Gestational Diabetes Mellitus

Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVE To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort. RESEARCH DESIGN AND METHODS This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria. FVPG measured at 28 weeks’ gestation was related to pregnancy outcomes. RESULTS With use of the World Health Organization (WHO) 2013 threshold of FVPG ‡5.1 mmol/L, 40.1% of the cohort qualified as having GDM. There was no evidence of excess fetal growth, hypertension in pregnancy, or cesarean delivery in women with FVPG <5.6 mmol/L. CONCLUSIONS The WHO 2013 FVPG threshold for GDM is unsuitable for Denmark. It inappropriately labels as having GDM an unmanageably large number of women who are at low absolute risk of pregnancy complications.

OriginalsprogEngelsk
TidsskriftDiabetes Care
Vol/bind41
Udgave nummer7
Sider (fra-til)1339-1342
ISSN0149-5992
DOI
StatusUdgivet - jul. 2018

Fingeraftryk

Gestational Diabetes
Fasting
Pregnancy Complications
Denmark
Cohort Studies

Citer dette

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title = "Gestational Diabetes Mellitus: Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds",
abstract = "OBJECTIVE To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort. RESEARCH DESIGN AND METHODS This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria. FVPG measured at 28 weeks’ gestation was related to pregnancy outcomes. RESULTS With use of the World Health Organization (WHO) 2013 threshold of FVPG ‡5.1 mmol/L, 40.1{\%} of the cohort qualified as having GDM. There was no evidence of excess fetal growth, hypertension in pregnancy, or cesarean delivery in women with FVPG <5.6 mmol/L. CONCLUSIONS The WHO 2013 FVPG threshold for GDM is unsuitable for Denmark. It inappropriately labels as having GDM an unmanageably large number of women who are at low absolute risk of pregnancy complications.",
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author = "McIntyre, {H. David} and Jensen, {Dorte M} and Jensen, {Richard C.} and Kyhl, {Henriette B} and Jensen, {Tina K.} and Dorte Glintborg and Marianne Andersen",
note = "{\circledC} 2018 by the American Diabetes Association.",
year = "2018",
month = "7",
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language = "English",
volume = "41",
pages = "1339--1342",
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Gestational Diabetes Mellitus : Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds. / McIntyre, H. David; Jensen, Dorte M; Jensen, Richard C.; Kyhl, Henriette B; Jensen, Tina K.; Glintborg, Dorte; Andersen, Marianne.

I: Diabetes Care, Bind 41, Nr. 7, 07.2018, s. 1339-1342.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Gestational Diabetes Mellitus

T2 - Does One Size Fit All? A Challenge to Uniform Worldwide Diagnostic Thresholds

AU - McIntyre, H. David

AU - Jensen, Dorte M

AU - Jensen, Richard C.

AU - Kyhl, Henriette B

AU - Jensen, Tina K.

AU - Glintborg, Dorte

AU - Andersen, Marianne

N1 - © 2018 by the American Diabetes Association.

PY - 2018/7

Y1 - 2018/7

N2 - OBJECTIVE To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort. RESEARCH DESIGN AND METHODS This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria. FVPG measured at 28 weeks’ gestation was related to pregnancy outcomes. RESULTS With use of the World Health Organization (WHO) 2013 threshold of FVPG ‡5.1 mmol/L, 40.1% of the cohort qualified as having GDM. There was no evidence of excess fetal growth, hypertension in pregnancy, or cesarean delivery in women with FVPG <5.6 mmol/L. CONCLUSIONS The WHO 2013 FVPG threshold for GDM is unsuitable for Denmark. It inappropriately labels as having GDM an unmanageably large number of women who are at low absolute risk of pregnancy complications.

AB - OBJECTIVE To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort. RESEARCH DESIGN AND METHODS This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria. FVPG measured at 28 weeks’ gestation was related to pregnancy outcomes. RESULTS With use of the World Health Organization (WHO) 2013 threshold of FVPG ‡5.1 mmol/L, 40.1% of the cohort qualified as having GDM. There was no evidence of excess fetal growth, hypertension in pregnancy, or cesarean delivery in women with FVPG <5.6 mmol/L. CONCLUSIONS The WHO 2013 FVPG threshold for GDM is unsuitable for Denmark. It inappropriately labels as having GDM an unmanageably large number of women who are at low absolute risk of pregnancy complications.

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KW - Cesarean Section/statistics & numerical data

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KW - Fasting/blood

KW - Female

KW - Glucose Tolerance Test/standards

KW - Humans

KW - Infant, Newborn

KW - Infant, Newborn, Diseases/epidemiology

KW - Pregnancy

KW - Pregnancy Complications/epidemiology

KW - Pregnancy Outcome/epidemiology

KW - Prevalence

KW - Reference Values

U2 - 10.2337/dc17-2393

DO - 10.2337/dc17-2393

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SN - 0149-5992

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ER -