Genetic Factors Explain Variation in the Age at Onset of Psoriasis: A Population-based Twin Study

Ann Sophie Lønnberg, Lone Skov, David Lorenzo Duffy, Axel Skytthe, Kirsten Ohm Kyvik, Ole Birger Pedersen, Simon Francis Thomsen

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Resumé

The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error = 0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p = 0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset = 1.01 (0.99-1.03), p = 0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.
OriginalsprogEngelsk
Tidsskrift Acta Dermato-Venereologica
Vol/bind96
Udgave nummer1
Sider (fra-til)35-38
ISSN0001-5555
DOI
StatusUdgivet - jan. 2016

Fingeraftryk

Twin Studies
Age of Onset
Psoriasis
Population
Dizygotic Twins
Monozygotic Twins
Survival Analysis
Registries
Regression Analysis

Citer dette

Lønnberg, Ann Sophie ; Skov, Lone ; Duffy, David Lorenzo ; Skytthe, Axel ; Kyvik, Kirsten Ohm ; Pedersen, Ole Birger ; Thomsen, Simon Francis. / Genetic Factors Explain Variation in the Age at Onset of Psoriasis : A Population-based Twin Study. I: Acta Dermato-Venereologica. 2016 ; Bind 96, Nr. 1. s. 35-38.
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abstract = "The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error = 0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p = 0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset = 1.01 (0.99-1.03), p = 0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.",
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Genetic Factors Explain Variation in the Age at Onset of Psoriasis : A Population-based Twin Study. / Lønnberg, Ann Sophie; Skov, Lone; Duffy, David Lorenzo; Skytthe, Axel; Kyvik, Kirsten Ohm; Pedersen, Ole Birger; Thomsen, Simon Francis.

I: Acta Dermato-Venereologica, Bind 96, Nr. 1, 01.2016, s. 35-38.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Genetic Factors Explain Variation in the Age at Onset of Psoriasis

T2 - A Population-based Twin Study

AU - Lønnberg, Ann Sophie

AU - Skov, Lone

AU - Duffy, David Lorenzo

AU - Skytthe, Axel

AU - Kyvik, Kirsten Ohm

AU - Pedersen, Ole Birger

AU - Thomsen, Simon Francis

PY - 2016/1

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N2 - The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error = 0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p = 0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset = 1.01 (0.99-1.03), p = 0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

AB - The aim of this study was to determine the age at onset of psoriasis in a population-based twin sample. Questionnaire-data in 10,725 twin pairs, 20-71 years of age, from the Danish Twin Registry, was collected, and analysed using survival regression analysis. Median age at onset was 25 and 28 years among women and men, respectively. The correlation between the ages was 0.84 (bootstrap standard error = 0.044) in monozygotic twin pairs and 0.60 (0.051) in dizygotic twin pairs, permutation p = 0.001. Age at onset of psoriasis in the index twin did not predict risk of psoriasis in the co-twin, hazard ratio (per year of later onset = 1.01 (0.99-1.03), p = 0.434. In conclusion, these data support that the age at onset of psoriasis is, in part, an inherited property. Our results do not support that early-onset psoriasis is more genetically determined.

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JO - Acta Dermatovenereologica

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