Helicobacter pylori among preschool children and their parents: evidence of parent-child transmission

D Rothenbacher, G Bode, Gabriele Berg, U Knayer, T Gonser, G Adler, H Brenner

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

This study assessed the role of parental infection status in the transmission of Helicobacter pylori infection in a large population-based sample of preschool-aged children. The subjects, who lived in Ulm, Germany, and in two nearby communities, were screened for school fitness between January and July 1997. Their H. pylori infection status was determined by 13C-urea breath test. Of 1522 eligible children, 1221 (80.2%) participated in the study. Crude prevalence of H. pylori infection in children was 11.3% (95% confidence interval [CI], 9.5-13.3) and 36.4% in their parents (95% CI, 33.5-39.4). The crude odds ratio (OR) for H. pylori infection of children whose mothers were infected was 16.5 (95% CI, 8.9-30.8) and 7.9 after adjustment for potential confounders (95% CI, 4.0-15.7). The crude OR if the child's father was infected was 7.8 (95% CI, 2. 5-24.2) and 3.8 after adjustment for potential confounders (except maternal infection) (95% CI, 0.8-19.1). The results suggest that infected parents, especially infected mothers, may have a key role in transmission of H. pylori within families.

OriginalsprogEngelsk
TidsskriftJournal of Infectious Diseases
Vol/bind179
Udgave nummer2
Sider (fra-til)398-402
Antal sider5
ISSN0022-1899
DOI
StatusUdgivet - feb. 1999

Fingeraftryk

Preschool Children
Helicobacter pylori
Parents
Helicobacter Infections
Confidence Intervals
Mothers
Odds Ratio
Fathers
Germany
Urea
Population

Citer dette

Rothenbacher, D ; Bode, G ; Berg, Gabriele ; Knayer, U ; Gonser, T ; Adler, G ; Brenner, H. / Helicobacter pylori among preschool children and their parents : evidence of parent-child transmission. I: Journal of Infectious Diseases. 1999 ; Bind 179, Nr. 2. s. 398-402.
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abstract = "This study assessed the role of parental infection status in the transmission of Helicobacter pylori infection in a large population-based sample of preschool-aged children. The subjects, who lived in Ulm, Germany, and in two nearby communities, were screened for school fitness between January and July 1997. Their H. pylori infection status was determined by 13C-urea breath test. Of 1522 eligible children, 1221 (80.2{\%}) participated in the study. Crude prevalence of H. pylori infection in children was 11.3{\%} (95{\%} confidence interval [CI], 9.5-13.3) and 36.4{\%} in their parents (95{\%} CI, 33.5-39.4). The crude odds ratio (OR) for H. pylori infection of children whose mothers were infected was 16.5 (95{\%} CI, 8.9-30.8) and 7.9 after adjustment for potential confounders (95{\%} CI, 4.0-15.7). The crude OR if the child's father was infected was 7.8 (95{\%} CI, 2. 5-24.2) and 3.8 after adjustment for potential confounders (except maternal infection) (95{\%} CI, 0.8-19.1). The results suggest that infected parents, especially infected mothers, may have a key role in transmission of H. pylori within families.",
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Helicobacter pylori among preschool children and their parents : evidence of parent-child transmission. / Rothenbacher, D; Bode, G; Berg, Gabriele; Knayer, U; Gonser, T; Adler, G; Brenner, H.

I: Journal of Infectious Diseases, Bind 179, Nr. 2, 02.1999, s. 398-402.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Helicobacter pylori among preschool children and their parents

T2 - evidence of parent-child transmission

AU - Rothenbacher, D

AU - Bode, G

AU - Berg, Gabriele

AU - Knayer, U

AU - Gonser, T

AU - Adler, G

AU - Brenner, H

PY - 1999/2

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N2 - This study assessed the role of parental infection status in the transmission of Helicobacter pylori infection in a large population-based sample of preschool-aged children. The subjects, who lived in Ulm, Germany, and in two nearby communities, were screened for school fitness between January and July 1997. Their H. pylori infection status was determined by 13C-urea breath test. Of 1522 eligible children, 1221 (80.2%) participated in the study. Crude prevalence of H. pylori infection in children was 11.3% (95% confidence interval [CI], 9.5-13.3) and 36.4% in their parents (95% CI, 33.5-39.4). The crude odds ratio (OR) for H. pylori infection of children whose mothers were infected was 16.5 (95% CI, 8.9-30.8) and 7.9 after adjustment for potential confounders (95% CI, 4.0-15.7). The crude OR if the child's father was infected was 7.8 (95% CI, 2. 5-24.2) and 3.8 after adjustment for potential confounders (except maternal infection) (95% CI, 0.8-19.1). The results suggest that infected parents, especially infected mothers, may have a key role in transmission of H. pylori within families.

AB - This study assessed the role of parental infection status in the transmission of Helicobacter pylori infection in a large population-based sample of preschool-aged children. The subjects, who lived in Ulm, Germany, and in two nearby communities, were screened for school fitness between January and July 1997. Their H. pylori infection status was determined by 13C-urea breath test. Of 1522 eligible children, 1221 (80.2%) participated in the study. Crude prevalence of H. pylori infection in children was 11.3% (95% confidence interval [CI], 9.5-13.3) and 36.4% in their parents (95% CI, 33.5-39.4). The crude odds ratio (OR) for H. pylori infection of children whose mothers were infected was 16.5 (95% CI, 8.9-30.8) and 7.9 after adjustment for potential confounders (95% CI, 4.0-15.7). The crude OR if the child's father was infected was 7.8 (95% CI, 2. 5-24.2) and 3.8 after adjustment for potential confounders (except maternal infection) (95% CI, 0.8-19.1). The results suggest that infected parents, especially infected mothers, may have a key role in transmission of H. pylori within families.

KW - Adult

KW - Child

KW - Child, Preschool

KW - Family Health

KW - Female

KW - Helicobacter Infections

KW - Helicobacter pylori

KW - Humans

KW - Male

KW - Sex Distribution

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

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