Immunoglobulin deposits in peripheral nerve endings detected by skin biopsy in patients with IgM M proteins and neuropathy

V Jønsson, T S Jensen, M L Friis, H D Schrøder, B Stigsby, J Struck, E Hippe, W Trojaborg

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Immunofluorescence studies of sural nerve and skin biopsies from three patients with IgM M proteins and clinical neuropathy showed that IgM M protein was bound to the nerve myelin in two patients and by the peri- and endoneurium in one. It is suggested that immunohistochemical studies of skin biopsies provide a simple effective method of detecting immunoglobulin binding to peripheral nerves in patients suspected of having an autoimmune neuropathy. In contrast to sural nerve biopsy, skin biopsy does not cause sensory loss or pain in a denervated area and can easily be repeated.

OriginalsprogEngelsk
TidsskriftNeurology
Vol/bind37
Udgave nummer2
Sider (fra-til)303-6
Antal sider4
ISSN0028-3878
StatusUdgivet - feb. 1987

Fingeraftryk

Dyk ned i forskningsemnerne om 'Immunoglobulin deposits in peripheral nerve endings detected by skin biopsy in patients with IgM M proteins and neuropathy'. Sammen danner de et unikt fingeraftryk.

Citationsformater