Heritability and Genetic Relationship of Adult Self-Reported Stuttering, Cluttering and Childhood Speech-Language Disorders: Dziedzicznosc i genetyczne zaleznosci jakania, gielkotu i zaburzen rozwoju jezyka w opisie osób doroslych

Corrado Fagnani, Steen Fibiger, Axel Skytthe, Jacob von Bornemann Hjelmborg

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Genetic influence and mutual genetic relationship for adult self-reported childhood
speech-language disorders, stuttering, and cluttering were studied. Using nationwide
questionnaire answers from 34,944 adult Danish twins, a multivariate biometric analysis
based on the liability-threshold model was performed in order to estimate heritability of
the traits and genetic correlation between them.
The lifetime prevalence rates were in agreement with previous reports, and were
higher for males than for females for all three traits. The probandwise concordance rates
were always substantially higher for monozygotic compared to dizygotic pairs, suggesting
genetic influence. Multivariate biometric analyses showed that additive genetic and unique
environmental factors best explained the observed concordance patterns. Heritability
estimates for males/females were 0.71/0.87 for childhood speech-language disorders,
0.78/0.80 for stuttering, and 0.53/0.65 for cluttering. For each trait, the same genes were
suggested to affect liability in males and females. Furthermore, high genetic correlations
between the traits were obtained; the estimates for childhood speech-language disorders
and stuttering were 0.71/0.79 for males/females, for childhood speech-language disorders
and cluttering 0.73/0.56, and for stuttering and cluttering 0.53/0.57.
Substantial unique environmental correlations between the traits were also found in
both genders.
Conclusion: With the limitations related to self-reporting from adult age, this study
demonstrates substantial genetic influence on the traits of childhood speech-language
disorders, stuttering, and cluttering, and mutual genetic relationship between them.
OriginalsprogEngelsk
TidsskriftLogopedia
Vol/bind38
Sider (fra-til)71-100
Antal sider30
ISSN0459-6935
StatusUdgivet - 2011

Emneord

  • Stammen
  • Løbsk tale, Tale-sprogvanskeligheder hos børn, Tvillinger, Heritabilitet

Citationsformater