High serum coenzyme Q10, positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study

H S Pedersen, S A Mortensen, M Rohde, Y Deguchi, G Mulvad, P Bjerregaard, J C Hansen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n-6/n-3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substantial impact. From a health survey we chose the subpopulation from the most remote area, where the traditional Greenlandic diet with high intake of sea mammals and fish predominates. The mean (SD) of S-CoQ10 in males was 1.495 (0.529) nmol/ml and 1.421 (0.629) nmol/ml in females, significantly higher (p < 0.001) compared to a Danish population. In a linear multiple regression model the S-CoQ10 level is significantly positively associated with age and S-selenium in males, and S-total cholesterol in females. The high level of CoQ10 in Greenlanders probably reflects diet, since no bioaccumulation takes place, and it could probably be a substantial part of the antioxidative defense.

OriginalsprogEngelsk
TidsskriftBioFactors
Vol/bind9
Udgave nummer2-4
Sider (fra-til)319-23
Antal sider5
ISSN0951-6433
StatusUdgivet - 1999

Fingeraftryk Dyk ned i forskningsemnerne om 'High serum coenzyme Q10, positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study'. Sammen danner de et unikt fingeraftryk.

Citationsformater