susanne ; Vishram-Nielsen, Julie K K ; Kjaer-Hansen, Kathrine ; Olsen, Michael H. / Impact of age on the association between 24-h ambulatory blood pressure measurements and target organ damage. I: Journal of Hypertension. 2018 ; Bind 36, Nr. 9. s. 1895-1901.
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title = "Impact of age on the association between 24-h ambulatory blood pressure measurements and target organ damage",
abstract = "Objective: The aim of this study was to evaluate the impact of age on the associations between hemodynamic components derived from 24-h ambulatory blood pressure (24-h ABPM) and target organ damage, in apparently healthy, nonmedicated individuals. Methods: Twenty-four-hour ABPM and target organ damage (left ventricular mass index, pulse wave velocity, urine albumin : Creatinine ratio and carotid atherosclerotic plaques) were evaluated in 1408 individuals. Associations were examined in regression models, stratified for age [middle-aged (41 or 51 years) or elderly (61 or 71 years)], and adjusted for sex, smoking status, and total-cholesterol. Results: In middle-aged individuals, an increase of 10mmHg in 24-h SBP was independently associated with an increase of 3.8 (2.7-4.8) g/m2 in LVMI. The effect was nearly doubled in the elderly subgroup, where the same increase resulted in an increase in LVMI of 6.3 (5.0-7.6) g/ m2 (P for interaction <0.01). An increase of 10mmHg of 24-h SBP was associated with a 6.7{\%} increase in pulse wave velocity in middle-aged individuals and with an 9.1{\%} increase in elderly individuals (P for interaction <0.01). An independent association between 24-h ABPM and urine albumin : Creatinine ratio was only observed in the elderly subgroup. Associations between the presence of atherosclerotic plaques and components from 24-h ABPM except 24-h DBP were not modified by age (all P for interaction >0.26). Conclusion: Age enhances the associations between hemodynamic components obtained from 24-h ABPM and measures of arterial stiffness, microvascular damage, and cardiac structure, but not atherosclerosis.",
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Impact of age on the association between 24-h ambulatory blood pressure measurements and target organ damage. / Olesen, Thomas B; Pareek, Manan; Stidsen, Jacob V; Blicher, Marie K; Rasmussen, Susanne; Vishram-Nielsen, Julie K K; Kjaer-Hansen, Kathrine; Olsen, Michael H.

I: Journal of Hypertension, Bind 36, Nr. 9, 01.09.2018, s. 1895-1901.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Impact of age on the association between 24-h ambulatory blood pressure measurements and target organ damage

AU - Olesen, Thomas B

AU - Pareek, Manan

AU - Stidsen, Jacob V

AU - Blicher, Marie K

AU - Rasmussen, Susanne

AU - Vishram-Nielsen, Julie K K

AU - Kjaer-Hansen, Kathrine

AU - Olsen, Michael H

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective: The aim of this study was to evaluate the impact of age on the associations between hemodynamic components derived from 24-h ambulatory blood pressure (24-h ABPM) and target organ damage, in apparently healthy, nonmedicated individuals. Methods: Twenty-four-hour ABPM and target organ damage (left ventricular mass index, pulse wave velocity, urine albumin : Creatinine ratio and carotid atherosclerotic plaques) were evaluated in 1408 individuals. Associations were examined in regression models, stratified for age [middle-aged (41 or 51 years) or elderly (61 or 71 years)], and adjusted for sex, smoking status, and total-cholesterol. Results: In middle-aged individuals, an increase of 10mmHg in 24-h SBP was independently associated with an increase of 3.8 (2.7-4.8) g/m2 in LVMI. The effect was nearly doubled in the elderly subgroup, where the same increase resulted in an increase in LVMI of 6.3 (5.0-7.6) g/ m2 (P for interaction <0.01). An increase of 10mmHg of 24-h SBP was associated with a 6.7% increase in pulse wave velocity in middle-aged individuals and with an 9.1% increase in elderly individuals (P for interaction <0.01). An independent association between 24-h ABPM and urine albumin : Creatinine ratio was only observed in the elderly subgroup. Associations between the presence of atherosclerotic plaques and components from 24-h ABPM except 24-h DBP were not modified by age (all P for interaction >0.26). Conclusion: Age enhances the associations between hemodynamic components obtained from 24-h ABPM and measures of arterial stiffness, microvascular damage, and cardiac structure, but not atherosclerosis.

AB - Objective: The aim of this study was to evaluate the impact of age on the associations between hemodynamic components derived from 24-h ambulatory blood pressure (24-h ABPM) and target organ damage, in apparently healthy, nonmedicated individuals. Methods: Twenty-four-hour ABPM and target organ damage (left ventricular mass index, pulse wave velocity, urine albumin : Creatinine ratio and carotid atherosclerotic plaques) were evaluated in 1408 individuals. Associations were examined in regression models, stratified for age [middle-aged (41 or 51 years) or elderly (61 or 71 years)], and adjusted for sex, smoking status, and total-cholesterol. Results: In middle-aged individuals, an increase of 10mmHg in 24-h SBP was independently associated with an increase of 3.8 (2.7-4.8) g/m2 in LVMI. The effect was nearly doubled in the elderly subgroup, where the same increase resulted in an increase in LVMI of 6.3 (5.0-7.6) g/ m2 (P for interaction <0.01). An increase of 10mmHg of 24-h SBP was associated with a 6.7% increase in pulse wave velocity in middle-aged individuals and with an 9.1% increase in elderly individuals (P for interaction <0.01). An independent association between 24-h ABPM and urine albumin : Creatinine ratio was only observed in the elderly subgroup. Associations between the presence of atherosclerotic plaques and components from 24-h ABPM except 24-h DBP were not modified by age (all P for interaction >0.26). Conclusion: Age enhances the associations between hemodynamic components obtained from 24-h ABPM and measures of arterial stiffness, microvascular damage, and cardiac structure, but not atherosclerosis.

KW - Ageing

KW - Ambulatory blood pressure

KW - Population cohort

KW - Target organ damage

U2 - 10.1097/HJH.0000000000001778

DO - 10.1097/HJH.0000000000001778

M3 - Journal article

VL - 36

SP - 1895

EP - 1901

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 9

ER -