Guideline for stress ulcer prophylaxis in the intensive care unit

Kristian Rørbaek Madsen, Kristian Lorentzen, Niels Clausen, Emilie Oberg, Peter Roy Casparij Kirkegaard, Nana Maymann-Holler, Morten Hylander Møller

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Stress ulcer prophylaxis (SUP) is commonly used in the intensive care unit (ICU), and is recommended in the Surviving Sepsis Campaign guidelines 2012. The present guideline from the Danish Society of Intensive Care Medicine and the Danish Society of Anesthesiology and Intensive Care Medicine sums up current evidence and gives clinical recommendations for SUP in the ICU. The GRADE approach was used for grading the evidence (www.gradeworkinggroup.org). In conclusion, existing meta-analyses have been underpowered to reach firm conclusions. We recommend not using SUP routinely for adult critically ill patients in the ICU outside the context of randomized controlled trials (GRADE 1C). No robust evidence supports recommendations for subpopulations in the ICU such as septic, burn, trauma, cardiothoracic or enterally fed patients. However, if SUP is considered clinically indicated in individual patients, we suggest using proton pump inhibitors over histamine-2-receptor antagonists (GRADE 2C).

OriginalsprogEngelsk
TidsskriftDanish Medical Journal
Vol/bind61
Udgave nummer3
Sider (fra-til)C4811
ISSN2245-1919
StatusUdgivet - mar. 2014

Fingeraftryk

Ulcer
Intensive Care Units
Guidelines
Medicine
Histamine Receptors
Critical Illness
Meta-Analysis
Randomized Controlled Trials
Wounds and Injuries

Citer dette

Madsen, K. R., Lorentzen, K., Clausen, N., Oberg, E., Kirkegaard, P. R. C., Maymann-Holler, N., & Møller, M. H. (2014). Guideline for stress ulcer prophylaxis in the intensive care unit. Danish Medical Journal, 61(3), C4811.
Madsen, Kristian Rørbaek ; Lorentzen, Kristian ; Clausen, Niels ; Oberg, Emilie ; Kirkegaard, Peter Roy Casparij ; Maymann-Holler, Nana ; Møller, Morten Hylander. / Guideline for stress ulcer prophylaxis in the intensive care unit. I: Danish Medical Journal. 2014 ; Bind 61, Nr. 3. s. C4811.
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abstract = "Stress ulcer prophylaxis (SUP) is commonly used in the intensive care unit (ICU), and is recommended in the Surviving Sepsis Campaign guidelines 2012. The present guideline from the Danish Society of Intensive Care Medicine and the Danish Society of Anesthesiology and Intensive Care Medicine sums up current evidence and gives clinical recommendations for SUP in the ICU. The GRADE approach was used for grading the evidence (www.gradeworkinggroup.org). In conclusion, existing meta-analyses have been underpowered to reach firm conclusions. We recommend not using SUP routinely for adult critically ill patients in the ICU outside the context of randomized controlled trials (GRADE 1C). No robust evidence supports recommendations for subpopulations in the ICU such as septic, burn, trauma, cardiothoracic or enterally fed patients. However, if SUP is considered clinically indicated in individual patients, we suggest using proton pump inhibitors over histamine-2-receptor antagonists (GRADE 2C).",
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Madsen, KR, Lorentzen, K, Clausen, N, Oberg, E, Kirkegaard, PRC, Maymann-Holler, N & Møller, MH 2014, 'Guideline for stress ulcer prophylaxis in the intensive care unit', Danish Medical Journal, bind 61, nr. 3, s. C4811.

Guideline for stress ulcer prophylaxis in the intensive care unit. / Madsen, Kristian Rørbaek; Lorentzen, Kristian; Clausen, Niels; Oberg, Emilie; Kirkegaard, Peter Roy Casparij; Maymann-Holler, Nana; Møller, Morten Hylander.

I: Danish Medical Journal, Bind 61, Nr. 3, 03.2014, s. C4811.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Guideline for stress ulcer prophylaxis in the intensive care unit

AU - Madsen, Kristian Rørbaek

AU - Lorentzen, Kristian

AU - Clausen, Niels

AU - Oberg, Emilie

AU - Kirkegaard, Peter Roy Casparij

AU - Maymann-Holler, Nana

AU - Møller, Morten Hylander

PY - 2014/3

Y1 - 2014/3

N2 - Stress ulcer prophylaxis (SUP) is commonly used in the intensive care unit (ICU), and is recommended in the Surviving Sepsis Campaign guidelines 2012. The present guideline from the Danish Society of Intensive Care Medicine and the Danish Society of Anesthesiology and Intensive Care Medicine sums up current evidence and gives clinical recommendations for SUP in the ICU. The GRADE approach was used for grading the evidence (www.gradeworkinggroup.org). In conclusion, existing meta-analyses have been underpowered to reach firm conclusions. We recommend not using SUP routinely for adult critically ill patients in the ICU outside the context of randomized controlled trials (GRADE 1C). No robust evidence supports recommendations for subpopulations in the ICU such as septic, burn, trauma, cardiothoracic or enterally fed patients. However, if SUP is considered clinically indicated in individual patients, we suggest using proton pump inhibitors over histamine-2-receptor antagonists (GRADE 2C).

AB - Stress ulcer prophylaxis (SUP) is commonly used in the intensive care unit (ICU), and is recommended in the Surviving Sepsis Campaign guidelines 2012. The present guideline from the Danish Society of Intensive Care Medicine and the Danish Society of Anesthesiology and Intensive Care Medicine sums up current evidence and gives clinical recommendations for SUP in the ICU. The GRADE approach was used for grading the evidence (www.gradeworkinggroup.org). In conclusion, existing meta-analyses have been underpowered to reach firm conclusions. We recommend not using SUP routinely for adult critically ill patients in the ICU outside the context of randomized controlled trials (GRADE 1C). No robust evidence supports recommendations for subpopulations in the ICU such as septic, burn, trauma, cardiothoracic or enterally fed patients. However, if SUP is considered clinically indicated in individual patients, we suggest using proton pump inhibitors over histamine-2-receptor antagonists (GRADE 2C).

M3 - Journal article

VL - 61

SP - C4811

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 1603-9629

IS - 3

ER -

Madsen KR, Lorentzen K, Clausen N, Oberg E, Kirkegaard PRC, Maymann-Holler N et al. Guideline for stress ulcer prophylaxis in the intensive care unit. Danish Medical Journal. 2014 mar;61(3):C4811.