High rate of benign histology in radiologically suspect renal lesions

Christina Lindkvist Pedersen, Lili Winck-Flyvholm, Claus Dahl, Nessn H Azawi

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

INTRODUCTION: The objective of this study was to determine the incidence of benign renal lesions for clinically localised renal masses and the need for new diagnostic procedures to assess these lesions.

MATERIAL AND METHODS: This retrospective study included patients who underwent partial or radical nephrectomy between November 2010 and July 2013. All patients underwent a multiphase helical computed tomography (CT), which revealed suspected renal malignancy. The exclusion criteria were cystic tumours, biopsy before surgery, and disseminated and locally advanced disease. Lesions were defined as follows: small ≤ 4 cm, intermediate > 4 and ≤ 7 cm, and large > 7 cm.

RESULTS: A total of 226 patients underwent radical or partial nephrectomy; of these 75 patients were excluded. In all, 151 had masses suspected of being malignant tumours on CT. The mean age was 62.9 years. The male: female ratio was 3:1. The distribution of small, intermediate and large lesions were 75 (49.7%), 47 (31.1%) and 29 (19.2%), respectively. Among the three types of lesions, 15 (20%), 5 (10.6%) and 3 (10.3%) were benign, respectively (p = 0.27). Partial nephrectomy was performed in 69.3% of patients with small tumours versus 23.4% of patients with intermediate tumours, p < 0.001.

CONCLUSION: Benign lesions were observed in 20% of small renal masses ≤ 4 cm even though CT revealed a suspect renal lesion. The need for new diagnostic approaches for clinically localised renal lesions is evident.

FUNDING: not relevant.

TRIAL REGISTRATION: not relevant.

OriginalsprogEngelsk
TidsskriftDanish medical bulletin
Vol/bind61
Udgave nummer10
Sider (fra-til)A4932
ISSN1603-9629
StatusUdgivet - okt. 2014

Fingeraftryk

Kidney
Nephrectomy
Neoplasms
Retrospective Studies
Incidence

Citer dette

Lindkvist Pedersen, C., Winck-Flyvholm, L., Dahl, C., & Azawi, N. H. (2014). High rate of benign histology in radiologically suspect renal lesions. Danish medical bulletin, 61(10), A4932.
Lindkvist Pedersen, Christina ; Winck-Flyvholm, Lili ; Dahl, Claus ; Azawi, Nessn H. / High rate of benign histology in radiologically suspect renal lesions. I: Danish medical bulletin. 2014 ; Bind 61, Nr. 10. s. A4932.
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abstract = "INTRODUCTION: The objective of this study was to determine the incidence of benign renal lesions for clinically localised renal masses and the need for new diagnostic procedures to assess these lesions.MATERIAL AND METHODS: This retrospective study included patients who underwent partial or radical nephrectomy between November 2010 and July 2013. All patients underwent a multiphase helical computed tomography (CT), which revealed suspected renal malignancy. The exclusion criteria were cystic tumours, biopsy before surgery, and disseminated and locally advanced disease. Lesions were defined as follows: small ≤ 4 cm, intermediate > 4 and ≤ 7 cm, and large > 7 cm.RESULTS: A total of 226 patients underwent radical or partial nephrectomy; of these 75 patients were excluded. In all, 151 had masses suspected of being malignant tumours on CT. The mean age was 62.9 years. The male: female ratio was 3:1. The distribution of small, intermediate and large lesions were 75 (49.7{\%}), 47 (31.1{\%}) and 29 (19.2{\%}), respectively. Among the three types of lesions, 15 (20{\%}), 5 (10.6{\%}) and 3 (10.3{\%}) were benign, respectively (p = 0.27). Partial nephrectomy was performed in 69.3{\%} of patients with small tumours versus 23.4{\%} of patients with intermediate tumours, p < 0.001.CONCLUSION: Benign lesions were observed in 20{\%} of small renal masses ≤ 4 cm even though CT revealed a suspect renal lesion. The need for new diagnostic approaches for clinically localised renal lesions is evident.FUNDING: not relevant.TRIAL REGISTRATION: not relevant.",
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Lindkvist Pedersen, C, Winck-Flyvholm, L, Dahl, C & Azawi, NH 2014, 'High rate of benign histology in radiologically suspect renal lesions', Danish medical bulletin, bind 61, nr. 10, s. A4932.

High rate of benign histology in radiologically suspect renal lesions. / Lindkvist Pedersen, Christina; Winck-Flyvholm, Lili; Dahl, Claus; Azawi, Nessn H.

I: Danish medical bulletin, Bind 61, Nr. 10, 10.2014, s. A4932.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - High rate of benign histology in radiologically suspect renal lesions

AU - Lindkvist Pedersen, Christina

AU - Winck-Flyvholm, Lili

AU - Dahl, Claus

AU - Azawi, Nessn H

PY - 2014/10

Y1 - 2014/10

N2 - INTRODUCTION: The objective of this study was to determine the incidence of benign renal lesions for clinically localised renal masses and the need for new diagnostic procedures to assess these lesions.MATERIAL AND METHODS: This retrospective study included patients who underwent partial or radical nephrectomy between November 2010 and July 2013. All patients underwent a multiphase helical computed tomography (CT), which revealed suspected renal malignancy. The exclusion criteria were cystic tumours, biopsy before surgery, and disseminated and locally advanced disease. Lesions were defined as follows: small ≤ 4 cm, intermediate > 4 and ≤ 7 cm, and large > 7 cm.RESULTS: A total of 226 patients underwent radical or partial nephrectomy; of these 75 patients were excluded. In all, 151 had masses suspected of being malignant tumours on CT. The mean age was 62.9 years. The male: female ratio was 3:1. The distribution of small, intermediate and large lesions were 75 (49.7%), 47 (31.1%) and 29 (19.2%), respectively. Among the three types of lesions, 15 (20%), 5 (10.6%) and 3 (10.3%) were benign, respectively (p = 0.27). Partial nephrectomy was performed in 69.3% of patients with small tumours versus 23.4% of patients with intermediate tumours, p < 0.001.CONCLUSION: Benign lesions were observed in 20% of small renal masses ≤ 4 cm even though CT revealed a suspect renal lesion. The need for new diagnostic approaches for clinically localised renal lesions is evident.FUNDING: not relevant.TRIAL REGISTRATION: not relevant.

AB - INTRODUCTION: The objective of this study was to determine the incidence of benign renal lesions for clinically localised renal masses and the need for new diagnostic procedures to assess these lesions.MATERIAL AND METHODS: This retrospective study included patients who underwent partial or radical nephrectomy between November 2010 and July 2013. All patients underwent a multiphase helical computed tomography (CT), which revealed suspected renal malignancy. The exclusion criteria were cystic tumours, biopsy before surgery, and disseminated and locally advanced disease. Lesions were defined as follows: small ≤ 4 cm, intermediate > 4 and ≤ 7 cm, and large > 7 cm.RESULTS: A total of 226 patients underwent radical or partial nephrectomy; of these 75 patients were excluded. In all, 151 had masses suspected of being malignant tumours on CT. The mean age was 62.9 years. The male: female ratio was 3:1. The distribution of small, intermediate and large lesions were 75 (49.7%), 47 (31.1%) and 29 (19.2%), respectively. Among the three types of lesions, 15 (20%), 5 (10.6%) and 3 (10.3%) were benign, respectively (p = 0.27). Partial nephrectomy was performed in 69.3% of patients with small tumours versus 23.4% of patients with intermediate tumours, p < 0.001.CONCLUSION: Benign lesions were observed in 20% of small renal masses ≤ 4 cm even though CT revealed a suspect renal lesion. The need for new diagnostic approaches for clinically localised renal lesions is evident.FUNDING: not relevant.TRIAL REGISTRATION: not relevant.

M3 - Journal article

VL - 61

SP - A4932

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 1603-9629

IS - 10

ER -

Lindkvist Pedersen C, Winck-Flyvholm L, Dahl C, Azawi NH. High rate of benign histology in radiologically suspect renal lesions. Danish medical bulletin. 2014 okt;61(10):A4932.