Hemodynamic and glucometabolic factors fail to predict renal function in a random population sample

M. Pareek, M. Nielsen, Thomas Bastholm Olesen, M. Leosdottir, P. M. Nilsson, M. H. Olsen

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review


Objective: To determine whether baseline hemodynamic and/or glucometabolic risk factors could predict renal function at follow-up, independently of baseline serum creatinine, in survivors from a random population sample. Design and method: We examined associations between baseline serum creatinine, hemodynamic factors (systolic blood pressure (SBP), heart rate (HR)), glucometabolic factors (fasting plasma glucose and insulin, 2-hour plasma glucose and insulin during oral glucose tolerance test (OGTT), a modified 40 minute oral disposition index (DIo), and Homeostatic Model Assessment (HOMA) derived indices of beta-cell function (HOMA-2B), insulin sensitivity (HOMA-2S), and insulin resistance (HOMA-2IR)), traditional cardiovascular risk factors (age, sex, smoking status, body mass index, diabetes mellitus, total serum cholesterol), and later renal function determined as serum cystatin C in 238 men and 7 women aged 38 to 49 years at the time of inclusion, using multivariable linear regression analysis (p-entry 0.05, p-removal 0.20). Study subjects came from a random population based sample and were included 1974-1992, whilst the follow-up with cystatin C measurement was performed 2002-2006. Results: Mean (+/- s.d.) follow-up time, creatinine, and cystatin C were 28 +/- 1 years, 94 +/- 12 micromoles/L, and 1.220 +/- 0.298 mg/L. Mean estimated glomerular filtration rates at baseline and follow-up were 84 +/- 12 mL/min/1.73m2 and 68 +/- 18 mL/min/1.73m2. In univariate analyses, cystatin C was positively associated with age, female sex, SBP, HOMA-2B, creatinine, and the time elapsed between inclusion and follow-up. In multivariable analysis, age (beta = 0.013 (95% confidence interval (CI), 0.002 to 0.024); p <0.02), female sex (beta = 0.271 (95% CI, 0.036 to 0.506); p = 0.02), creatinine (beta = 0.007 (95% CI, 0.004 to 0.010); p <0.001), and time span (beta = 0.062 (95% CI, 0.018 to 0.106); p = 0.006) remained significantly associated with cystatin C.We did not detect any significant interactions between SBP, HOMA-2B, and the other risk factors. Conclusions: Although SBP and HOMA-2B were both associated with later renal function as assessed by serum cystatin C, none of them remained significant in a multivariable model adjusted for age, sex, serum creatinine, and time from inclusion to follow-up.
TidsskriftJournal of Hypertension
Udgave nummere-Supplement 1
Sider (fra-til)e352
Antal sider1
StatusUdgivet - 2015
Begivenhed25th European Meeting on Hypertension and Cardiovascular Protection - Milano, Italien
Varighed: 12. jun. 201515. jun. 2015


Konference25th European Meeting on Hypertension and Cardiovascular Protection


  • *population *European *hypertension *protection *kidney function follow up female creatinine blood level model risk factor glucose blood level serum human oral glucose tolerance test insulin sensitivity cell function heart rate linear regression analysis male systolic blood pressure cholesterol blood level diabetes mellitus body mass smoking diet restriction cardiovascular risk insulin resistance univariate analysis glomerulus filtration rate confidence interval survivor cystatin C creatinine insulin cystatin