Henoch-Schönlein Purpura: A Literature Review

Liv Eline Hetland, Kjærsti Sørensen Susrud, Kim Hein Lindahl, Anette Bygum

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Resumé

Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointestinal tract, joints and kidneys. Corticosteroids may be effective in rapid resolution of renal manifestations and treating joint and abdominal pain, but they are not proven effective for treating organ manifestations and complications, such as glomerulonephritis, bowel infarction or intussusception. Mycophenolate mofetil or cyclosporine A may be better treatment choices in case of renal involvement. Other immunosuppressive and immunomodulating drugs, such as rituximab and dapsone, are promising, but larger studies are needed to confirm these findings. Cancer screening should be considered in older males diagnosed with Henoch-Schönlein purpura.

OriginalsprogEngelsk
Tidsskrift Acta Dermato-Venereologica
Vol/bind97
Udgave nummer10
Sider (fra-til)1160–1166
ISSN0001-5555
DOI
StatusUdgivet - 2017

Fingeraftryk

Schoenlein-Henoch Purpura
Kidney
Mycophenolic Acid
Intussusception
Immunosuppressive Agents
Glomerulonephritis
Early Detection of Cancer
Infarction
Cyclosporine
Gastrointestinal Tract
Adrenal Cortex Hormones
Joints
Skin
Pharmaceutical Preparations

Citer dette

Hetland, Liv Eline ; Susrud, Kjærsti Sørensen ; Lindahl, Kim Hein ; Bygum, Anette. / Henoch-Schönlein Purpura : A Literature Review. I: Acta Dermato-Venereologica. 2017 ; Bind 97, Nr. 10. s. 1160–1166.
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Henoch-Schönlein Purpura : A Literature Review. / Hetland, Liv Eline; Susrud, Kjærsti Sørensen; Lindahl, Kim Hein; Bygum, Anette.

I: Acta Dermato-Venereologica, Bind 97, Nr. 10, 2017, s. 1160–1166.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Henoch-Schönlein Purpura

T2 - A Literature Review

AU - Hetland, Liv Eline

AU - Susrud, Kjærsti Sørensen

AU - Lindahl, Kim Hein

AU - Bygum, Anette

PY - 2017

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N2 - Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointestinal tract, joints and kidneys. Corticosteroids may be effective in rapid resolution of renal manifestations and treating joint and abdominal pain, but they are not proven effective for treating organ manifestations and complications, such as glomerulonephritis, bowel infarction or intussusception. Mycophenolate mofetil or cyclosporine A may be better treatment choices in case of renal involvement. Other immunosuppressive and immunomodulating drugs, such as rituximab and dapsone, are promising, but larger studies are needed to confirm these findings. Cancer screening should be considered in older males diagnosed with Henoch-Schönlein purpura.

AB - Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein purpura. The clinical manifestations are thought to arise from IgA depositions in blood vessel walls in the affected organs, mostly skin, gastrointestinal tract, joints and kidneys. Corticosteroids may be effective in rapid resolution of renal manifestations and treating joint and abdominal pain, but they are not proven effective for treating organ manifestations and complications, such as glomerulonephritis, bowel infarction or intussusception. Mycophenolate mofetil or cyclosporine A may be better treatment choices in case of renal involvement. Other immunosuppressive and immunomodulating drugs, such as rituximab and dapsone, are promising, but larger studies are needed to confirm these findings. Cancer screening should be considered in older males diagnosed with Henoch-Schönlein purpura.

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DO - 10.2340/00015555-2733

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JO - Acta Dermatovenereologica

JF - Acta Dermatovenereologica

SN - 0001-5555

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