Highly Sensitive Troponin T in Patients with Acute Ischemic Stroke

J K Jensen, T Ueland, P Aukrust, L Antonsen, S R Kristensen, J L Januzzi, Jan Ravkilde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. Methods: Highly sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all-cause and cardiovascular mortality end-points. Results: A total of 33.7% of the patients had hsTnT levels >14 ng/l following admission. Patients with increased hsTnT were older, had decreased hemoglobin levels and increased creatinine, NT-proBNP and CRP levels. hsTnT concentrations at admission were significantly higher in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality. Conclusion: Elevated levels of hsTnT are frequently present in patients with acute ischemic stroke previously tested normal with a fourth-generation TnT assay. hsTnT did not provide additional prognostic information in these subjects.
OriginalsprogEngelsk
TidsskriftEuropean Neurology
Vol/bind68
Udgave nummer5
Sider (fra-til)287-293
Antal sider7
ISSN0014-3022
DOI
StatusUdgivet - 2012

Fingeraftryk

Troponin T
Acute Coronary Syndrome
Survivors
Creatinine

Citer dette

Jensen, J. K., Ueland, T., Aukrust, P., Antonsen, L., Kristensen, S. R., Januzzi, J. L., & Ravkilde, J. (2012). Highly Sensitive Troponin T in Patients with Acute Ischemic Stroke. European Neurology, 68(5), 287-293. https://doi.org/10.1159/000341340
Jensen, J K ; Ueland, T ; Aukrust, P ; Antonsen, L ; Kristensen, S R ; Januzzi, J L ; Ravkilde, Jan. / Highly Sensitive Troponin T in Patients with Acute Ischemic Stroke. I: European Neurology. 2012 ; Bind 68, Nr. 5. s. 287-293.
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title = "Highly Sensitive Troponin T in Patients with Acute Ischemic Stroke",
abstract = "Background: Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. Methods: Highly sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all-cause and cardiovascular mortality end-points. Results: A total of 33.7{\%} of the patients had hsTnT levels >14 ng/l following admission. Patients with increased hsTnT were older, had decreased hemoglobin levels and increased creatinine, NT-proBNP and CRP levels. hsTnT concentrations at admission were significantly higher in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality. Conclusion: Elevated levels of hsTnT are frequently present in patients with acute ischemic stroke previously tested normal with a fourth-generation TnT assay. hsTnT did not provide additional prognostic information in these subjects.",
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Jensen, JK, Ueland, T, Aukrust, P, Antonsen, L, Kristensen, SR, Januzzi, JL & Ravkilde, J 2012, 'Highly Sensitive Troponin T in Patients with Acute Ischemic Stroke', European Neurology, bind 68, nr. 5, s. 287-293. https://doi.org/10.1159/000341340

Highly Sensitive Troponin T in Patients with Acute Ischemic Stroke. / Jensen, J K; Ueland, T; Aukrust, P; Antonsen, L; Kristensen, S R; Januzzi, J L; Ravkilde, Jan.

I: European Neurology, Bind 68, Nr. 5, 2012, s. 287-293.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Highly Sensitive Troponin T in Patients with Acute Ischemic Stroke

AU - Jensen, J K

AU - Ueland, T

AU - Aukrust, P

AU - Antonsen, L

AU - Kristensen, S R

AU - Januzzi, J L

AU - Ravkilde, Jan

N1 - Copyright © 2012 S. Karger AG, Basel.

PY - 2012

Y1 - 2012

N2 - Background: Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. Methods: Highly sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all-cause and cardiovascular mortality end-points. Results: A total of 33.7% of the patients had hsTnT levels >14 ng/l following admission. Patients with increased hsTnT were older, had decreased hemoglobin levels and increased creatinine, NT-proBNP and CRP levels. hsTnT concentrations at admission were significantly higher in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality. Conclusion: Elevated levels of hsTnT are frequently present in patients with acute ischemic stroke previously tested normal with a fourth-generation TnT assay. hsTnT did not provide additional prognostic information in these subjects.

AB - Background: Newly developed troponin assays have superior diagnostic and prognostic performance in acute coronary syndrome (ACS), when compared to conventional troponin assays; however, highly sensitive troponin has not been evaluated in patients with acute ischemic stroke. Methods: Highly sensitive troponin T (hsTnT) was measured daily during the first 4 days in 193 consecutive patients with acute ischemic stroke without overt ACS or atrial fibrillation. The patients were previously tested normal with a fourth-generation TnT assay. The patients were followed for 47 months, with all-cause and cardiovascular mortality end-points. Results: A total of 33.7% of the patients had hsTnT levels >14 ng/l following admission. Patients with increased hsTnT were older, had decreased hemoglobin levels and increased creatinine, NT-proBNP and CRP levels. hsTnT concentrations at admission were significantly higher in decedents than in survivors. After adjustment for stroke severity, C-reactive protein, age, NT-proBNP and prior heart and/or renal failure, hsTnT levels were not a significant predictor of long-term all-cause or cardiovascular mortality. Conclusion: Elevated levels of hsTnT are frequently present in patients with acute ischemic stroke previously tested normal with a fourth-generation TnT assay. hsTnT did not provide additional prognostic information in these subjects.

U2 - 10.1159/000341340

DO - 10.1159/000341340

M3 - Journal article

C2 - 23051820

VL - 68

SP - 287

EP - 293

JO - European Neurology

JF - European Neurology

SN - 0014-3022

IS - 5

ER -

Jensen JK, Ueland T, Aukrust P, Antonsen L, Kristensen SR, Januzzi JL et al. Highly Sensitive Troponin T in Patients with Acute Ischemic Stroke. European Neurology. 2012;68(5):287-293. https://doi.org/10.1159/000341340