Genetic and environmental influences in Dupuytren's disease: A study of 30,330 Danish twin pairs

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

We aimed to assess the relative contribution of genes and environment in the aetiology of Dupuytren's disease by studying Danish twins born between 1870 and 2000. Twins with a diagnosis (n = 365) and the subgroup who also had an operation (n = 259) after 1977 were identified through linkage with a nationwide hospital registry among 30,330 monozygotic and same-sexed dizygotic twin pairs. Since monozygotic twins share all their genes and dizygotic twins share on average half of their genetic material, greater phenotypic similarity is expected in monozygotic than in dizygotic twins if a genetic component is involved. The number of concordant male twin pairs with Dupuytren's disease was 17 and 7 (monozygotic and dizygotic pairs, respectively), compared with 60 and 174 discordant monozygotic and dizygotic pairs, yielding probandwise concordance rates of 0.37 (95% confidence interval (CI): 0.26 to 0.50) and 0.07 (95% CI: 0.04 to 0.14), respectively. The heritability of Dupuytren's disease was approximately 80%. We conclude that genetic factors play a major role in the development of Dupuytren's disease.

OriginalsprogEngelsk
TidsskriftJournal of Hand Surgery (European Volume)
Vol/bind40
Udgave nummer2
Sider (fra-til)171-176
ISSN1753-1934
DOI
StatusUdgivet - feb. 2015

Fingeraftryk

Dupuytren Contracture
Dizygotic Twins
Confidence Intervals
Monozygotic Twins
Registries

Emneord

  • Dupuytren's disease
  • Genetic
  • Hereditary
  • Twin study

Citer dette

@article{3674b656b35c4bc0bdd044dff9ef6252,
title = "Genetic and environmental influences in Dupuytren's disease: A study of 30,330 Danish twin pairs",
abstract = "We aimed to assess the relative contribution of genes and environment in the aetiology of Dupuytren's disease by studying Danish twins born between 1870 and 2000. Twins with a diagnosis (n = 365) and the subgroup who also had an operation (n = 259) after 1977 were identified through linkage with a nationwide hospital registry among 30,330 monozygotic and same-sexed dizygotic twin pairs. Since monozygotic twins share all their genes and dizygotic twins share on average half of their genetic material, greater phenotypic similarity is expected in monozygotic than in dizygotic twins if a genetic component is involved. The number of concordant male twin pairs with Dupuytren's disease was 17 and 7 (monozygotic and dizygotic pairs, respectively), compared with 60 and 174 discordant monozygotic and dizygotic pairs, yielding probandwise concordance rates of 0.37 (95{\%} confidence interval (CI): 0.26 to 0.50) and 0.07 (95{\%} CI: 0.04 to 0.14), respectively. The heritability of Dupuytren's disease was approximately 80{\%}. We conclude that genetic factors play a major role in the development of Dupuytren's disease.",
keywords = "Dupuytren's disease, Genetic, Hereditary, Twin study, Dupuytren's disease, genetic, hereditary, twin study",
author = "S{\o}ren Larsen and Krogsgaard, {D G} and Larsen, {Lisbeth Aagaard} and M Iachina and A Skytthe and Henrik Frederiksen",
note = "{\circledC} The Author(s) 2014.",
year = "2015",
month = "2",
doi = "10.1177/1753193414535720",
language = "English",
volume = "40",
pages = "171--176",
journal = "Journal of Hand Surgery (European Volume)",
issn = "1753-1934",
publisher = "SAGE Publications",
number = "2",

}

Genetic and environmental influences in Dupuytren's disease : A study of 30,330 Danish twin pairs. / Larsen, Søren; Krogsgaard, D G; Larsen, Lisbeth Aagaard; Iachina, M; Skytthe, A; Frederiksen, Henrik.

I: Journal of Hand Surgery (European Volume), Bind 40, Nr. 2, 02.2015, s. 171-176.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Genetic and environmental influences in Dupuytren's disease

T2 - A study of 30,330 Danish twin pairs

AU - Larsen, Søren

AU - Krogsgaard, D G

AU - Larsen, Lisbeth Aagaard

AU - Iachina, M

AU - Skytthe, A

AU - Frederiksen, Henrik

N1 - © The Author(s) 2014.

PY - 2015/2

Y1 - 2015/2

N2 - We aimed to assess the relative contribution of genes and environment in the aetiology of Dupuytren's disease by studying Danish twins born between 1870 and 2000. Twins with a diagnosis (n = 365) and the subgroup who also had an operation (n = 259) after 1977 were identified through linkage with a nationwide hospital registry among 30,330 monozygotic and same-sexed dizygotic twin pairs. Since monozygotic twins share all their genes and dizygotic twins share on average half of their genetic material, greater phenotypic similarity is expected in monozygotic than in dizygotic twins if a genetic component is involved. The number of concordant male twin pairs with Dupuytren's disease was 17 and 7 (monozygotic and dizygotic pairs, respectively), compared with 60 and 174 discordant monozygotic and dizygotic pairs, yielding probandwise concordance rates of 0.37 (95% confidence interval (CI): 0.26 to 0.50) and 0.07 (95% CI: 0.04 to 0.14), respectively. The heritability of Dupuytren's disease was approximately 80%. We conclude that genetic factors play a major role in the development of Dupuytren's disease.

AB - We aimed to assess the relative contribution of genes and environment in the aetiology of Dupuytren's disease by studying Danish twins born between 1870 and 2000. Twins with a diagnosis (n = 365) and the subgroup who also had an operation (n = 259) after 1977 were identified through linkage with a nationwide hospital registry among 30,330 monozygotic and same-sexed dizygotic twin pairs. Since monozygotic twins share all their genes and dizygotic twins share on average half of their genetic material, greater phenotypic similarity is expected in monozygotic than in dizygotic twins if a genetic component is involved. The number of concordant male twin pairs with Dupuytren's disease was 17 and 7 (monozygotic and dizygotic pairs, respectively), compared with 60 and 174 discordant monozygotic and dizygotic pairs, yielding probandwise concordance rates of 0.37 (95% confidence interval (CI): 0.26 to 0.50) and 0.07 (95% CI: 0.04 to 0.14), respectively. The heritability of Dupuytren's disease was approximately 80%. We conclude that genetic factors play a major role in the development of Dupuytren's disease.

KW - Dupuytren's disease

KW - Genetic

KW - Hereditary

KW - Twin study

KW - Dupuytren's disease

KW - genetic

KW - hereditary

KW - twin study

U2 - 10.1177/1753193414535720

DO - 10.1177/1753193414535720

M3 - Journal article

C2 - 24835475

VL - 40

SP - 171

EP - 176

JO - Journal of Hand Surgery (European Volume)

JF - Journal of Hand Surgery (European Volume)

SN - 1753-1934

IS - 2

ER -