Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels

Kate Lykke Lambertsen, Jan Bert Gramsbergen, Mithula Sivasaravanaparan, Nicholas Ditzel, Linda Maria Sevelsted Møller, Aida Oliván-Viguera, Maj Rabjerg, Heike Wulff, Ralf Köhler

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Abstrakt

The calmodulin/calcium-activated K(+) channel KCa3.1 is expressed in red and white blood cells, epithelia and endothelia, and possibly central and peripheral neurons. However, our knowledge about its contribution to neurological functions and behavior is incomplete. Here, we investigated whether genetic deficiency or pharmacological activation of KCa3.1 change behavior and cerebral monoamine levels in mice.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind7
Udgave nummer10
Sider (fra-til)e47744
ISSN1932-6203
DOI
StatusUdgivet - 2012

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