Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A

Morad Kamand*, Mirolyuba Ilieva, Sheena Louise Forsberg, Mads Thomassen, Åsa Fex Svenningsen, Morten Meyer, Tanja Maria Michel

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Abstrakt

Autism is a heterogeneous neurodevelopmental disorder defined by deficits in socialization, communication, and patterns of behavior. Using stem cells to model brain disorders may yield new understanding about the underlying neuropathological processes and could prove essential for drug development. We present here a new human induced pluripotent stem cell (iPSC) line (SDUKIi004-A) generated from skin fibroblasts derived from a 21-year old male patient diagnosed with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) (“FYNEN-cohort”). Reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities.

OriginalsprogEngelsk
Artikelnummer102038
TidsskriftStem Cell Research
Vol/bind49
Antal sider5
ISSN1873-5061
DOI
StatusUdgivet - dec. 2020

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