TY - JOUR
T1 - Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy
AU - Wulff, Nille B.
AU - Dalton, Susanne O.
AU - Wessel, Irene
AU - Arenaz Búa, Beatriz
AU - Löfhede, Helena
AU - Hammerlid, Eva
AU - Kjaer, Trille K.
AU - Godballe, Christian
AU - Kjærgaard, Thomas
AU - Homøe, Preben
N1 - Funding Information:
This study was funded by the Region Zealand Fund for Health and Medical Sciences, the University of Copenhagen Fund for Cancer Research, the Medical Component of the Faculty of Health and Medical Sciences Fund for Scientific Staff, the Danish Cancer Research Fund, and the Danish‐Swedish Cooperation Fund.
PY - 2022/5
Y1 - 2022/5
N2 - Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Results: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score. Conclusion: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL. Level of Evidence: 3 Laryngoscope, 132:980–988, 2022.
AB - Objectives/Hypothesis: The aims were to determine health-related quality of life (HRQoL), including voice problems, dysphagia, depression, and anxiety after total laryngectomy (TL), and investigate the associations between HRQoL and the late effects. Study Design: Cross-sectional study. Methods: 172 participants having received a TL 1.6 to 18.1 years ago for laryngeal/hypopharyngeal cancer filled in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire, Core and Head and Neck module (EORTC QLQ-C30, EORTC QLQ-H&N35), Voice-Related Quality of Life questionnaire (V-RQOL), M.D. Anderson Dysphagia Inventory (MDADI), and Hospital Anxiety and Depression Scale (HADS) questionnaires. Results: Participants scored worse than normative reference populations on all scales/items of the EORTC questionnaires, except one, and almost half of the scales/items showed a clinically relevant difference. Moderate/severe dysphagia was present in 46%, moderate/severe voice problems in 57%, depression in 16%, and anxiety in 20%. Decreasing age, increasing numbers of comorbidities, increasing voice problems, increasing dysphagia, and increasing depression symptoms, were associated with a lowered EORTC QLQ-C30 summary score. Conclusion: A substantial proportion of participants experienced clinically significant late effects and increasing levels of these were associated with a lowered HRQoL. Level of Evidence: 3 Laryngoscope, 132:980–988, 2022.
KW - depression
KW - dysphagia
KW - health-related quality of life
KW - Total laryngectomy
KW - voice problems
KW - Anxiety/epidemiology
KW - Cross-Sectional Studies
KW - Laryngectomy/adverse effects
KW - Humans
KW - Deglutition Disorders/epidemiology
KW - Voice Disorders
KW - Laryngeal Neoplasms/surgery
KW - Depression/epidemiology
KW - Quality of Life
KW - Surveys and Questionnaires
U2 - 10.1002/lary.29857
DO - 10.1002/lary.29857
M3 - Journal article
C2 - 34490903
AN - SCOPUS:85114472353
SN - 0023-852X
VL - 132
SP - 980
EP - 988
JO - Laryngoscope
JF - Laryngoscope
IS - 5
ER -