Guillain–Barré syndrome in Denmark

a population-based study on epidemiology, diagnosis and clinical severity

Helle Al-Hakem*, Søren H. Sindrup, Henning Andersen, Charlotte Dornonville de la Cour, Lisbeth L. Lassen, Bianca van den Berg, Bart C. Jacobs, Thomas Harbo

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftLetterForskningpeer review

Resumé

OBJECTIVES: To describe the epidemiology and clinical heterogeneity of Guillain-Barré syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS).

METHODS: The incidence rate (IR) of GBS in Denmark from September 2012 to December 2015, applying the National Institute of Neurological Disorders and Stroke (NINDS) diagnostic criteria, was estimated and the level of diagnostic certainty was described with the Brighton criteria. All cases registered with a diagnosis of GBS or other inflammatory neuropathies in the Danish National Hospital Registry were reviewed for diagnostic criteria and for information on treatment and clinical course.

RESULTS: A total of 299 GBS cases were confirmed, corresponding to a crude IR of 1.59 (95% CI 1.42-1.78) per 100,000 per year. The Brighton criteria level 1-3 of diagnostic certainty was met in 279 (93%) of the patients. Thirty-five percent of the patients were mildly affected (GBS disability score < 3) and a correlation between high age and high disability score at nadir was found (Spearman's rank correlation coefficient 0.42, p < 0.0001). The group of 89 (30%) patients who were enrolled in IGOS had higher GBS disability score at nadir, were admitted 5 days earlier, reached nadir 4 days faster, and a larger proportion received treatment with IVIg (all p < 0.05).

CONCLUSION: The epidemiology and full clinical spectrum of GBS are described in a population-based study. This includes a larger proportion of milder cases that are underrepresented in prospective cohorts such as IGOS.

OriginalsprogEngelsk
TidsskriftJournal of Neurology
Vol/bind266
Udgave nummer2
Sider (fra-til)440–449
ISSN0340-5354
DOI
StatusUdgivet - feb. 2019

Fingeraftryk

Denmark
Epidemiology
Population
Outcome Assessment (Health Care)
National Institute of Neurological Disorders and Stroke
Incidence
Nonparametric Statistics
Registries

Citer dette

Al-Hakem, Helle ; Sindrup, Søren H. ; Andersen, Henning ; de la Cour, Charlotte Dornonville ; Lassen, Lisbeth L. ; van den Berg, Bianca ; Jacobs, Bart C. ; Harbo, Thomas. / Guillain–Barré syndrome in Denmark : a population-based study on epidemiology, diagnosis and clinical severity. I: Journal of Neurology. 2019 ; Bind 266, Nr. 2. s. 440–449.
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abstract = "OBJECTIVES: To describe the epidemiology and clinical heterogeneity of Guillain-Barr{\'e} syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS).METHODS: The incidence rate (IR) of GBS in Denmark from September 2012 to December 2015, applying the National Institute of Neurological Disorders and Stroke (NINDS) diagnostic criteria, was estimated and the level of diagnostic certainty was described with the Brighton criteria. All cases registered with a diagnosis of GBS or other inflammatory neuropathies in the Danish National Hospital Registry were reviewed for diagnostic criteria and for information on treatment and clinical course.RESULTS: A total of 299 GBS cases were confirmed, corresponding to a crude IR of 1.59 (95{\%} CI 1.42-1.78) per 100,000 per year. The Brighton criteria level 1-3 of diagnostic certainty was met in 279 (93{\%}) of the patients. Thirty-five percent of the patients were mildly affected (GBS disability score < 3) and a correlation between high age and high disability score at nadir was found (Spearman's rank correlation coefficient 0.42, p < 0.0001). The group of 89 (30{\%}) patients who were enrolled in IGOS had higher GBS disability score at nadir, were admitted 5 days earlier, reached nadir 4 days faster, and a larger proportion received treatment with IVIg (all p < 0.05).CONCLUSION: The epidemiology and full clinical spectrum of GBS are described in a population-based study. This includes a larger proportion of milder cases that are underrepresented in prospective cohorts such as IGOS.",
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Al-Hakem, H, Sindrup, SH, Andersen, H, de la Cour, CD, Lassen, LL, van den Berg, B, Jacobs, BC & Harbo, T 2019, 'Guillain–Barré syndrome in Denmark: a population-based study on epidemiology, diagnosis and clinical severity', Journal of Neurology, bind 266, nr. 2, s. 440–449. https://doi.org/10.1007/s00415-018-9151-x

Guillain–Barré syndrome in Denmark : a population-based study on epidemiology, diagnosis and clinical severity. / Al-Hakem, Helle; Sindrup, Søren H.; Andersen, Henning; de la Cour, Charlotte Dornonville; Lassen, Lisbeth L.; van den Berg, Bianca; Jacobs, Bart C.; Harbo, Thomas.

I: Journal of Neurology, Bind 266, Nr. 2, 02.2019, s. 440–449.

Publikation: Bidrag til tidsskriftLetterForskningpeer review

TY - JOUR

T1 - Guillain–Barré syndrome in Denmark

T2 - a population-based study on epidemiology, diagnosis and clinical severity

AU - Al-Hakem, Helle

AU - Sindrup, Søren H.

AU - Andersen, Henning

AU - de la Cour, Charlotte Dornonville

AU - Lassen, Lisbeth L.

AU - van den Berg, Bianca

AU - Jacobs, Bart C.

AU - Harbo, Thomas

PY - 2019/2

Y1 - 2019/2

N2 - OBJECTIVES: To describe the epidemiology and clinical heterogeneity of Guillain-Barré syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS).METHODS: The incidence rate (IR) of GBS in Denmark from September 2012 to December 2015, applying the National Institute of Neurological Disorders and Stroke (NINDS) diagnostic criteria, was estimated and the level of diagnostic certainty was described with the Brighton criteria. All cases registered with a diagnosis of GBS or other inflammatory neuropathies in the Danish National Hospital Registry were reviewed for diagnostic criteria and for information on treatment and clinical course.RESULTS: A total of 299 GBS cases were confirmed, corresponding to a crude IR of 1.59 (95% CI 1.42-1.78) per 100,000 per year. The Brighton criteria level 1-3 of diagnostic certainty was met in 279 (93%) of the patients. Thirty-five percent of the patients were mildly affected (GBS disability score < 3) and a correlation between high age and high disability score at nadir was found (Spearman's rank correlation coefficient 0.42, p < 0.0001). The group of 89 (30%) patients who were enrolled in IGOS had higher GBS disability score at nadir, were admitted 5 days earlier, reached nadir 4 days faster, and a larger proportion received treatment with IVIg (all p < 0.05).CONCLUSION: The epidemiology and full clinical spectrum of GBS are described in a population-based study. This includes a larger proportion of milder cases that are underrepresented in prospective cohorts such as IGOS.

AB - OBJECTIVES: To describe the epidemiology and clinical heterogeneity of Guillain-Barré syndrome (GBS) in Denmark and to compare a population-based cohort to prospectively included patients in the International GBS Outcome Study (IGOS).METHODS: The incidence rate (IR) of GBS in Denmark from September 2012 to December 2015, applying the National Institute of Neurological Disorders and Stroke (NINDS) diagnostic criteria, was estimated and the level of diagnostic certainty was described with the Brighton criteria. All cases registered with a diagnosis of GBS or other inflammatory neuropathies in the Danish National Hospital Registry were reviewed for diagnostic criteria and for information on treatment and clinical course.RESULTS: A total of 299 GBS cases were confirmed, corresponding to a crude IR of 1.59 (95% CI 1.42-1.78) per 100,000 per year. The Brighton criteria level 1-3 of diagnostic certainty was met in 279 (93%) of the patients. Thirty-five percent of the patients were mildly affected (GBS disability score < 3) and a correlation between high age and high disability score at nadir was found (Spearman's rank correlation coefficient 0.42, p < 0.0001). The group of 89 (30%) patients who were enrolled in IGOS had higher GBS disability score at nadir, were admitted 5 days earlier, reached nadir 4 days faster, and a larger proportion received treatment with IVIg (all p < 0.05).CONCLUSION: The epidemiology and full clinical spectrum of GBS are described in a population-based study. This includes a larger proportion of milder cases that are underrepresented in prospective cohorts such as IGOS.

KW - Brighton criteria

KW - Epidemiology

KW - Guillain–Barré syndrome

KW - IGOS

KW - International GBS outcome study

U2 - 10.1007/s00415-018-9151-x

DO - 10.1007/s00415-018-9151-x

M3 - Letter

VL - 266

SP - 440

EP - 449

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 2

ER -