Greater Perceived Physical Fatigability Is Associated with Lower Cognition: The Long Life Family Study

Theresa Gmelin, Andrea Rosso, Stacy Andersen, Stephanie Cosentino, Mary Wojczynski, Kaare Christensen, Robert Boudreau, Nancy Glynn

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Greater perceived physical fatigability is associated with physical functional decline, but few studies have examined its relation with cognition. Adults ≥60 (mean±SD age 73.7±10.5, 54.7\ 99.6\ from the Long Life Family Study (n=2355) completed the Pittsburgh Fatigability Scale (PFS, 0-50, higher=greater fatigability) and a neurocognitive examination. Generalized estimating equations were used to account for family structure. Covariates included age, sex, field center, depressive symptoms (Center for Epidemiological Studies-Depression), education, and self-reported health. Each 1-point greater PFS was associated with lower: (1) global cognition (Mini-Mental Status Exam; β=-0.36,p\lt;.0001), (2) verbal fluency (phonemic: β=-0.09,p=.029 and semantic: β=-0.14,p\lt;.0001), (3) memory (Hopkins Verbal Learning Test-Revised: β=-0.06,p=.037), and (4) psychomotor speed (Digit Symbol Substitution Test: β=-0.10,p\lt;.0001), after covariate adjustment. Greater perceived physical fatigability was significantly associated with lower memory and cognitive function in older adults, and may represent a promising new biomarker of biological aging reflecting declining brain reserve, resilience, and neurodegeneration.
TidsskriftInnovation in Aging
Udgave nummerSuppl. 1
Sider (fra-til)782-783
Antal sider2
StatusUdgivet - 2020
BegivenhedGSA 2020 Annual Scientific Meeting Online -
Varighed: 4. nov. 20207. nov. 2020


KonferenceGSA 2020 Annual Scientific Meeting Online