Genetic susceptibility factors for multiple chemical sensitivity revisited

Nikolaj Drimer Berg, Henrik Berg Rasmussen, Allan Linneberg, Charlotte Brasch-Andersen, Mogens Fenger, Asger Dirksen, Søren Vesterhauge, Thomas Werge, Jesper Elberling

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: Mar
OriginalsprogEngelsk
TidsskriftInternational Journal of Hygiene and Environmental Health
Vol/bind213
Udgave nummer2
Sider (fra-til)131-139
Antal sider8
ISSN1438-4639
DOI
StatusUdgivet - 1. mar. 2010

Fingeraftryk

Multiple Chemical Sensitivity
Cholecystokinin B Receptor
Aryldialkylphosphatase
Cytochrome P-450 CYP2D6
Population
Alleles
Gene-Environment Interaction
Genetic Heterogeneity
Xenobiotics

Bibliografisk note

Copyright © 2010 Elsevier GmbH. All rights reserved.

Citer dette

Berg, Nikolaj Drimer ; Berg Rasmussen, Henrik ; Linneberg, Allan ; Brasch-Andersen, Charlotte ; Fenger, Mogens ; Dirksen, Asger ; Vesterhauge, Søren ; Werge, Thomas ; Elberling, Jesper. / Genetic susceptibility factors for multiple chemical sensitivity revisited. I: International Journal of Hygiene and Environmental Health. 2010 ; Bind 213, Nr. 2. s. 131-139.
@article{a67ce8f0303811dfba21000ea68e967b,
title = "Genetic susceptibility factors for multiple chemical sensitivity revisited",
abstract = "Multiple chemical sensitivity (MCS) is characterised by adverse effects due to exposure to low levels of chemical substances. Various genes, especially genes of importance to the metabolism of xenobiotic compounds, have been associated with MCS, but findings are inconsistent. The purpose of this study was to investigate genetic susceptibility factors for MCS and self-reported chemical sensitivity in a population sample. Ninety six MCS patients and 1,207 controls from a general population divided into four severity groups of chemical sensitivity were genotyped for variants in the genes encoding cytochrome P450 2D6, arylamine N-acetyltransferase 2, paraoxonase 1, methylene tetrahydrofolate reductase, and the cholecystokinin 2 receptor. No hypotheses were consistently confirmed. An apparent association between number of active cytochrome P450 2D6 alleles and MCS status was not statistically significant (OR=1.2, p=0.28). Fast arylamine N-acetyltransferase 2 metaboliser status was associated with severity of chemical sensitivity only in the most severely affected group in the population sample (OR=3.1, p=0.04). The cholecystokinin 2 receptor allele with 21 CT repeats was associated with MCS when compared in post hoc analyses with all individuals from the population sample (p=0.02). Genetic variants in paraoxonase 1 and methylene tetrahydrofolate reductase were not associated with MSC or with self-reported chemical sensitivity in the population sample. Our results suggest that variants in the genes examined are of less importance to MCS than previously reported or that gene-environment interactions or significant degrees of genetic heterogeneity in MCS underlie inconsistent findings in the literature.",
author = "Berg, {Nikolaj Drimer} and {Berg Rasmussen}, Henrik and Allan Linneberg and Charlotte Brasch-Andersen and Mogens Fenger and Asger Dirksen and S{\o}ren Vesterhauge and Thomas Werge and Jesper Elberling",
note = "Copyright {\circledC} 2010 Elsevier GmbH. All rights reserved.",
year = "2010",
month = "3",
day = "1",
doi = "10.1016/j.ijheh.2010.02.001",
language = "English",
volume = "213",
pages = "131--139",
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Berg, ND, Berg Rasmussen, H, Linneberg, A, Brasch-Andersen, C, Fenger, M, Dirksen, A, Vesterhauge, S, Werge, T & Elberling, J 2010, 'Genetic susceptibility factors for multiple chemical sensitivity revisited', International Journal of Hygiene and Environmental Health, bind 213, nr. 2, s. 131-139. https://doi.org/10.1016/j.ijheh.2010.02.001

Genetic susceptibility factors for multiple chemical sensitivity revisited. / Berg, Nikolaj Drimer; Berg Rasmussen, Henrik; Linneberg, Allan; Brasch-Andersen, Charlotte; Fenger, Mogens; Dirksen, Asger; Vesterhauge, Søren; Werge, Thomas; Elberling, Jesper.

I: International Journal of Hygiene and Environmental Health, Bind 213, Nr. 2, 01.03.2010, s. 131-139.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Genetic susceptibility factors for multiple chemical sensitivity revisited

AU - Berg, Nikolaj Drimer

AU - Berg Rasmussen, Henrik

AU - Linneberg, Allan

AU - Brasch-Andersen, Charlotte

AU - Fenger, Mogens

AU - Dirksen, Asger

AU - Vesterhauge, Søren

AU - Werge, Thomas

AU - Elberling, Jesper

N1 - Copyright © 2010 Elsevier GmbH. All rights reserved.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Multiple chemical sensitivity (MCS) is characterised by adverse effects due to exposure to low levels of chemical substances. Various genes, especially genes of importance to the metabolism of xenobiotic compounds, have been associated with MCS, but findings are inconsistent. The purpose of this study was to investigate genetic susceptibility factors for MCS and self-reported chemical sensitivity in a population sample. Ninety six MCS patients and 1,207 controls from a general population divided into four severity groups of chemical sensitivity were genotyped for variants in the genes encoding cytochrome P450 2D6, arylamine N-acetyltransferase 2, paraoxonase 1, methylene tetrahydrofolate reductase, and the cholecystokinin 2 receptor. No hypotheses were consistently confirmed. An apparent association between number of active cytochrome P450 2D6 alleles and MCS status was not statistically significant (OR=1.2, p=0.28). Fast arylamine N-acetyltransferase 2 metaboliser status was associated with severity of chemical sensitivity only in the most severely affected group in the population sample (OR=3.1, p=0.04). The cholecystokinin 2 receptor allele with 21 CT repeats was associated with MCS when compared in post hoc analyses with all individuals from the population sample (p=0.02). Genetic variants in paraoxonase 1 and methylene tetrahydrofolate reductase were not associated with MSC or with self-reported chemical sensitivity in the population sample. Our results suggest that variants in the genes examined are of less importance to MCS than previously reported or that gene-environment interactions or significant degrees of genetic heterogeneity in MCS underlie inconsistent findings in the literature.

AB - Multiple chemical sensitivity (MCS) is characterised by adverse effects due to exposure to low levels of chemical substances. Various genes, especially genes of importance to the metabolism of xenobiotic compounds, have been associated with MCS, but findings are inconsistent. The purpose of this study was to investigate genetic susceptibility factors for MCS and self-reported chemical sensitivity in a population sample. Ninety six MCS patients and 1,207 controls from a general population divided into four severity groups of chemical sensitivity were genotyped for variants in the genes encoding cytochrome P450 2D6, arylamine N-acetyltransferase 2, paraoxonase 1, methylene tetrahydrofolate reductase, and the cholecystokinin 2 receptor. No hypotheses were consistently confirmed. An apparent association between number of active cytochrome P450 2D6 alleles and MCS status was not statistically significant (OR=1.2, p=0.28). Fast arylamine N-acetyltransferase 2 metaboliser status was associated with severity of chemical sensitivity only in the most severely affected group in the population sample (OR=3.1, p=0.04). The cholecystokinin 2 receptor allele with 21 CT repeats was associated with MCS when compared in post hoc analyses with all individuals from the population sample (p=0.02). Genetic variants in paraoxonase 1 and methylene tetrahydrofolate reductase were not associated with MSC or with self-reported chemical sensitivity in the population sample. Our results suggest that variants in the genes examined are of less importance to MCS than previously reported or that gene-environment interactions or significant degrees of genetic heterogeneity in MCS underlie inconsistent findings in the literature.

U2 - 10.1016/j.ijheh.2010.02.001

DO - 10.1016/j.ijheh.2010.02.001

M3 - Journal article

C2 - 20185366

VL - 213

SP - 131

EP - 139

JO - International Journal of Hygiene and Environmental Health

JF - International Journal of Hygiene and Environmental Health

SN - 1438-4639

IS - 2

ER -