Human intestinal P-glycoprotein activity estimated by the model substrate digoxin

U L Larsen, L Hyldahl Olesen, Charlotte Guldborg Nyvold, J Eriksen, P Jakobsen, M Østergaard, Herman Autrup, Vibeke Andersen

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Abstrakt

P-glycoprotein (Pgp) plays a part in the intestinal uptake of xenobiotics and has been associated with susceptibility to ulcerative colitis. The aim of this study was to examine Pgp activity in relation to age, gender, medical treatment (rifampicin or ketoconazole) and the multidrug resistance (MDR1) gene single nucleotide polymorphisms (SNPs) G2677T and C3435T using the model drug digoxin.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical & Laboratory Investigation
Vol/bind67
Udgave nummer2
Sider (fra-til)123-34
ISSN0036-5513
DOI
StatusUdgivet - 2007

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