Harmonising measures of knee and hip osteoarthritis in population-based cohort studies: an international study

K M Leyland, L S Gates, M Nevitt, D Felson, S M Bierma-Zeinstra, P G Conaghan, L Engebretsen, M Hochberg, D J Hunter, G Jones, J M Jordan, A Judge, L S Lohmander, E M Roos, M T Sanchez-Santos, N Yoshimura, J B J van Meurs, M E Batt, J Newton, C CooperN K Arden

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Resumé

OBJECTIVE: Population-based osteoarthritis (OA) cohorts provide vital data on risk factors and outcomes of OA, however the methods to define OA vary between cohorts. We aimed to provide recommendations for combining knee and hip OA data in extant and future population cohort studies, in order to facilitate informative individual participant level analyses.

METHOD: International OA experts met to make recommendations on: 1) defining OA by X-ray and/or pain; 2) compare The National Health and Nutrition Examination Survey (NHANES)-type OA pain questions; 3) the comparability of the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) scale to NHANES-type OA pain questions; 4) the best radiographic scoring method; 5) the usefulness of other OA outcome measures. Key issues were explored using new analyses in two population-based OA cohorts (Multicenter Osteoarthritis Study; MOST and Osteoarthritis Initiative OAI).

RESULTS: OA should be defined by both symptoms and radiographs, with symptoms alone as a secondary definition. Kellgren and Lawrence (K/L) grade ≥2 should be used to define radiographic OA (ROA). The variable wording of pain questions can result in varying prevalence between 41.0% and 75.4%, however questions where the time anchor is similar have high sensitivity and specificity (91.2% and 89.9% respectively). A threshold of 3 on a 0-20 scale (95% CI 2.1, 3.9) in the WOMAC pain subscale demonstrated equivalence with the preferred NHANES-type question.

CONCLUSION: This research provides recommendations, based on expert agreement, for harmonising and combining OA data in existing and future population-based cohorts.

OriginalsprogEngelsk
TidsskriftOsteoarthritis and Cartilage
Vol/bind26
Udgave nummer7
Sider (fra-til)872-879
ISSN1063-4584
DOI
StatusUdgivet - jul. 2018

Fingeraftryk

Hip Osteoarthritis
Knee Osteoarthritis
Nutrition
Cohort Studies
Health
Population
Anchors
Nutrition Surveys
X rays
Ontario

Citer dette

Leyland, K. M., Gates, L. S., Nevitt, M., Felson, D., Bierma-Zeinstra, S. M., Conaghan, P. G., ... Arden, N. K. (2018). Harmonising measures of knee and hip osteoarthritis in population-based cohort studies: an international study. Osteoarthritis and Cartilage, 26(7), 872-879. https://doi.org/10.1016/j.joca.2018.01.024
Leyland, K M ; Gates, L S ; Nevitt, M ; Felson, D ; Bierma-Zeinstra, S M ; Conaghan, P G ; Engebretsen, L ; Hochberg, M ; Hunter, D J ; Jones, G ; Jordan, J M ; Judge, A ; Lohmander, L S ; Roos, E M ; Sanchez-Santos, M T ; Yoshimura, N ; van Meurs, J B J ; Batt, M E ; Newton, J ; Cooper, C ; Arden, N K. / Harmonising measures of knee and hip osteoarthritis in population-based cohort studies : an international study. I: Osteoarthritis and Cartilage. 2018 ; Bind 26, Nr. 7. s. 872-879.
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title = "Harmonising measures of knee and hip osteoarthritis in population-based cohort studies: an international study",
abstract = "OBJECTIVE: Population-based osteoarthritis (OA) cohorts provide vital data on risk factors and outcomes of OA, however the methods to define OA vary between cohorts. We aimed to provide recommendations for combining knee and hip OA data in extant and future population cohort studies, in order to facilitate informative individual participant level analyses.METHOD: International OA experts met to make recommendations on: 1) defining OA by X-ray and/or pain; 2) compare The National Health and Nutrition Examination Survey (NHANES)-type OA pain questions; 3) the comparability of the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) scale to NHANES-type OA pain questions; 4) the best radiographic scoring method; 5) the usefulness of other OA outcome measures. Key issues were explored using new analyses in two population-based OA cohorts (Multicenter Osteoarthritis Study; MOST and Osteoarthritis Initiative OAI).RESULTS: OA should be defined by both symptoms and radiographs, with symptoms alone as a secondary definition. Kellgren and Lawrence (K/L) grade ≥2 should be used to define radiographic OA (ROA). The variable wording of pain questions can result in varying prevalence between 41.0{\%} and 75.4{\%}, however questions where the time anchor is similar have high sensitivity and specificity (91.2{\%} and 89.9{\%} respectively). A threshold of 3 on a 0-20 scale (95{\%} CI 2.1, 3.9) in the WOMAC pain subscale demonstrated equivalence with the preferred NHANES-type question.CONCLUSION: This research provides recommendations, based on expert agreement, for harmonising and combining OA data in existing and future population-based cohorts.",
keywords = "Cohort, Data, Epidemiology, Harmonisation, Osteoarthritis",
author = "Leyland, {K M} and Gates, {L S} and M Nevitt and D Felson and Bierma-Zeinstra, {S M} and Conaghan, {P G} and L Engebretsen and M Hochberg and Hunter, {D J} and G Jones and Jordan, {J M} and A Judge and Lohmander, {L S} and Roos, {E M} and Sanchez-Santos, {M T} and N Yoshimura and {van Meurs}, {J B J} and Batt, {M E} and J Newton and C Cooper and Arden, {N K}",
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Leyland, KM, Gates, LS, Nevitt, M, Felson, D, Bierma-Zeinstra, SM, Conaghan, PG, Engebretsen, L, Hochberg, M, Hunter, DJ, Jones, G, Jordan, JM, Judge, A, Lohmander, LS, Roos, EM, Sanchez-Santos, MT, Yoshimura, N, van Meurs, JBJ, Batt, ME, Newton, J, Cooper, C & Arden, NK 2018, 'Harmonising measures of knee and hip osteoarthritis in population-based cohort studies: an international study', Osteoarthritis and Cartilage, bind 26, nr. 7, s. 872-879. https://doi.org/10.1016/j.joca.2018.01.024

Harmonising measures of knee and hip osteoarthritis in population-based cohort studies : an international study. / Leyland, K M; Gates, L S; Nevitt, M; Felson, D; Bierma-Zeinstra, S M; Conaghan, P G; Engebretsen, L; Hochberg, M; Hunter, D J; Jones, G; Jordan, J M; Judge, A; Lohmander, L S; Roos, E M; Sanchez-Santos, M T; Yoshimura, N; van Meurs, J B J; Batt, M E; Newton, J; Cooper, C; Arden, N K.

I: Osteoarthritis and Cartilage, Bind 26, Nr. 7, 07.2018, s. 872-879.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Harmonising measures of knee and hip osteoarthritis in population-based cohort studies

T2 - an international study

AU - Leyland, K M

AU - Gates, L S

AU - Nevitt, M

AU - Felson, D

AU - Bierma-Zeinstra, S M

AU - Conaghan, P G

AU - Engebretsen, L

AU - Hochberg, M

AU - Hunter, D J

AU - Jones, G

AU - Jordan, J M

AU - Judge, A

AU - Lohmander, L S

AU - Roos, E M

AU - Sanchez-Santos, M T

AU - Yoshimura, N

AU - van Meurs, J B J

AU - Batt, M E

AU - Newton, J

AU - Cooper, C

AU - Arden, N K

N1 - Copyright © 2018. Published by Elsevier Ltd.

PY - 2018/7

Y1 - 2018/7

N2 - OBJECTIVE: Population-based osteoarthritis (OA) cohorts provide vital data on risk factors and outcomes of OA, however the methods to define OA vary between cohorts. We aimed to provide recommendations for combining knee and hip OA data in extant and future population cohort studies, in order to facilitate informative individual participant level analyses.METHOD: International OA experts met to make recommendations on: 1) defining OA by X-ray and/or pain; 2) compare The National Health and Nutrition Examination Survey (NHANES)-type OA pain questions; 3) the comparability of the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) scale to NHANES-type OA pain questions; 4) the best radiographic scoring method; 5) the usefulness of other OA outcome measures. Key issues were explored using new analyses in two population-based OA cohorts (Multicenter Osteoarthritis Study; MOST and Osteoarthritis Initiative OAI).RESULTS: OA should be defined by both symptoms and radiographs, with symptoms alone as a secondary definition. Kellgren and Lawrence (K/L) grade ≥2 should be used to define radiographic OA (ROA). The variable wording of pain questions can result in varying prevalence between 41.0% and 75.4%, however questions where the time anchor is similar have high sensitivity and specificity (91.2% and 89.9% respectively). A threshold of 3 on a 0-20 scale (95% CI 2.1, 3.9) in the WOMAC pain subscale demonstrated equivalence with the preferred NHANES-type question.CONCLUSION: This research provides recommendations, based on expert agreement, for harmonising and combining OA data in existing and future population-based cohorts.

AB - OBJECTIVE: Population-based osteoarthritis (OA) cohorts provide vital data on risk factors and outcomes of OA, however the methods to define OA vary between cohorts. We aimed to provide recommendations for combining knee and hip OA data in extant and future population cohort studies, in order to facilitate informative individual participant level analyses.METHOD: International OA experts met to make recommendations on: 1) defining OA by X-ray and/or pain; 2) compare The National Health and Nutrition Examination Survey (NHANES)-type OA pain questions; 3) the comparability of the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) scale to NHANES-type OA pain questions; 4) the best radiographic scoring method; 5) the usefulness of other OA outcome measures. Key issues were explored using new analyses in two population-based OA cohorts (Multicenter Osteoarthritis Study; MOST and Osteoarthritis Initiative OAI).RESULTS: OA should be defined by both symptoms and radiographs, with symptoms alone as a secondary definition. Kellgren and Lawrence (K/L) grade ≥2 should be used to define radiographic OA (ROA). The variable wording of pain questions can result in varying prevalence between 41.0% and 75.4%, however questions where the time anchor is similar have high sensitivity and specificity (91.2% and 89.9% respectively). A threshold of 3 on a 0-20 scale (95% CI 2.1, 3.9) in the WOMAC pain subscale demonstrated equivalence with the preferred NHANES-type question.CONCLUSION: This research provides recommendations, based on expert agreement, for harmonising and combining OA data in existing and future population-based cohorts.

KW - Cohort

KW - Data

KW - Epidemiology

KW - Harmonisation

KW - Osteoarthritis

U2 - 10.1016/j.joca.2018.01.024

DO - 10.1016/j.joca.2018.01.024

M3 - Journal article

C2 - 29426005

VL - 26

SP - 872

EP - 879

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 7

ER -