In type 2 diabetes, reduced insulin-stimulated glucose disposal, primarily glycogen synthesis, is associated with defective insulin activation of glycogen synthase (GS) in skeletal muscle. Hyperglycaemia may compensate for these defects, but to what extent it involves improved insulin signalling to glycogen synthesis remains to be clarified.
Vind, B. F., Birk, J. B., Vienberg, S. G., Andersen, B., Beck-Nielsen, H., Wojtaszewski, J., & Højlund, K. (2012). Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes. Diabetologia, 55(5), 1435-45. https://doi.org/10.1007/s00125-012-2482-8