Genome organization and expression of the rat ACBP gene family

S Mandrup, P H Andreasen, J Knudsen, K Kristiansen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: null-null
OriginalsprogEngelsk
TidsskriftMolecular and Cellular Biochemistry
Vol/bind123
Udgave nummer1-2
Sider (fra-til)55-61
Antal sider6
ISSN0300-8177
DOI
StatusUdgivet - 1993

Fingeraftryk

Diazepam Binding Inhibitor
Rats
Genes
Acyl Coenzyme A
Genetic Promoter Regions
Esters
Computer aided analysis
Pseudogenes
Essential Genes
Ports and harbors
Protein Binding
Tissue

Citer dette

Mandrup, S ; Andreasen, P H ; Knudsen, J ; Kristiansen, K. / Genome organization and expression of the rat ACBP gene family. I: Molecular and Cellular Biochemistry. 1993 ; Bind 123, Nr. 1-2. s. 55-61.
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title = "Genome organization and expression of the rat ACBP gene family",
abstract = "Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.",
keywords = "Acyl Coenzyme A, Animals, Base Sequence, Carrier Proteins, Cloning, Molecular, DNA, Diazepam Binding Inhibitor, Gene Expression, Genome, Molecular Sequence Data, Multigene Family, Promoter Regions, Genetic, Pseudogenes, Rats, Rats, Sprague-Dawley, Sequence Alignment",
author = "S Mandrup and Andreasen, {P H} and J Knudsen and K Kristiansen",
year = "1993",
doi = "10.1007/BF01076475",
language = "English",
volume = "123",
pages = "55--61",
journal = "Molecular and Cellular Biochemistry",
issn = "0300-8177",
publisher = "Springer",
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Genome organization and expression of the rat ACBP gene family. / Mandrup, S; Andreasen, P H; Knudsen, J; Kristiansen, K.

I: Molecular and Cellular Biochemistry, Bind 123, Nr. 1-2, 1993, s. 55-61.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Genome organization and expression of the rat ACBP gene family

AU - Mandrup, S

AU - Andreasen, P H

AU - Knudsen, J

AU - Kristiansen, K

PY - 1993

Y1 - 1993

N2 - Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.

AB - Acyl-CoA-Binding Protein (ACBP)/Diazepam-Binding Inhibitor (DBI) is a 10 kD protein which has been implicated in a surprisingly large number of biochemical functions. We have unambiguously demonstrated that ACBP binds acyl-CoA esters with high affinity and in vivo functions as an acyl-CoA ester pool former. We have molecularly cloned and characterized the rat ACBP gene family which comprises one expressed and four processed pseudogenes. One of these was shown to exist in two allelic forms. A comprehensive computer-aided analysis of the promoter region of the expressed ACBP gene revealed that it exhibits all the hallmarks of typical housekeeping genes. In addition, the promoter region harbors a number of potential tissue specific cis-acting elements that may in part regulate the level of ACBP expression in specialized cells.

KW - Acyl Coenzyme A

KW - Animals

KW - Base Sequence

KW - Carrier Proteins

KW - Cloning, Molecular

KW - DNA

KW - Diazepam Binding Inhibitor

KW - Gene Expression

KW - Genome

KW - Molecular Sequence Data

KW - Multigene Family

KW - Promoter Regions, Genetic

KW - Pseudogenes

KW - Rats

KW - Rats, Sprague-Dawley

KW - Sequence Alignment

U2 - 10.1007/BF01076475

DO - 10.1007/BF01076475

M3 - Journal article

VL - 123

SP - 55

EP - 61

JO - Molecular and Cellular Biochemistry

JF - Molecular and Cellular Biochemistry

SN - 0300-8177

IS - 1-2

ER -