Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis

Nikolai Dyrberg Loft, Lone Skov, Mads Kirchheiner Rasmussen, Robert Gniadecki, Tomas Norman Dam, Ivan Brandslund, Hans Jürgen Hoffmann, Malene Rohr Andersen, Ram Benny Dessau, Ann Christina Bergmann, Niels Møller Andersen, Mikkel Kramme Abildtoft, Paal Skytt Andersen, Merete Lund Hetland, Bente Glintborg, Steffen Bank, Ulla Vogel, Vibeke Andersen

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Resumé

BACKGROUND: Psoriasis (PsO) is a chronic inflammatory disease with predominantly cutaneous manifestations. Approximately one third of patients with PsO develop psoriatic arthritis (PsA), whereas the remaining proportion of patients has isolated cutaneous psoriasis (PsC). These two phenotypes share common immunology, but with different heredity that might in part be explained by genetic variables.

METHODS: Using a candidate gene approach, we studied 53 single nucleotide polymorphisms (SNPs) in 37 genes that regulate inflammation. In total, we assessed 480 patients with PsO from DERMBIO, of whom 151 had PsC for 10 years or more (PsC10), 459 patients with PsA from DANBIO, and 795 healthy controls. Using logistic regression analysis, crude and adjusted for age and gender, we assessed associations between genetic variants and PsO, PsC10, and PsA, as well as associations between genetic variants and development of PsA in PsO.

RESULTS: Eleven polymorphisms in 10 genes were nominally associated with PsO and/or PsC and/or PsA (P < 0.05). After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.

CONCLUSION: Among a cohort of Danish patients with moderate-to-severe psoriasis, two SNPs in the IL12B and TNF genes were associated with susceptibility of psoriasis. None of the SNPs were specifically associated with isolated cutaneous psoriasis or psoriatic arthritis.

OriginalsprogEngelsk
Artikelnummere0192010
TidsskriftPLOS ONE
Vol/bind13
Udgave nummer2
Antal sider12
ISSN1932-6203
DOI
StatusUdgivet - 1. feb. 2018

Fingeraftryk

psoriasis
Psoriatic Arthritis
arthritis
Genetic Polymorphisms
Polymorphism
Psoriasis
genetic polymorphism
Nucleotides
Genes
single nucleotide polymorphism
Single Nucleotide Polymorphism
Immunology
Regression analysis
Logistics
genes
Testing
Skin
Heredity
Allergy and Immunology
immunology

Citer dette

Loft, Nikolai Dyrberg ; Skov, Lone ; Rasmussen, Mads Kirchheiner ; Gniadecki, Robert ; Dam, Tomas Norman ; Brandslund, Ivan ; Hoffmann, Hans Jürgen ; Andersen, Malene Rohr ; Dessau, Ram Benny ; Bergmann, Ann Christina ; Andersen, Niels Møller ; Abildtoft, Mikkel Kramme ; Andersen, Paal Skytt ; Hetland, Merete Lund ; Glintborg, Bente ; Bank, Steffen ; Vogel, Ulla ; Andersen, Vibeke. / Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis. I: PLOS ONE. 2018 ; Bind 13, Nr. 2.
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title = "Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis",
abstract = "BACKGROUND: Psoriasis (PsO) is a chronic inflammatory disease with predominantly cutaneous manifestations. Approximately one third of patients with PsO develop psoriatic arthritis (PsA), whereas the remaining proportion of patients has isolated cutaneous psoriasis (PsC). These two phenotypes share common immunology, but with different heredity that might in part be explained by genetic variables.METHODS: Using a candidate gene approach, we studied 53 single nucleotide polymorphisms (SNPs) in 37 genes that regulate inflammation. In total, we assessed 480 patients with PsO from DERMBIO, of whom 151 had PsC for 10 years or more (PsC10), 459 patients with PsA from DANBIO, and 795 healthy controls. Using logistic regression analysis, crude and adjusted for age and gender, we assessed associations between genetic variants and PsO, PsC10, and PsA, as well as associations between genetic variants and development of PsA in PsO.RESULTS: Eleven polymorphisms in 10 genes were nominally associated with PsO and/or PsC and/or PsA (P < 0.05). After correction for multiple testing with a false discovery rate of 5{\%}, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.CONCLUSION: Among a cohort of Danish patients with moderate-to-severe psoriasis, two SNPs in the IL12B and TNF genes were associated with susceptibility of psoriasis. None of the SNPs were specifically associated with isolated cutaneous psoriasis or psoriatic arthritis.",
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author = "Loft, {Nikolai Dyrberg} and Lone Skov and Rasmussen, {Mads Kirchheiner} and Robert Gniadecki and Dam, {Tomas Norman} and Ivan Brandslund and Hoffmann, {Hans J{\"u}rgen} and Andersen, {Malene Rohr} and Dessau, {Ram Benny} and Bergmann, {Ann Christina} and Andersen, {Niels M{\o}ller} and Abildtoft, {Mikkel Kramme} and Andersen, {Paal Skytt} and Hetland, {Merete Lund} and Bente Glintborg and Steffen Bank and Ulla Vogel and Vibeke Andersen",
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Loft, ND, Skov, L, Rasmussen, MK, Gniadecki, R, Dam, TN, Brandslund, I, Hoffmann, HJ, Andersen, MR, Dessau, RB, Bergmann, AC, Andersen, NM, Abildtoft, MK, Andersen, PS, Hetland, ML, Glintborg, B, Bank, S, Vogel, U & Andersen, V 2018, 'Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis', PLOS ONE, bind 13, nr. 2, e0192010. https://doi.org/10.1371/journal.pone.0192010

Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis. / Loft, Nikolai Dyrberg; Skov, Lone; Rasmussen, Mads Kirchheiner; Gniadecki, Robert; Dam, Tomas Norman; Brandslund, Ivan; Hoffmann, Hans Jürgen; Andersen, Malene Rohr; Dessau, Ram Benny; Bergmann, Ann Christina; Andersen, Niels Møller; Abildtoft, Mikkel Kramme; Andersen, Paal Skytt; Hetland, Merete Lund; Glintborg, Bente; Bank, Steffen; Vogel, Ulla; Andersen, Vibeke.

I: PLOS ONE, Bind 13, Nr. 2, e0192010, 01.02.2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Genetic polymorphisms associated with psoriasis and development of psoriatic arthritis in patients with psoriasis

AU - Loft, Nikolai Dyrberg

AU - Skov, Lone

AU - Rasmussen, Mads Kirchheiner

AU - Gniadecki, Robert

AU - Dam, Tomas Norman

AU - Brandslund, Ivan

AU - Hoffmann, Hans Jürgen

AU - Andersen, Malene Rohr

AU - Dessau, Ram Benny

AU - Bergmann, Ann Christina

AU - Andersen, Niels Møller

AU - Abildtoft, Mikkel Kramme

AU - Andersen, Paal Skytt

AU - Hetland, Merete Lund

AU - Glintborg, Bente

AU - Bank, Steffen

AU - Vogel, Ulla

AU - Andersen, Vibeke

PY - 2018/2/1

Y1 - 2018/2/1

N2 - BACKGROUND: Psoriasis (PsO) is a chronic inflammatory disease with predominantly cutaneous manifestations. Approximately one third of patients with PsO develop psoriatic arthritis (PsA), whereas the remaining proportion of patients has isolated cutaneous psoriasis (PsC). These two phenotypes share common immunology, but with different heredity that might in part be explained by genetic variables.METHODS: Using a candidate gene approach, we studied 53 single nucleotide polymorphisms (SNPs) in 37 genes that regulate inflammation. In total, we assessed 480 patients with PsO from DERMBIO, of whom 151 had PsC for 10 years or more (PsC10), 459 patients with PsA from DANBIO, and 795 healthy controls. Using logistic regression analysis, crude and adjusted for age and gender, we assessed associations between genetic variants and PsO, PsC10, and PsA, as well as associations between genetic variants and development of PsA in PsO.RESULTS: Eleven polymorphisms in 10 genes were nominally associated with PsO and/or PsC and/or PsA (P < 0.05). After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.CONCLUSION: Among a cohort of Danish patients with moderate-to-severe psoriasis, two SNPs in the IL12B and TNF genes were associated with susceptibility of psoriasis. None of the SNPs were specifically associated with isolated cutaneous psoriasis or psoriatic arthritis.

AB - BACKGROUND: Psoriasis (PsO) is a chronic inflammatory disease with predominantly cutaneous manifestations. Approximately one third of patients with PsO develop psoriatic arthritis (PsA), whereas the remaining proportion of patients has isolated cutaneous psoriasis (PsC). These two phenotypes share common immunology, but with different heredity that might in part be explained by genetic variables.METHODS: Using a candidate gene approach, we studied 53 single nucleotide polymorphisms (SNPs) in 37 genes that regulate inflammation. In total, we assessed 480 patients with PsO from DERMBIO, of whom 151 had PsC for 10 years or more (PsC10), 459 patients with PsA from DANBIO, and 795 healthy controls. Using logistic regression analysis, crude and adjusted for age and gender, we assessed associations between genetic variants and PsO, PsC10, and PsA, as well as associations between genetic variants and development of PsA in PsO.RESULTS: Eleven polymorphisms in 10 genes were nominally associated with PsO and/or PsC and/or PsA (P < 0.05). After correction for multiple testing with a false discovery rate of 5%, two SNPs remained significant: TNF (rs361525) was associated with PsO, PsC10, and PsA; and IL12B (rs6887695) was associated with PsO.CONCLUSION: Among a cohort of Danish patients with moderate-to-severe psoriasis, two SNPs in the IL12B and TNF genes were associated with susceptibility of psoriasis. None of the SNPs were specifically associated with isolated cutaneous psoriasis or psoriatic arthritis.

KW - Journal Article

U2 - 10.1371/journal.pone.0192010

DO - 10.1371/journal.pone.0192010

M3 - Journal article

VL - 13

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 2

M1 - e0192010

ER -