@article{b429c1a0cc2311dd9906000ea68e967b,
title = "Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevitY: Role of CYP2D6 and CYP2C19 in longevity",
abstract = "OBJECTIVE: To test whether some genotypes for CYP2D6 or CYP2C19 could contribute to longevity, we genotyped 241 Danish nonagenarians and centenarians for CYP2D6 and CYP2C19. METHODS: For CYP2D6 we identified the alleles CYP2D6*1, CYP2D6*3 and CYP2D6*4 with allele-specific polymerase chain reaction (PCR). The CYP2D6*5 alleles were identified with a long PCR method. For CYP2C19 we identified the alleles CYP2C19*1, CYP2C19*2 and CYP2C19*3 with an oligonucleotide ligation assay. RESULTS: The four alleles for CYP2D6 did not occur in Hardy-Weinberg proportions. The frequency of poor metabolism was slightly higher (10.2\%) than expected [7.7\%; odds ratio (OR) = 1.36 (0.75-2.40)]. The genotypes for CYP2C19 occur in Hardy-Weinberg proportions. The frequency of poor metabolism (3.8\%) was not significantly different from a young control group [3.1\%; OR = 1.21 (0.26-5.75)]. CONCLUSION: CYP2D6 could play a role in human longevity due to the lack of Hardy-Weinberg proportions. If CYP2D6 only plays a role in longevity by protecting the poor metabolizers from cancer, we should expect a rise in the frequency in these genotypes in Denmark from 7.7\% among young adults to 10-11\% among very old people. We found a frequency of poor metabolism of 10.2\% in the very old group. CYP2C19 is - due to the occurrence of Hardy-Weinberg proportions and the expected number of poor metabolizers unlikely to contribute to human longevity.",
keywords = "Adult, Aged, Aged, 80 and over, Aging, Alleles, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2D6, Cytochrome P-450 Enzyme System, DNA, Female, Genotype, Humans, Longevity, Male, Middle Aged, Mixed Function Oxygenases",
author = "L Bathum and K Andersen-Ranberg and J Boldsen and K Br{\o}sen and B Jeune",
year = "1998",
month = jul,
day = "1",
doi = "10.1007/s002280050487",
language = "English",
volume = "54",
pages = "427--430",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer Science+Business Media",
number = "5",
}