Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy

3D multivoxel spectroscopy study

Aleksandar J Ristić, Jelena Ostojić, Duško Kozić, Nikola M Vojvodić, Ljubica M Popović, Slavko Janković, Vladimir Baščarević, Dragoslav V Sokić

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

PURPOSE: To investigate the metabolic differences in hippocampi of patients with juvenile myoclonic epilepsy (JME) and healthy controls using magnetic resonance spectroscopy (MRS).

METHODS: A 3D multivoxel SE 135 MRS study on 1.5 T scanner of both hippocampi was performed in 17 patients with JME and normal brain MRI and in 19 age and sex matched controls. Three dominant signals were measured: Choline (Cho), Creatine (tCr) and N-Acetylaspartate (NAA) and expressed as ratios of Cho:tCr, NAA:tCr, NAA:Cho and NAA:(Cho+tCr). Metabolite ratios in head, body and tail of each hippocampus in the JME group of patients were compared with ratios from corresponding structures in the control group.

RESULTS: We found a significant difference in metabolite ratios of both hippocampi between the JME and the control groups. We detected significant differences of Cho:tCr in the head, NAA:tCr in the head, body and tail, NAA:Cho and NAA:(Cho+tCr) in the body and tail of the left hippocampus, and NAA:Cho and NAA:(Cho+tCr) in the body and tail of the right hippocampus.

DISCUSSION: Although not previously recognized as a part of the epileptogenic network, our results suggest that the hippocampus, well recognized as a key player in focal epilepsies, may have a certain role in the pathogenesis of JME.

OriginalsprogEngelsk
TidsskriftJournal of the Neurological Sciences
Vol/bind305
Udgave nummer1-2
Sider (fra-til)139-42
Antal sider4
ISSN0022-510X
DOI
StatusUdgivet - 15. jun. 2011

Fingeraftryk

Juvenile Myoclonic Epilepsy
Choline
N-acetylaspartate
Control Groups
Creatine

Citer dette

Ristić, A. J., Ostojić, J., Kozić, D., Vojvodić, N. M., Popović, L. M., Janković, S., ... Sokić, D. V. (2011). Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study. Journal of the Neurological Sciences, 305(1-2), 139-42. https://doi.org/10.1016/j.jns.2010.12.022
Ristić, Aleksandar J ; Ostojić, Jelena ; Kozić, Duško ; Vojvodić, Nikola M ; Popović, Ljubica M ; Janković, Slavko ; Baščarević, Vladimir ; Sokić, Dragoslav V. / Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy : 3D multivoxel spectroscopy study. I: Journal of the Neurological Sciences. 2011 ; Bind 305, Nr. 1-2. s. 139-42.
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abstract = "PURPOSE: To investigate the metabolic differences in hippocampi of patients with juvenile myoclonic epilepsy (JME) and healthy controls using magnetic resonance spectroscopy (MRS).METHODS: A 3D multivoxel SE 135 MRS study on 1.5 T scanner of both hippocampi was performed in 17 patients with JME and normal brain MRI and in 19 age and sex matched controls. Three dominant signals were measured: Choline (Cho), Creatine (tCr) and N-Acetylaspartate (NAA) and expressed as ratios of Cho:tCr, NAA:tCr, NAA:Cho and NAA:(Cho+tCr). Metabolite ratios in head, body and tail of each hippocampus in the JME group of patients were compared with ratios from corresponding structures in the control group.RESULTS: We found a significant difference in metabolite ratios of both hippocampi between the JME and the control groups. We detected significant differences of Cho:tCr in the head, NAA:tCr in the head, body and tail, NAA:Cho and NAA:(Cho+tCr) in the body and tail of the left hippocampus, and NAA:Cho and NAA:(Cho+tCr) in the body and tail of the right hippocampus.DISCUSSION: Although not previously recognized as a part of the epileptogenic network, our results suggest that the hippocampus, well recognized as a key player in focal epilepsies, may have a certain role in the pathogenesis of JME.",
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Ristić, AJ, Ostojić, J, Kozić, D, Vojvodić, NM, Popović, LM, Janković, S, Baščarević, V & Sokić, DV 2011, 'Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy: 3D multivoxel spectroscopy study', Journal of the Neurological Sciences, bind 305, nr. 1-2, s. 139-42. https://doi.org/10.1016/j.jns.2010.12.022

Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy : 3D multivoxel spectroscopy study. / Ristić, Aleksandar J; Ostojić, Jelena; Kozić, Duško; Vojvodić, Nikola M; Popović, Ljubica M; Janković, Slavko; Baščarević, Vladimir; Sokić, Dragoslav V.

I: Journal of the Neurological Sciences, Bind 305, Nr. 1-2, 15.06.2011, s. 139-42.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Hippocampal metabolic dysfunction in juvenile myoclonic epilepsy

T2 - 3D multivoxel spectroscopy study

AU - Ristić, Aleksandar J

AU - Ostojić, Jelena

AU - Kozić, Duško

AU - Vojvodić, Nikola M

AU - Popović, Ljubica M

AU - Janković, Slavko

AU - Baščarević, Vladimir

AU - Sokić, Dragoslav V

N1 - Copyright © 2010. Published by Elsevier B.V.

PY - 2011/6/15

Y1 - 2011/6/15

N2 - PURPOSE: To investigate the metabolic differences in hippocampi of patients with juvenile myoclonic epilepsy (JME) and healthy controls using magnetic resonance spectroscopy (MRS).METHODS: A 3D multivoxel SE 135 MRS study on 1.5 T scanner of both hippocampi was performed in 17 patients with JME and normal brain MRI and in 19 age and sex matched controls. Three dominant signals were measured: Choline (Cho), Creatine (tCr) and N-Acetylaspartate (NAA) and expressed as ratios of Cho:tCr, NAA:tCr, NAA:Cho and NAA:(Cho+tCr). Metabolite ratios in head, body and tail of each hippocampus in the JME group of patients were compared with ratios from corresponding structures in the control group.RESULTS: We found a significant difference in metabolite ratios of both hippocampi between the JME and the control groups. We detected significant differences of Cho:tCr in the head, NAA:tCr in the head, body and tail, NAA:Cho and NAA:(Cho+tCr) in the body and tail of the left hippocampus, and NAA:Cho and NAA:(Cho+tCr) in the body and tail of the right hippocampus.DISCUSSION: Although not previously recognized as a part of the epileptogenic network, our results suggest that the hippocampus, well recognized as a key player in focal epilepsies, may have a certain role in the pathogenesis of JME.

AB - PURPOSE: To investigate the metabolic differences in hippocampi of patients with juvenile myoclonic epilepsy (JME) and healthy controls using magnetic resonance spectroscopy (MRS).METHODS: A 3D multivoxel SE 135 MRS study on 1.5 T scanner of both hippocampi was performed in 17 patients with JME and normal brain MRI and in 19 age and sex matched controls. Three dominant signals were measured: Choline (Cho), Creatine (tCr) and N-Acetylaspartate (NAA) and expressed as ratios of Cho:tCr, NAA:tCr, NAA:Cho and NAA:(Cho+tCr). Metabolite ratios in head, body and tail of each hippocampus in the JME group of patients were compared with ratios from corresponding structures in the control group.RESULTS: We found a significant difference in metabolite ratios of both hippocampi between the JME and the control groups. We detected significant differences of Cho:tCr in the head, NAA:tCr in the head, body and tail, NAA:Cho and NAA:(Cho+tCr) in the body and tail of the left hippocampus, and NAA:Cho and NAA:(Cho+tCr) in the body and tail of the right hippocampus.DISCUSSION: Although not previously recognized as a part of the epileptogenic network, our results suggest that the hippocampus, well recognized as a key player in focal epilepsies, may have a certain role in the pathogenesis of JME.

KW - Adolescent

KW - Adult

KW - Aspartic Acid/analogs & derivatives

KW - Biomarkers/metabolism

KW - Choline/metabolism

KW - Creatine/metabolism

KW - Female

KW - Hippocampus/metabolism

KW - Humans

KW - Imaging, Three-Dimensional/methods

KW - Magnetic Resonance Spectroscopy/methods

KW - Male

KW - Middle Aged

KW - Myoclonic Epilepsy, Juvenile/diagnosis

KW - Nerve Net/metabolism

KW - Young Adult

U2 - 10.1016/j.jns.2010.12.022

DO - 10.1016/j.jns.2010.12.022

M3 - Journal article

VL - 305

SP - 139

EP - 142

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -