Heat penetration in locally applied hyperthermia in the abdomen during intra-operative hyperthermic intraperitoneal chemotherapy

S Van Ruth*, VJ Verwaal, AAM Hart, GW Van Slooten, FAN Zoetmulder

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Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C has been applied following cytoreductive surgery for various peritoneal surface malignancies. The aim of this study was to evaluate heat penetration in the abdomen during 10 HIPEC procedures. Materials and Methods: Temperature measurements were taken at 5 levels through the abdominal wall. Core temperature and room temperature were also measured. The relationships between the temperature gradient and room or core temperature were studied. Results: At the start Of perfusion, the temperature was estimated on average to be 40.6degreesC at the first level. then it decreased by 1.7degreesC (SD 1.0degreesC, p = 0.0001) in the first mm. In outward direction, it decreases by a further 1.5degreesC per cm (SD 0.3degreesC/cm, p

TidsskriftAnticancer Research
Udgave nummer2B
Sider (fra-til)1501-1508
Antal sider8
StatusUdgivet - 2003
Udgivet eksterntJa