Graphene oxide linking layers for highly sensitive SPR biosensing of small molecules

Aleksey V. Arsenin, Yu V. Stebunov, Valentyn S. Volkov

Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review

Resumé

The development of graphene oxide (GO) interfaces can significantly improve the performance of modern surface plasmon resonance (SPR) biosensors. GO linking layers have high binding capacity for a wide range of chemical and biological ligands owing to large surface area of GO and its unique biochemical properties. Here, we compared binding capacities of GO linking layers with different thicknesses and widely-used hydrogel linking layers based on carboxymethylated dextran (CMD). SPR measurements corresponding to the activation of carboxyl groups on the surface of SPR chips showed that the binding capacity of a 50-nm-thick GO linking layer is 30-times higher than for 150-nm-thick CMD layer, which results in enhanced biosensing sensitivity of GO chips and can lead to novel applications for SPR biosensing.
OriginalsprogEngelsk
TidsskriftMaterials Today: Proceedings
Vol/bind5
Udgave nummer9
Sider (fra-til)17437-17441
ISSN2214-7853
DOI
StatusUdgivet - 29. aug. 2018
Begivenhed9th International Conference on Advanced Nano Materials - University of Aveiro, Portugal
Varighed: 19. jul. 201721. jul. 2017

Konference

Konference9th International Conference on Advanced Nano Materials
LokationUniversity of Aveiro
LandPortugal
Periode19/07/201721/07/2017

Fingeraftryk

Graphite
Surface plasmon resonance
Oxides
Molecules
Dextrans
Hydrogel
Biosensors
Chemical activation
Ligands

Citer dette

Arsenin, Aleksey V. ; Stebunov, Yu V. ; Volkov, Valentyn S. / Graphene oxide linking layers for highly sensitive SPR biosensing of small molecules. I: Materials Today: Proceedings. 2018 ; Bind 5, Nr. 9. s. 17437-17441.
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abstract = "The development of graphene oxide (GO) interfaces can significantly improve the performance of modern surface plasmon resonance (SPR) biosensors. GO linking layers have high binding capacity for a wide range of chemical and biological ligands owing to large surface area of GO and its unique biochemical properties. Here, we compared binding capacities of GO linking layers with different thicknesses and widely-used hydrogel linking layers based on carboxymethylated dextran (CMD). SPR measurements corresponding to the activation of carboxyl groups on the surface of SPR chips showed that the binding capacity of a 50-nm-thick GO linking layer is 30-times higher than for 150-nm-thick CMD layer, which results in enhanced biosensing sensitivity of GO chips and can lead to novel applications for SPR biosensing.",
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Graphene oxide linking layers for highly sensitive SPR biosensing of small molecules. / Arsenin, Aleksey V. ; Stebunov, Yu V.; Volkov, Valentyn S.

I: Materials Today: Proceedings, Bind 5, Nr. 9, 29.08.2018, s. 17437-17441.

Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review

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AU - Arsenin, Aleksey V.

AU - Stebunov, Yu V.

AU - Volkov, Valentyn S.

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Y1 - 2018/8/29

N2 - The development of graphene oxide (GO) interfaces can significantly improve the performance of modern surface plasmon resonance (SPR) biosensors. GO linking layers have high binding capacity for a wide range of chemical and biological ligands owing to large surface area of GO and its unique biochemical properties. Here, we compared binding capacities of GO linking layers with different thicknesses and widely-used hydrogel linking layers based on carboxymethylated dextran (CMD). SPR measurements corresponding to the activation of carboxyl groups on the surface of SPR chips showed that the binding capacity of a 50-nm-thick GO linking layer is 30-times higher than for 150-nm-thick CMD layer, which results in enhanced biosensing sensitivity of GO chips and can lead to novel applications for SPR biosensing.

AB - The development of graphene oxide (GO) interfaces can significantly improve the performance of modern surface plasmon resonance (SPR) biosensors. GO linking layers have high binding capacity for a wide range of chemical and biological ligands owing to large surface area of GO and its unique biochemical properties. Here, we compared binding capacities of GO linking layers with different thicknesses and widely-used hydrogel linking layers based on carboxymethylated dextran (CMD). SPR measurements corresponding to the activation of carboxyl groups on the surface of SPR chips showed that the binding capacity of a 50-nm-thick GO linking layer is 30-times higher than for 150-nm-thick CMD layer, which results in enhanced biosensing sensitivity of GO chips and can lead to novel applications for SPR biosensing.

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