Human CD56bright NK Cells: An Update

Tatiana Michel, Aurélie Poli, Angelica Cuapio, Benjamin Briquemont, Gilles Iserentant, Markus Ollert, Jacques Zimmer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

Human NK cells can be subdivided into various subsets based on the relative expression of CD16 and CD56. In particular, CD56(bright)CD16(-/dim) NK cells are the focus of interest. They are considered efficient cytokine producers endowed with immunoregulatory properties, but they can also become cytotoxic upon appropriate activation. These cells were shown to play a role in different disease states, such as cancer, autoimmunity, neuroinflammation, and infection. Although their phenotype and functional properties are well known and have been extensively studied, their lineage relationship with other NK cell subsets is not fully defined, nor is their precise hematopoietic origin. In this article, we summarize recent studies about CD56(bright) NK cells in health and disease and briefly discuss the current controversies surrounding them.

OriginalsprogEngelsk
TidsskriftJournal of Immunology
Vol/bind196
Udgave nummer7
Sider (fra-til)2923-2931
ISSN0022-1767
DOI
StatusUdgivet - 2016

Fingeraftryk

Autoimmunity
Health
Neoplasms

Citer dette

Michel, T., Poli, A., Cuapio, A., Briquemont, B., Iserentant, G., Ollert, M., & Zimmer, J. (2016). Human CD56bright NK Cells: An Update. Journal of Immunology, 196(7), 2923-2931. https://doi.org/10.4049/jimmunol.1502570
Michel, Tatiana ; Poli, Aurélie ; Cuapio, Angelica ; Briquemont, Benjamin ; Iserentant, Gilles ; Ollert, Markus ; Zimmer, Jacques. / Human CD56bright NK Cells : An Update. I: Journal of Immunology. 2016 ; Bind 196, Nr. 7. s. 2923-2931.
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abstract = "Human NK cells can be subdivided into various subsets based on the relative expression of CD16 and CD56. In particular, CD56(bright)CD16(-/dim) NK cells are the focus of interest. They are considered efficient cytokine producers endowed with immunoregulatory properties, but they can also become cytotoxic upon appropriate activation. These cells were shown to play a role in different disease states, such as cancer, autoimmunity, neuroinflammation, and infection. Although their phenotype and functional properties are well known and have been extensively studied, their lineage relationship with other NK cell subsets is not fully defined, nor is their precise hematopoietic origin. In this article, we summarize recent studies about CD56(bright) NK cells in health and disease and briefly discuss the current controversies surrounding them.",
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Michel, T, Poli, A, Cuapio, A, Briquemont, B, Iserentant, G, Ollert, M & Zimmer, J 2016, 'Human CD56bright NK Cells: An Update', Journal of Immunology, bind 196, nr. 7, s. 2923-2931. https://doi.org/10.4049/jimmunol.1502570

Human CD56bright NK Cells : An Update. / Michel, Tatiana; Poli, Aurélie; Cuapio, Angelica; Briquemont, Benjamin; Iserentant, Gilles; Ollert, Markus; Zimmer, Jacques.

I: Journal of Immunology, Bind 196, Nr. 7, 2016, s. 2923-2931.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Human CD56bright NK Cells

T2 - An Update

AU - Michel, Tatiana

AU - Poli, Aurélie

AU - Cuapio, Angelica

AU - Briquemont, Benjamin

AU - Iserentant, Gilles

AU - Ollert, Markus

AU - Zimmer, Jacques

N1 - Copyright © 2016 by The American Association of Immunologists, Inc.

PY - 2016

Y1 - 2016

N2 - Human NK cells can be subdivided into various subsets based on the relative expression of CD16 and CD56. In particular, CD56(bright)CD16(-/dim) NK cells are the focus of interest. They are considered efficient cytokine producers endowed with immunoregulatory properties, but they can also become cytotoxic upon appropriate activation. These cells were shown to play a role in different disease states, such as cancer, autoimmunity, neuroinflammation, and infection. Although their phenotype and functional properties are well known and have been extensively studied, their lineage relationship with other NK cell subsets is not fully defined, nor is their precise hematopoietic origin. In this article, we summarize recent studies about CD56(bright) NK cells in health and disease and briefly discuss the current controversies surrounding them.

AB - Human NK cells can be subdivided into various subsets based on the relative expression of CD16 and CD56. In particular, CD56(bright)CD16(-/dim) NK cells are the focus of interest. They are considered efficient cytokine producers endowed with immunoregulatory properties, but they can also become cytotoxic upon appropriate activation. These cells were shown to play a role in different disease states, such as cancer, autoimmunity, neuroinflammation, and infection. Although their phenotype and functional properties are well known and have been extensively studied, their lineage relationship with other NK cell subsets is not fully defined, nor is their precise hematopoietic origin. In this article, we summarize recent studies about CD56(bright) NK cells in health and disease and briefly discuss the current controversies surrounding them.

KW - Animals

KW - Antigens, CD56

KW - Cell Differentiation

KW - Cytotoxicity, Immunologic

KW - Humans

KW - Immunity, Innate

KW - Immunotherapy

KW - Killer Cells, Natural

KW - Lymphocyte Subsets

KW - Phenotype

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.4049/jimmunol.1502570

DO - 10.4049/jimmunol.1502570

M3 - Journal article

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VL - 196

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SN - 0022-1767

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Michel T, Poli A, Cuapio A, Briquemont B, Iserentant G, Ollert M et al. Human CD56bright NK Cells: An Update. Journal of Immunology. 2016;196(7):2923-2931. https://doi.org/10.4049/jimmunol.1502570