Hypoxia-regulated MicroRNAs in gastroesophageal cancer

M. Winther; J. Alsner; B.S. Sørensen; C. F. Wittrup; T Tramm; L Bæksgaard; K Hofland; E. Holtved; M Nordsmark

Hypoxia-regulated MicroRNAs in gastroesophageal cancer

M. Winther, J. Alsner, B.S. Sørensen, C. F. Wittrup, T Tramm, L Bæksgaard, K Hofland, E. Holtved, M Nordsmark

KI, OUH, Forskningsenhed for Onkologi (Odense)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. Results: Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p

Originalsprog	Engelsk
Tidsskrift	Anticancer Research
Vol/bind	36
Udgave nummer	2
Sider (fra-til)	721-730
ISSN	0250-7005
Status	Udgivet - 2016

Bibliografisk note

Export Date: 22 March 2017 CODEN: ANTRD

Dokumenter og links

http://ar.iiarjournals.org/content/36/2/721.abstract?sid=fdaddca0-9804-402a-aecd-c950272ff83e

SDU link

Tjek adgangen til materialet i Syddansk Universitetsbiblioteks søgemaskine

Citationsformater

@article{c73a51f3f7bc45828d42cc05cb356456,

title = "Hypoxia-regulated MicroRNAs in gastroesophageal cancer",

abstract = "Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. Results: Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p",

author = "M. Winther and J. Alsner and B.S. S{\o}rensen and Wittrup, {C. F.} and T Tramm and L B{\ae}ksgaard and K Hofland and E. Holtved and M Nordsmark",

note = "Export Date: 22 March 2017 CODEN: ANTRD",

year = "2016",

language = "English",

volume = "36",

pages = "721--730",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "2",

}

TY - JOUR

T1 - Hypoxia-regulated MicroRNAs in gastroesophageal cancer

AU - Winther, M.

AU - Alsner, J.

AU - Sørensen, B.S.

AU - Wittrup, C. F.

AU - Tramm, T

AU - Bæksgaard, L

AU - Hofland, K

AU - Holtved, E.

AU - Nordsmark, M

N1 - Export Date: 22 March 2017 CODEN: ANTRD

PY - 2016

Y1 - 2016

N2 - Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. Results: Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p

AB - Background/aim: The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). Materials and Methods: microRNA expression changes induced by hypoxia in human GEC cell lines were measured with microarrays and validated by quantitative real-time polymerase chain reaction. Candidate HRMs were measured in pre-therapeutic tumor samples from 195 patients with GEC. Results: Expression of miR-210 was shown to be significantly induced in esophageal squamous cell carcinoma (9.26-fold, p

M3 - Journal article

SN - 0250-7005

VL - 36

SP - 721

EP - 730

JO - Anticancer Research

JF - Anticancer Research

IS - 2

ER -