Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure

Jonel Trebicka*, Thomas Reiberger, Wim Laleman

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

56 Downloads (Pure)

Resumé

Acute-on-chronic liver failure (ACLF) is considered a distinct syndrome in patients with liver disease, with systemic inflammation playing a central role. Portal hypertension (PHT) is also aggravated by inflammation and may subsequently impact the course of ACLF. PHT is more than just an increase in portal pressure in the portal venous system; it aggravates the course of liver disease and, thus, also facilitates the development of acute decompensation and ACLF. A critical mechanistic link between PHT and ACLF might be the gut-liver axis, which is discussed in this review.

OriginalsprogEngelsk
TidsskriftVisceral Medicine
Vol/bind34
Udgave nummer4
Sider (fra-til)270-275
ISSN2297-4725
DOI
StatusUdgivet - aug. 2018

Fingeraftryk

Portal Hypertension
Liver
Liver Diseases
Portal Pressure
Acute-On-Chronic Liver Failure

Citer dette

Trebicka, Jonel ; Reiberger, Thomas ; Laleman, Wim. / Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure. I: Visceral Medicine. 2018 ; Bind 34, Nr. 4. s. 270-275.
@article{26b7eb254a97410f8d8446e5eb0adf6c,
title = "Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure",
abstract = "Acute-on-chronic liver failure (ACLF) is considered a distinct syndrome in patients with liver disease, with systemic inflammation playing a central role. Portal hypertension (PHT) is also aggravated by inflammation and may subsequently impact the course of ACLF. PHT is more than just an increase in portal pressure in the portal venous system; it aggravates the course of liver disease and, thus, also facilitates the development of acute decompensation and ACLF. A critical mechanistic link between PHT and ACLF might be the gut-liver axis, which is discussed in this review.",
keywords = "Acute-on-chronic liver failure, ACLF, Bacterial translocation, Microbiome, Portal hypertension, Systemic inflammation",
author = "Jonel Trebicka and Thomas Reiberger and Wim Laleman",
year = "2018",
month = "8",
doi = "10.1159/000490262",
language = "English",
volume = "34",
pages = "270--275",
journal = "Visceral Medicine",
issn = "2297-4725",
publisher = "S. Karger AG",
number = "4",

}

Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure. / Trebicka, Jonel; Reiberger, Thomas; Laleman, Wim.

I: Visceral Medicine, Bind 34, Nr. 4, 08.2018, s. 270-275.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure

AU - Trebicka, Jonel

AU - Reiberger, Thomas

AU - Laleman, Wim

PY - 2018/8

Y1 - 2018/8

N2 - Acute-on-chronic liver failure (ACLF) is considered a distinct syndrome in patients with liver disease, with systemic inflammation playing a central role. Portal hypertension (PHT) is also aggravated by inflammation and may subsequently impact the course of ACLF. PHT is more than just an increase in portal pressure in the portal venous system; it aggravates the course of liver disease and, thus, also facilitates the development of acute decompensation and ACLF. A critical mechanistic link between PHT and ACLF might be the gut-liver axis, which is discussed in this review.

AB - Acute-on-chronic liver failure (ACLF) is considered a distinct syndrome in patients with liver disease, with systemic inflammation playing a central role. Portal hypertension (PHT) is also aggravated by inflammation and may subsequently impact the course of ACLF. PHT is more than just an increase in portal pressure in the portal venous system; it aggravates the course of liver disease and, thus, also facilitates the development of acute decompensation and ACLF. A critical mechanistic link between PHT and ACLF might be the gut-liver axis, which is discussed in this review.

KW - Acute-on-chronic liver failure, ACLF

KW - Bacterial translocation

KW - Microbiome

KW - Portal hypertension

KW - Systemic inflammation

U2 - 10.1159/000490262

DO - 10.1159/000490262

M3 - Review

C2 - 30345284

AN - SCOPUS:85051067488

VL - 34

SP - 270

EP - 275

JO - Visceral Medicine

JF - Visceral Medicine

SN - 2297-4725

IS - 4

ER -