HIV-associated neurodegeneration and neuroimmunity

multivoxel MR spectroscopy study in drug-naïve and treated patients

Jasmina Boban, Dusko Kozic, Vesna Turkulov, Jelena Ostojic, Robert Semnic, Dajana Lendak, Snezana Brkic

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVES: The aim of this study was to test neurobiochemical changes in normal appearing brain tissue in HIV+ patients receiving and not receiving combined antiretroviral therapy (cART) and healthy controls, using multivoxel MR spectroscopy (mvMRS).

METHODS: We performed long- and short-echo 3D mvMRS in 110 neuroasymptomatic subjects (32 HIV+ subjects on cART, 28 HIV+ therapy-naïve subjects and 50 healthy controls) on a 3T MR scanner, targeting frontal and parietal supracallosal subcortical and deep white matter and cingulate gyrus (NAA/Cr, Cho/Cr and mI/Cr ratios were analysed). The statistical value was set at p < 0.05.

RESULTS: Considering differences between HIV-infected and healthy subjects, there was a significant decrease in the NAA/Cr ratio in HIV+ subjects in all observed locations, an increase in mI/Cr levels in the anterior cingulate gyrus (ACG), and no significant differences in Cho/Cr ratios, except in ACG, where the increase showed trending towards significance in HIV+ patients. There were no significant differences between HIV+ patients on and without cART in all three ratios.

CONCLUSION: Neuronal loss and dysfunction affects the whole brain volume in HIV-infected patients. Unfortunately, cART appears to be ineffective in halting accelerated neurodegenerative process induced by HIV but is partially effective in preventing glial proliferation.

KEY POINTS: • This is the first multivoxel human brain 3T MRS study in HIV. • All observed areas of the brain are affected by neurodegenerative process. • Cingulate gyrus and subcortical white matter are most vulnerable to HIV-induced neurodegeneration. • cART is effective in control of inflammation but ineffective in preventing neurodegeneration.

OriginalsprogEngelsk
TidsskriftEuropean Radiology
Vol/bind27
Udgave nummer10
Sider (fra-til)4218-4236
ISSN0938-7994
DOI
StatusUdgivet - 2017
Udgivet eksterntJa

Fingeraftryk

HIV
Pharmaceutical Preparations
Gyrus Cinguli
Neuroglia

Citer dette

Boban, Jasmina ; Kozic, Dusko ; Turkulov, Vesna ; Ostojic, Jelena ; Semnic, Robert ; Lendak, Dajana ; Brkic, Snezana. / HIV-associated neurodegeneration and neuroimmunity : multivoxel MR spectroscopy study in drug-naïve and treated patients. I: European Radiology. 2017 ; Bind 27, Nr. 10. s. 4218-4236.
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abstract = "OBJECTIVES: The aim of this study was to test neurobiochemical changes in normal appearing brain tissue in HIV+ patients receiving and not receiving combined antiretroviral therapy (cART) and healthy controls, using multivoxel MR spectroscopy (mvMRS).METHODS: We performed long- and short-echo 3D mvMRS in 110 neuroasymptomatic subjects (32 HIV+ subjects on cART, 28 HIV+ therapy-na{\"i}ve subjects and 50 healthy controls) on a 3T MR scanner, targeting frontal and parietal supracallosal subcortical and deep white matter and cingulate gyrus (NAA/Cr, Cho/Cr and mI/Cr ratios were analysed). The statistical value was set at p < 0.05.RESULTS: Considering differences between HIV-infected and healthy subjects, there was a significant decrease in the NAA/Cr ratio in HIV+ subjects in all observed locations, an increase in mI/Cr levels in the anterior cingulate gyrus (ACG), and no significant differences in Cho/Cr ratios, except in ACG, where the increase showed trending towards significance in HIV+ patients. There were no significant differences between HIV+ patients on and without cART in all three ratios.CONCLUSION: Neuronal loss and dysfunction affects the whole brain volume in HIV-infected patients. Unfortunately, cART appears to be ineffective in halting accelerated neurodegenerative process induced by HIV but is partially effective in preventing glial proliferation.KEY POINTS: • This is the first multivoxel human brain 3T MRS study in HIV. • All observed areas of the brain are affected by neurodegenerative process. • Cingulate gyrus and subcortical white matter are most vulnerable to HIV-induced neurodegeneration. • cART is effective in control of inflammation but ineffective in preventing neurodegeneration.",
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author = "Jasmina Boban and Dusko Kozic and Vesna Turkulov and Jelena Ostojic and Robert Semnic and Dajana Lendak and Snezana Brkic",
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HIV-associated neurodegeneration and neuroimmunity : multivoxel MR spectroscopy study in drug-naïve and treated patients. / Boban, Jasmina; Kozic, Dusko; Turkulov, Vesna; Ostojic, Jelena; Semnic, Robert; Lendak, Dajana; Brkic, Snezana.

I: European Radiology, Bind 27, Nr. 10, 2017, s. 4218-4236.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - HIV-associated neurodegeneration and neuroimmunity

T2 - multivoxel MR spectroscopy study in drug-naïve and treated patients

AU - Boban, Jasmina

AU - Kozic, Dusko

AU - Turkulov, Vesna

AU - Ostojic, Jelena

AU - Semnic, Robert

AU - Lendak, Dajana

AU - Brkic, Snezana

PY - 2017

Y1 - 2017

N2 - OBJECTIVES: The aim of this study was to test neurobiochemical changes in normal appearing brain tissue in HIV+ patients receiving and not receiving combined antiretroviral therapy (cART) and healthy controls, using multivoxel MR spectroscopy (mvMRS).METHODS: We performed long- and short-echo 3D mvMRS in 110 neuroasymptomatic subjects (32 HIV+ subjects on cART, 28 HIV+ therapy-naïve subjects and 50 healthy controls) on a 3T MR scanner, targeting frontal and parietal supracallosal subcortical and deep white matter and cingulate gyrus (NAA/Cr, Cho/Cr and mI/Cr ratios were analysed). The statistical value was set at p < 0.05.RESULTS: Considering differences between HIV-infected and healthy subjects, there was a significant decrease in the NAA/Cr ratio in HIV+ subjects in all observed locations, an increase in mI/Cr levels in the anterior cingulate gyrus (ACG), and no significant differences in Cho/Cr ratios, except in ACG, where the increase showed trending towards significance in HIV+ patients. There were no significant differences between HIV+ patients on and without cART in all three ratios.CONCLUSION: Neuronal loss and dysfunction affects the whole brain volume in HIV-infected patients. Unfortunately, cART appears to be ineffective in halting accelerated neurodegenerative process induced by HIV but is partially effective in preventing glial proliferation.KEY POINTS: • This is the first multivoxel human brain 3T MRS study in HIV. • All observed areas of the brain are affected by neurodegenerative process. • Cingulate gyrus and subcortical white matter are most vulnerable to HIV-induced neurodegeneration. • cART is effective in control of inflammation but ineffective in preventing neurodegeneration.

AB - OBJECTIVES: The aim of this study was to test neurobiochemical changes in normal appearing brain tissue in HIV+ patients receiving and not receiving combined antiretroviral therapy (cART) and healthy controls, using multivoxel MR spectroscopy (mvMRS).METHODS: We performed long- and short-echo 3D mvMRS in 110 neuroasymptomatic subjects (32 HIV+ subjects on cART, 28 HIV+ therapy-naïve subjects and 50 healthy controls) on a 3T MR scanner, targeting frontal and parietal supracallosal subcortical and deep white matter and cingulate gyrus (NAA/Cr, Cho/Cr and mI/Cr ratios were analysed). The statistical value was set at p < 0.05.RESULTS: Considering differences between HIV-infected and healthy subjects, there was a significant decrease in the NAA/Cr ratio in HIV+ subjects in all observed locations, an increase in mI/Cr levels in the anterior cingulate gyrus (ACG), and no significant differences in Cho/Cr ratios, except in ACG, where the increase showed trending towards significance in HIV+ patients. There were no significant differences between HIV+ patients on and without cART in all three ratios.CONCLUSION: Neuronal loss and dysfunction affects the whole brain volume in HIV-infected patients. Unfortunately, cART appears to be ineffective in halting accelerated neurodegenerative process induced by HIV but is partially effective in preventing glial proliferation.KEY POINTS: • This is the first multivoxel human brain 3T MRS study in HIV. • All observed areas of the brain are affected by neurodegenerative process. • Cingulate gyrus and subcortical white matter are most vulnerable to HIV-induced neurodegeneration. • cART is effective in control of inflammation but ineffective in preventing neurodegeneration.

KW - AIDS Dementia Complex/diagnostic imaging

KW - Adult

KW - Aspartic Acid/analysis

KW - Biomarkers/analysis

KW - Brain/diagnostic imaging

KW - Case-Control Studies

KW - Choline/analysis

KW - Creatine/analysis

KW - Female

KW - HIV Infections/complications

KW - Humans

KW - Magnetic Resonance Spectroscopy/methods

KW - Male

KW - Middle Aged

KW - Neurodegenerative Diseases/diagnostic imaging

KW - Retrospective Studies

KW - White Matter/diagnostic imaging

KW - Young Adult

U2 - 10.1007/s00330-017-4772-5

DO - 10.1007/s00330-017-4772-5

M3 - Journal article

VL - 27

SP - 4218

EP - 4236

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 10

ER -