How are children who are delayed in the Childhood Vaccination Programme vaccinated: A nationwide register-based cohort study of Danish children aged 15–24 months and semi-structured interviews with vaccination providers

Kenneth B. Pedersen, Marie E. Holck, Aksel K.G. Jensen, Camilla H. Suppli, Christine S. Benn, Tyra G. Krause, Signe Sørup*

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Resumé

Aims: Delay of childhood vaccinations is common and influences efforts to reduce targeted diseases. In Denmark, the diphtheria, tetanus, pertussis, polio and Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine is recommended at ages 3, 5 and 12 months and the first measles–mumps–rubella vaccine (MMR-1) at 15 months. Following guidelines, children delayed at age 15 months should receive MMR-1 and DTaP-IPV-Hib-3 simultaneously, unless DTaP-IPV-Hib-2 was received less than 6 months ago, when MMR-1 alone is recommended. We studied compliance with these guidelines and the reasons for non-compliance with a focus on vaccination providers. Methods: We used a nationwide register-based cohort study of children born in Denmark between January 2000 and June 2013, who were lacking MMR-1 and DTaP-IPV-Hib-3 at age 15 months and were followed to 24 months. We also performed semi-structured telephone interviews with vaccination providers. Results: The study consisted of 156,921 children (18% of the children born in the period). Among the 40,060 children who had received DTaP-IPV-Hib-2 less than 6 months ago, 37,892 (95%) received MMR-1 alone. Among the 88,469 children who had received DTaP-IPV-Hib-2 more than 6 months ago, 6334 (7%) received DTaP-IPV-Hib-3 and MMR-1 simultaneously. The interviews indicated that some vaccination providers are reluctant to give multiple vaccinations at the same visit and some have a preference of following the usual sequence in the programme. Conclusions: Vaccination providers generally complied with the recommended minimum 6 months’ interval between DTaP-IPV-Hib-2 and DTaP-IPV-Hib-3. Conversely, there was a low compliance with the recommendation to administer DTaP-IPV-Hib-3 and MMR-1 simultaneously. More efforts are needed to ensure timely vaccination.

OriginalsprogEngelsk
BogserieScandinavian Journal of Public Health
Vol/bind48
Udgave nummer1
Sider (fra-til)96-105
ISSN1403-4948
DOI
StatusUdgivet - feb. 2020

Fingeraftryk

Haemophilus influenzae type b
Cohort Studies
Interviews
Denmark
Measles-Mumps-Rubella Vaccine
Guidelines
Diphtheria
Whooping Cough

Citer dette

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title = "How are children who are delayed in the Childhood Vaccination Programme vaccinated: A nationwide register-based cohort study of Danish children aged 15–24 months and semi-structured interviews with vaccination providers",
abstract = "Aims: Delay of childhood vaccinations is common and influences efforts to reduce targeted diseases. In Denmark, the diphtheria, tetanus, pertussis, polio and Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine is recommended at ages 3, 5 and 12 months and the first measles–mumps–rubella vaccine (MMR-1) at 15 months. Following guidelines, children delayed at age 15 months should receive MMR-1 and DTaP-IPV-Hib-3 simultaneously, unless DTaP-IPV-Hib-2 was received less than 6 months ago, when MMR-1 alone is recommended. We studied compliance with these guidelines and the reasons for non-compliance with a focus on vaccination providers. Methods: We used a nationwide register-based cohort study of children born in Denmark between January 2000 and June 2013, who were lacking MMR-1 and DTaP-IPV-Hib-3 at age 15 months and were followed to 24 months. We also performed semi-structured telephone interviews with vaccination providers. Results: The study consisted of 156,921 children (18{\%} of the children born in the period). Among the 40,060 children who had received DTaP-IPV-Hib-2 less than 6 months ago, 37,892 (95{\%}) received MMR-1 alone. Among the 88,469 children who had received DTaP-IPV-Hib-2 more than 6 months ago, 6334 (7{\%}) received DTaP-IPV-Hib-3 and MMR-1 simultaneously. The interviews indicated that some vaccination providers are reluctant to give multiple vaccinations at the same visit and some have a preference of following the usual sequence in the programme. Conclusions: Vaccination providers generally complied with the recommended minimum 6 months’ interval between DTaP-IPV-Hib-2 and DTaP-IPV-Hib-3. Conversely, there was a low compliance with the recommendation to administer DTaP-IPV-Hib-3 and MMR-1 simultaneously. More efforts are needed to ensure timely vaccination.",
keywords = "delayed vaccinations, Diphtheria–tetanus–acellular pertussis–polio–Haemophilus influenzae type b vaccine, measles–mumps–rubella vaccine, missed vaccination opportunities, vaccination coverage",
author = "Pedersen, {Kenneth B.} and Holck, {Marie E.} and Jensen, {Aksel K.G.} and Suppli, {Camilla H.} and Benn, {Christine S.} and Krause, {Tyra G.} and Signe S{\o}rup",
year = "2020",
month = "2",
doi = "10.1177/1403494818786146",
language = "English",
volume = "48",
pages = "96--105",
journal = "Scandinavian Journal of Public Health. Supplement",
issn = "1403-4956",
publisher = "SAGE Publications",
number = "1",

}

How are children who are delayed in the Childhood Vaccination Programme vaccinated : A nationwide register-based cohort study of Danish children aged 15–24 months and semi-structured interviews with vaccination providers. / Pedersen, Kenneth B.; Holck, Marie E.; Jensen, Aksel K.G.; Suppli, Camilla H.; Benn, Christine S.; Krause, Tyra G.; Sørup, Signe.

I: Scandinavian Journal of Public Health, Bind 48, Nr. 1, 02.2020, s. 96-105.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - How are children who are delayed in the Childhood Vaccination Programme vaccinated

T2 - A nationwide register-based cohort study of Danish children aged 15–24 months and semi-structured interviews with vaccination providers

AU - Pedersen, Kenneth B.

AU - Holck, Marie E.

AU - Jensen, Aksel K.G.

AU - Suppli, Camilla H.

AU - Benn, Christine S.

AU - Krause, Tyra G.

AU - Sørup, Signe

PY - 2020/2

Y1 - 2020/2

N2 - Aims: Delay of childhood vaccinations is common and influences efforts to reduce targeted diseases. In Denmark, the diphtheria, tetanus, pertussis, polio and Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine is recommended at ages 3, 5 and 12 months and the first measles–mumps–rubella vaccine (MMR-1) at 15 months. Following guidelines, children delayed at age 15 months should receive MMR-1 and DTaP-IPV-Hib-3 simultaneously, unless DTaP-IPV-Hib-2 was received less than 6 months ago, when MMR-1 alone is recommended. We studied compliance with these guidelines and the reasons for non-compliance with a focus on vaccination providers. Methods: We used a nationwide register-based cohort study of children born in Denmark between January 2000 and June 2013, who were lacking MMR-1 and DTaP-IPV-Hib-3 at age 15 months and were followed to 24 months. We also performed semi-structured telephone interviews with vaccination providers. Results: The study consisted of 156,921 children (18% of the children born in the period). Among the 40,060 children who had received DTaP-IPV-Hib-2 less than 6 months ago, 37,892 (95%) received MMR-1 alone. Among the 88,469 children who had received DTaP-IPV-Hib-2 more than 6 months ago, 6334 (7%) received DTaP-IPV-Hib-3 and MMR-1 simultaneously. The interviews indicated that some vaccination providers are reluctant to give multiple vaccinations at the same visit and some have a preference of following the usual sequence in the programme. Conclusions: Vaccination providers generally complied with the recommended minimum 6 months’ interval between DTaP-IPV-Hib-2 and DTaP-IPV-Hib-3. Conversely, there was a low compliance with the recommendation to administer DTaP-IPV-Hib-3 and MMR-1 simultaneously. More efforts are needed to ensure timely vaccination.

AB - Aims: Delay of childhood vaccinations is common and influences efforts to reduce targeted diseases. In Denmark, the diphtheria, tetanus, pertussis, polio and Haemophilus influenzae type b (DTaP-IPV-Hib) vaccine is recommended at ages 3, 5 and 12 months and the first measles–mumps–rubella vaccine (MMR-1) at 15 months. Following guidelines, children delayed at age 15 months should receive MMR-1 and DTaP-IPV-Hib-3 simultaneously, unless DTaP-IPV-Hib-2 was received less than 6 months ago, when MMR-1 alone is recommended. We studied compliance with these guidelines and the reasons for non-compliance with a focus on vaccination providers. Methods: We used a nationwide register-based cohort study of children born in Denmark between January 2000 and June 2013, who were lacking MMR-1 and DTaP-IPV-Hib-3 at age 15 months and were followed to 24 months. We also performed semi-structured telephone interviews with vaccination providers. Results: The study consisted of 156,921 children (18% of the children born in the period). Among the 40,060 children who had received DTaP-IPV-Hib-2 less than 6 months ago, 37,892 (95%) received MMR-1 alone. Among the 88,469 children who had received DTaP-IPV-Hib-2 more than 6 months ago, 6334 (7%) received DTaP-IPV-Hib-3 and MMR-1 simultaneously. The interviews indicated that some vaccination providers are reluctant to give multiple vaccinations at the same visit and some have a preference of following the usual sequence in the programme. Conclusions: Vaccination providers generally complied with the recommended minimum 6 months’ interval between DTaP-IPV-Hib-2 and DTaP-IPV-Hib-3. Conversely, there was a low compliance with the recommendation to administer DTaP-IPV-Hib-3 and MMR-1 simultaneously. More efforts are needed to ensure timely vaccination.

KW - delayed vaccinations

KW - Diphtheria–tetanus–acellular pertussis–polio–Haemophilus influenzae type b vaccine

KW - measles–mumps–rubella vaccine

KW - missed vaccination opportunities

KW - vaccination coverage

U2 - 10.1177/1403494818786146

DO - 10.1177/1403494818786146

M3 - Journal article

C2 - 30024308

AN - SCOPUS:85050202975

VL - 48

SP - 96

EP - 105

JO - Scandinavian Journal of Public Health. Supplement

JF - Scandinavian Journal of Public Health. Supplement

SN - 1403-4956

IS - 1

ER -