Resumé
To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.
Methods:
This was a cross-sectional study of 50-degree, disc-centred fundus photographs from 59 monozygotic and 55 dizygotic, same-sex twin pairs aged 20-46 years. The retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficents. Falconer´s formula and quantitative genetic models were used to determine the genetic component of variation.
Results:
The retinal vascular fractal dimensions were measurable for both twins in 50 monozygotic and 49 dizygotic twin pairs. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, p=0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, p=0.0002) in monozygotic twins than in dizygotic twins (0.108, p=0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, 54% of the variation was explained by dominant genetic effects and 46% was individually environmentally determined.
Conclusion:
In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the
| Originalsprog | Engelsk |
|---|---|
| Publikationsdato | 7. maj 2017 |
| Antal sider | 1 |
| Status | Udgivet - 7. maj 2017 |
| Begivenhed | Association for Research in Vision and Ophthalmology Annual Meeting 2017 - Baltimore, USA Varighed: 7. maj 2017 → 11. maj 2017 |
Konference
| Konference | Association for Research in Vision and Ophthalmology Annual Meeting 2017 |
|---|---|
| Land | USA |
| By | Baltimore |
| Periode | 07/05/2017 → 11/05/2017 |
Citer dette
}
Heritability of retinal vascular fractals: a twin study. / Vergmann, Anna Stage; Broe, Rebecca; Kessel, Line; Hougaard, Jesper Leth; Möller, Sören; Kyvik, Kirsten Ohm; Larsen, Michael; Munch, Inger Christine; Grauslund, Jakob.
2017. Poster session præsenteret på Association for Research in Vision and Ophthalmology Annual Meeting 2017, Baltimore, USA.Publikation: Konferencebidrag uden forlag/tidsskrift › Poster › Forskning › peer review
TY - CONF
T1 - Heritability of retinal vascular fractals: a twin study
AU - Vergmann, Anna Stage
AU - Broe, Rebecca
AU - Kessel, Line
AU - Hougaard, Jesper Leth
AU - Möller, Sören
AU - Kyvik, Kirsten Ohm
AU - Larsen, Michael
AU - Munch, Inger Christine
AU - Grauslund, Jakob
PY - 2017/5/7
Y1 - 2017/5/7
N2 - Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.Methods: This was a cross-sectional study of 50-degree, disc-centred fundus photographs from 59 monozygotic and 55 dizygotic, same-sex twin pairs aged 20-46 years. The retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficents. Falconer´s formula and quantitative genetic models were used to determine the genetic component of variation.Results: The retinal vascular fractal dimensions were measurable for both twins in 50 monozygotic and 49 dizygotic twin pairs. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, p=0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, p=0.0002) in monozygotic twins than in dizygotic twins (0.108, p=0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, 54% of the variation was explained by dominant genetic effects and 46% was individually environmentally determined.Conclusion: In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the
AB - Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension.Methods: This was a cross-sectional study of 50-degree, disc-centred fundus photographs from 59 monozygotic and 55 dizygotic, same-sex twin pairs aged 20-46 years. The retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficents. Falconer´s formula and quantitative genetic models were used to determine the genetic component of variation.Results: The retinal vascular fractal dimensions were measurable for both twins in 50 monozygotic and 49 dizygotic twin pairs. The mean fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, p=0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, p=0.0002) in monozygotic twins than in dizygotic twins (0.108, p=0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, 54% of the variation was explained by dominant genetic effects and 46% was individually environmentally determined.Conclusion: In young adult twins, the branching pattern of the retinal vessels demonstrated a higher structural similarity in monozygotic than in dizygotic twin pairs. The retinal vascular fractal dimension was mainly determined by genetic factors, which accounted for 54% of the variation. The genetically predetermination of the
M3 - Poster
ER -