Human skeletal muscle contains no detectable guanidinoacetic acid

Sergej M Ostojic, Jelena Ostojic

Publikation: Bidrag til tidsskriftLetterForskningpeer review

58 Downloads (Pure)

Resumé

We analyzed data from previously completed trials to determine the effects of supplemental guanidinoacetic acid (GAA) on markers of muscle bioenergetics in healthy men using 1.5 T magnetic resonance spectroscopy. No detectable GAA (<0.1 μmol/L) was found in the vastus medialis muscle at baseline nor at follow-up. This implies deficient GAA availability in the human skeletal muscle, suggesting absent or negligible potential for creatine synthesis from GAA inside this tissue, even after GAA loading.

OriginalsprogEngelsk
TidsskriftApplied Physiology, Nutrition and Metabolism
Vol/bind43
Udgave nummer6
Sider (fra-til)647-649
ISSN1715-5312
DOI
StatusUdgivet - jun. 2018

Fingeraftryk

Skeletal Muscle
Muscles
Creatine
Quadriceps Muscle
Energy Metabolism

Citer dette

@article{e699902d454e41fd8a47c30aaebc2b9e,
title = "Human skeletal muscle contains no detectable guanidinoacetic acid",
abstract = "We analyzed data from previously completed trials to determine the effects of supplemental guanidinoacetic acid (GAA) on markers of muscle bioenergetics in healthy men using 1.5 T magnetic resonance spectroscopy. No detectable GAA (<0.1 μmol/L) was found in the vastus medialis muscle at baseline nor at follow-up. This implies deficient GAA availability in the human skeletal muscle, suggesting absent or negligible potential for creatine synthesis from GAA inside this tissue, even after GAA loading.",
keywords = "Guanidinoacetic acid, Magnetic resonance spectroscopy, Vastus medialis",
author = "Ostojic, {Sergej M} and Jelena Ostojic",
year = "2018",
month = "6",
doi = "10.1139/apnm-2017-0873",
language = "English",
volume = "43",
pages = "647--649",
journal = "Applied Physiology, Nutrition and Metabolism",
issn = "1715-5312",
publisher = "Canadian Science Publishing",
number = "6",

}

Human skeletal muscle contains no detectable guanidinoacetic acid. / Ostojic, Sergej M; Ostojic, Jelena.

I: Applied Physiology, Nutrition and Metabolism, Bind 43, Nr. 6, 06.2018, s. 647-649.

Publikation: Bidrag til tidsskriftLetterForskningpeer review

TY - JOUR

T1 - Human skeletal muscle contains no detectable guanidinoacetic acid

AU - Ostojic, Sergej M

AU - Ostojic, Jelena

PY - 2018/6

Y1 - 2018/6

N2 - We analyzed data from previously completed trials to determine the effects of supplemental guanidinoacetic acid (GAA) on markers of muscle bioenergetics in healthy men using 1.5 T magnetic resonance spectroscopy. No detectable GAA (<0.1 μmol/L) was found in the vastus medialis muscle at baseline nor at follow-up. This implies deficient GAA availability in the human skeletal muscle, suggesting absent or negligible potential for creatine synthesis from GAA inside this tissue, even after GAA loading.

AB - We analyzed data from previously completed trials to determine the effects of supplemental guanidinoacetic acid (GAA) on markers of muscle bioenergetics in healthy men using 1.5 T magnetic resonance spectroscopy. No detectable GAA (<0.1 μmol/L) was found in the vastus medialis muscle at baseline nor at follow-up. This implies deficient GAA availability in the human skeletal muscle, suggesting absent or negligible potential for creatine synthesis from GAA inside this tissue, even after GAA loading.

KW - Guanidinoacetic acid

KW - Magnetic resonance spectroscopy

KW - Vastus medialis

U2 - 10.1139/apnm-2017-0873

DO - 10.1139/apnm-2017-0873

M3 - Letter

VL - 43

SP - 647

EP - 649

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

SN - 1715-5312

IS - 6

ER -