Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder

Takashi Yorifuji, Kenichi Matsuoka, Philippe Grandjean

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Resumé

BACKGROUND: Arsenic poisoning interferes with bone metabolism in laboratory animal studies, and human studies suggest lowered bone mass density at elevated exposures. As the long-term consequences of developmental arsenic toxicity are poorly known, we carried out a clinical pilot study of survivors of the mass arsenic poisoning of bottle-fed infants in Japan in 1955.

OBJECTIVES: The purpose was to evaluate the association between developmental arsenic exposure and physical stature and routine blood chemistry reflecting major organ functions more than 50 years later.

METHODS: The study sample consisted of 50 individuals recruited at two hospitals in Okayama Prefecture, Japan: 27 known poisoning victims (14 men and 13 women), and 23 non-exposed local controls of similar age (10 men, 13 women). We collected information from physical examinations that included routine blood counts and blood biochemistry.

RESULTS: The average height of the exposed group was 6.5cm below that of the unexposed group (p=0.02), while the latter was in accordance with national data for both sexes. In addition, the exposed participants had a higher mean (SD) serum concentration of alkaline phosphatase (ALP) of 233 (63) U/L than the unexposed participants (191 (44) U/L) (p=0.01). No other statistically significant difference was observed, and liver enzymes were within normal ranges.

CONCLUSIONS: Adults who had suffered arsenic poisoning during infancy showed decreased height and elevated ALP that suggests abnormalities in bone metabolism possibly induced by arsenic incorporated in the bone matrix.

OriginalsprogEngelsk
TidsskriftEnvironmental Research
Vol/bind155
Sider (fra-til)86-91
ISSN0013-9351
DOI
StatusUdgivet - 2017

Fingeraftryk

Arsenic Poisoning
Arsenic
poisoning
Powders
milk
arsenic
Blood
blood
Alkaline Phosphatase
bone
Japan
Bone
history
Metabolism
phosphatase
Bone Density
Poisoning
Physical Examination
Survivors
Reference Values

Citer dette

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title = "Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder",
abstract = "BACKGROUND: Arsenic poisoning interferes with bone metabolism in laboratory animal studies, and human studies suggest lowered bone mass density at elevated exposures. As the long-term consequences of developmental arsenic toxicity are poorly known, we carried out a clinical pilot study of survivors of the mass arsenic poisoning of bottle-fed infants in Japan in 1955.OBJECTIVES: The purpose was to evaluate the association between developmental arsenic exposure and physical stature and routine blood chemistry reflecting major organ functions more than 50 years later.METHODS: The study sample consisted of 50 individuals recruited at two hospitals in Okayama Prefecture, Japan: 27 known poisoning victims (14 men and 13 women), and 23 non-exposed local controls of similar age (10 men, 13 women). We collected information from physical examinations that included routine blood counts and blood biochemistry.RESULTS: The average height of the exposed group was 6.5cm below that of the unexposed group (p=0.02), while the latter was in accordance with national data for both sexes. In addition, the exposed participants had a higher mean (SD) serum concentration of alkaline phosphatase (ALP) of 233 (63) U/L than the unexposed participants (191 (44) U/L) (p=0.01). No other statistically significant difference was observed, and liver enzymes were within normal ranges.CONCLUSIONS: Adults who had suffered arsenic poisoning during infancy showed decreased height and elevated ALP that suggests abnormalities in bone metabolism possibly induced by arsenic incorporated in the bone matrix.",
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Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder. / Yorifuji, Takashi; Matsuoka, Kenichi; Grandjean, Philippe.

I: Environmental Research, Bind 155, 2017, s. 86-91.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Height and blood chemistry in adults with a history of developmental arsenic poisoning from contaminated milk powder

AU - Yorifuji, Takashi

AU - Matsuoka, Kenichi

AU - Grandjean, Philippe

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Arsenic poisoning interferes with bone metabolism in laboratory animal studies, and human studies suggest lowered bone mass density at elevated exposures. As the long-term consequences of developmental arsenic toxicity are poorly known, we carried out a clinical pilot study of survivors of the mass arsenic poisoning of bottle-fed infants in Japan in 1955.OBJECTIVES: The purpose was to evaluate the association between developmental arsenic exposure and physical stature and routine blood chemistry reflecting major organ functions more than 50 years later.METHODS: The study sample consisted of 50 individuals recruited at two hospitals in Okayama Prefecture, Japan: 27 known poisoning victims (14 men and 13 women), and 23 non-exposed local controls of similar age (10 men, 13 women). We collected information from physical examinations that included routine blood counts and blood biochemistry.RESULTS: The average height of the exposed group was 6.5cm below that of the unexposed group (p=0.02), while the latter was in accordance with national data for both sexes. In addition, the exposed participants had a higher mean (SD) serum concentration of alkaline phosphatase (ALP) of 233 (63) U/L than the unexposed participants (191 (44) U/L) (p=0.01). No other statistically significant difference was observed, and liver enzymes were within normal ranges.CONCLUSIONS: Adults who had suffered arsenic poisoning during infancy showed decreased height and elevated ALP that suggests abnormalities in bone metabolism possibly induced by arsenic incorporated in the bone matrix.

AB - BACKGROUND: Arsenic poisoning interferes with bone metabolism in laboratory animal studies, and human studies suggest lowered bone mass density at elevated exposures. As the long-term consequences of developmental arsenic toxicity are poorly known, we carried out a clinical pilot study of survivors of the mass arsenic poisoning of bottle-fed infants in Japan in 1955.OBJECTIVES: The purpose was to evaluate the association between developmental arsenic exposure and physical stature and routine blood chemistry reflecting major organ functions more than 50 years later.METHODS: The study sample consisted of 50 individuals recruited at two hospitals in Okayama Prefecture, Japan: 27 known poisoning victims (14 men and 13 women), and 23 non-exposed local controls of similar age (10 men, 13 women). We collected information from physical examinations that included routine blood counts and blood biochemistry.RESULTS: The average height of the exposed group was 6.5cm below that of the unexposed group (p=0.02), while the latter was in accordance with national data for both sexes. In addition, the exposed participants had a higher mean (SD) serum concentration of alkaline phosphatase (ALP) of 233 (63) U/L than the unexposed participants (191 (44) U/L) (p=0.01). No other statistically significant difference was observed, and liver enzymes were within normal ranges.CONCLUSIONS: Adults who had suffered arsenic poisoning during infancy showed decreased height and elevated ALP that suggests abnormalities in bone metabolism possibly induced by arsenic incorporated in the bone matrix.

KW - Journal Article

U2 - 10.1016/j.envres.2017.02.002

DO - 10.1016/j.envres.2017.02.002

M3 - Journal article

VL - 155

SP - 86

EP - 91

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -