TY - JOUR
T1 - Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels
AU - Lambertsen, Kate Lykke
AU - Gramsbergen, Jan Bert
AU - Sivasaravanaparan, Mithula
AU - Ditzel, Nicholas
AU - Møller, Linda Maria Sevelsted
AU - Oliván-Viguera, Aida
AU - Rabjerg, Maj
AU - Wulff, Heike
AU - Köhler, Ralf
PY - 2012
Y1 - 2012
N2 - The calmodulin/calcium-activated K(+) channel KCa3.1 is expressed in red and white blood cells, epithelia and endothelia, and possibly central and peripheral neurons. However, our knowledge about its contribution to neurological functions and behavior is incomplete. Here, we investigated whether genetic deficiency or pharmacological activation of KCa3.1 change behavior and cerebral monoamine levels in mice.
AB - The calmodulin/calcium-activated K(+) channel KCa3.1 is expressed in red and white blood cells, epithelia and endothelia, and possibly central and peripheral neurons. However, our knowledge about its contribution to neurological functions and behavior is incomplete. Here, we investigated whether genetic deficiency or pharmacological activation of KCa3.1 change behavior and cerebral monoamine levels in mice.
U2 - 10.1371/journal.pone.0047744
DO - 10.1371/journal.pone.0047744
M3 - Journal article
C2 - 23077667
SN - 1932-6203
VL - 7
SP - e47744
JO - PLOS ONE
JF - PLOS ONE
IS - 10
ER -